FIGURE

Fig. 3

ID

ZDB-FIG-150309-17

Publication

Gabor et al., 2014 - Influenza a virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

IAV infection causes a disease phenotype in zebrafish. Brightfield microscopy of live zebrafish at 24, 48 and 72 hpi, side oriented, anterior left, dorsal top, magnification ×25. The data presented represent three individual experiments, a mean of n=7 fish per treatment. (A,C,E) PBS-injected controls. Development proceeded normally in PBS-injected controls at 24 hpi (A), 48 hpi (C) and 72 hpi (E). (B,D,F) APR8-infected zebrafish. Embryos infected with APR8 or X-31 (data not shown) displayed symptoms of infection. IAV-infected zebrafish had pericardial edema (black arrowheads in B,D,F) and yolk sac edema (white arrowheads in B,D,F). IAV-infected zebrafish also had craniofacial abnormalities (red arrowhead in D) and arched backs (red arrowhead in F). The most striking phenotype of IAV-infected zebrafish was generalized edema that worsened over time.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	viral treatment: unidentified influenza virus
Observed In:	cranium pericardium trunk yolk
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.