FIGURE

Fig. S7

ID

ZDB-FIG-140612-14

Publication

Nesin et al., 2014 - Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

Other Figures

All Figure Page

Back to All Figure Page

Fig. S7

Overexpression of STIM1_R304W causes hypoplastic caudal vein formation in developing zebrafish embryos. (A–D) Lateral views of a control (A) or STIM1_R304W (C)-injected Tg(Fli1:GFP) transgenic embryo expressing GFP in endothelial cells and hence allowing the visualization of developing blood vessels 48 hpf. B and D are magnified views of the boxed area in A in the respective embryos, showing that the caudal vein in the STIM1_R304W injected embryos (C) appears hypoplastic compared with the controls (B). (E) Percent distribution of normal vs. abnormal embryos as determined by phenotypic aberrations of the caudal vein (**P < 0.001, ***P < 0.0001).

Expression Data

Gene:	EGFP
Fish:	y1Tg
Anatomical Terms:	endothelial cell vasculature
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA