FIGURE

Fig. 2

ID
ZDB-FIG-130814-13
Publication
Catterson et al., 2013 - Fermitins, the Orthologs of Mammalian Kindlins, Regulate the Development of a Functional Cardiac Syncytium in Drosophila melanogaster
Other Figures
All Figure Page
Back to All Figure Page
Fig. 2

Fermitins regulate coupling between cardiomyocytes.

The monochrome micrographs show the adult Drosophila heart (segments A2 to A5) stained with phalloidin, oriented with the anterior region to the left. Genes were silenced using the Hand-Gal4 enhancer which drives expression in cardiomyocytes (as well as pericardial nephrocytes and enterocytes of the gut) and abnormal cardiomyocyte/heart morphology is highlighted by the arrows. The colour panels show higher magnification micrographs of at least two cardiomyocytes stained with phalloidin (red) and antibodies to the Drosophila β-integrin, myospheroid (green); arrowheads indicate normal integrin staining between cardiomyocytes; asterisks indicate an abnormal staining pattern associated with loss of cardiomyocyte junction integrity. A wild type phenotype (Hand-Gal4; w1118), is characterised by contiguous cardiomyocytes and β-integrin staining between cardiomyocytes.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One