ZFIN ID: ZDB-FIG-140714-44
Stawicki et al., 2014 - The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function. Disease models & mechanisms   7:847-856 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Antibody:
Fish:
Condition:
Anatomical Term:
Stage: Day 5
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 2

merovingian mutants are resistant to toxicant-induced hair cell death. (A) Quantification of lateral line hair cell number in wild-type siblings and merovingian mutants; ***P<0.0001 by Student’s t-test (n=10 fish). (B) Hair cells labeled with parvalbumin in merovingian mutants and wild-type siblings without (left) and with (right) neomycin treatment. merovingian mutants show reduced initial hair cell numbers, but no hair cell loss in response to neomycin. (C) merovingian mutants show a significant resistance to neomycin-induced hair cell death; P<0.0001 by two-way ANOVA (n=10 fish). (D) merovingian mutants are partially resistant to cisplatin-induced hair cell death. Genotypes are significantly different; P<0.0001 by two-way ANOVA (n=6–10 fish). Error bars indicate s.d. Scale bar: 10 μm.

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-pvalb IHC WT chemical treatment: pharmaceutical Day 5 neuromast hair cell
IHC gcm2w40/w40(AB) standard conditions Day 5 neuromast hair cell
IHC gcm2w40/w40(AB) chemical treatment: pharmaceutical Day 5 neuromast hair cell
Phenotype Details
Fish Conditions Stage Phenotype
gcm2w40/w40(AB) standard conditions Day 5 neuromast hair cell decreased amount, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Disease models & mechanisms for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dis. Model. Mech.