FIGURE

Fig. 6

ID

ZDB-FIG-140811-42

Publication

Zhu et al., 2014 - Haploinsufficiency of Def Activates p53-Dependent TGFbeta Signalling and Causes Scar Formation after Partial Hepatectomy

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Fig. 6

Constitutive activation of TGFβ signalling promotes ColI deposition at the amputation site in def^+/- fish after PH.

(A–D) Representative images of immunostaining of pSmad2 (red) and Bhmt (green) in wound epidermis in wild-type (A), def^+/- (B), def^+/- treated with SB431542 (C) or def^+/-treated with Dex (D) 1.5, 3 and 5 days after PH, respectively. (E,F) Representative images of immunostaining of ColI (red) and Bhmt (green) in the wound epidermis in wild-type and def^+/-fish treated or not treated with SB431542 (E) or Dex (F) 5 days after PH, respectively. Nuclei were stained with DAPI (blue). In each case, more than 10 sections from at least three wild-type or def^+/- mutant fish were examined. bc, blood clot; lv, liver tissue; we, wound epidermis. Scale bar:75 μm (A–F).

Expression Data

Antibodies:	Ab-smad2 Ab1-bhmt Ab2-col1a1
Fish:	WT utp25^hi429Tg/+
Condition:	physical alteration: anatomical structure
Anatomical Terms:	hepatocyte liver regenerating tissue
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	utp25^hi429Tg/+
Condition:	physical alteration: anatomical structure
Observed In:	liver connective tissue replacement involved in inflammatory response wound healing
Stage:	Adult

Phenotype Detail

Acknowledgments

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