Fig. 5
- ID
- ZDB-FIG-120717-21
- Publication
- Gaudin et al., 2012 - Chemoattractant axon guidance cues regulate de novo axon trajectories in the embryonic forebrain of zebrafish
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EDAB is distinct from the stria medullaris. All images are confocal projections of zebrafish whole-mounted brains immunolabelled for expression of acetylated α-tubulin. (A), (B), (D) Lateral view (anterior is left, dorsal is up). (C) Dorsal view (anterior is left). (A) At 36 hpf, two new axon tracts extend into the diencephalon: the tract of the habenular commissure (large arrow) and the pioneer axons of the stria medullaris (chevron arrow). (B) At 48 hpf, the stria medullaris (chevron arrow) and the tract of the habenular commissure (large arrow) have both enlarged considerably and have fused together to project to the habenula in the dorsal diencephalon. (C) Dorsal view of a 48 hpf dcc+ntn1a MO injected brain exhibiting the typical ectopic diencephalic axon tract in the dorsal diencephalon (thin arrow). Note that the left-side ectopic tract crosses the midline (arrowhead) before merging with its contralateral counterpart. The ectopic tract that remained ipsilateral merged with the THC (large arrow). Chevron arrows indicate the stria medullaris on both sides. (D) Lateral view of a 48 hpf dcc+ntn1a MO injected brain. Note the dorsal ectopic tract (thin arrow) that is distinct from the stria medullaris (chevron arrow) and fusing into the THC (large arrow). Scale bars=40 μm (A, B, D), 30 μm (C). |
Reprinted from Developmental Biology, 367(2), Gaudin, A., Hofmeister, W., and Key, B., Chemoattractant axon guidance cues regulate de novo axon trajectories in the embryonic forebrain of zebrafish, 126-139, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.