FIGURE

Fig. 3

ID

ZDB-FIG-070418-20

Publication

Voas et al., 2007 - alphaII-Spectrin Is Essential for Assembly of the Nodes of Ranvier in Myelinated Axons

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

Localization of αII-Spectrin in Myelinated Axons (A–B) Adult optic nerve (A) and PLLn (B) labeled with anti-αII-spectrin. Nodes are labeled with anti-FIGQY [6]. The anti-αII-spectrin labeling alone is shown in (A22) and (B22). Expression of αII-spectrin is enriched in the paranodes (indicated by arrowheads). (C–G) Nodes from the PLLn of 2.5–9 dpf embryos and larvae labeled with anti-FIGQY and anti-αII-spectrin. The anti-αII-spectrin labeling alone is shown in (C22)–(G22). At these stages, αII-spectrin is enriched in various combinations of nodes and paranodes. Arrowheads indicate αII-spectrin enrichment in paranodes (PN). (H) No αII-spectrin labeling was detected in αII-spn^st60 mutants. (I) A histogram indicating percentages of PLLn nodes with different αII-spectrin localization patterns at 2.5 dpf (101 nodes from 6 embryos), 3 dpf (102 nodes from 16 embryos), 5 dpf (101 nodes from 13 larvae), 7 dpf (104 nodes from 17 larvae), 9 dpf (106 nodes from 18 larvae), and adult stage (94 nodes from 3 adults). A node or paranode was considered enriched if its anti-αII-spectrin labeling was appreciably greater than the neighboring internodes. All scale bars represent 2 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Curr. Biol.