FIGURE

Fig. 2

ID

ZDB-FIG-131004-13

Publication

Mao et al., 2013 - Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes

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Fig. 2

Wild type zebrafish at 4 day post fertilization (dpf).Arrow indicating the glomeruli with visible GFP. B) Phenotype of Myo1e morphants at 4 dpf (days post fertilization) with Myo1e specific knock-down morpholino injected.

Note the pericardial edema (arrow) and invisible GFP indicating the destruction of glomerular structure. C) Proteinuria (arrow indicating Vitellogenin at 70kD band) in concentrated incubation medium of zebrafish larvae after MYO1E knock-down. BSA: bovine serum albumin. D) Histological sections at the level of the glomerulus in zebrafish injected Myo1e MO. The expanded Bowman’s space and destroyed glomeruli observed in MYO1E knock-down zebrafish compared with wild type zebrafish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-myo1ea + MO1-myo1eb
Knockdown Reagents:	MO1-myo1ea MO1-myo1eb
Observed In:	glomerular filtration pericardium pronephric capsular space pronephros
Stage:	Day 4

Phenotype Detail

Acknowledgments

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