- Title
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Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways
- Authors
- Zhang, C., Li, C., Chen, S., Li, Z., Jia, X., Wang, K., Bao, J., Liang, Y., Wang, X., Chen, M., Li, P., Su, H., Wan, J.B., Lee, S.M., Liu, K., He, C.
- Source
- Full text @ Redox Biol.
The effect of BBR on 6-OHDA-induced dopaminergic (DA) neuron loss in zebrafish. Zebrafish embryos at 1 day post fertilization were exposed to different concentrations of BBR or nomifensine (Nom, used as a positive control), and then treated with or without 250 µM 6-OHDA for 48 h. Then zebrafish larvae were fixed for whole-mount immunostaining. (A) Representative morphology of DA neurons in the zebrafish brain indicated by immunostaining with antibody against tyrosine hydroxylase (TH). (B) Statistical analysis of TH+ neuron in each group, 10 fish/group were used. Values represent the mean ± SD (n = 3). Data is expressed as a percentage of the control group. ###P < 0.01 versus control (CTL) group, **P < 0.01 versus vehicle (Veh) + 6-OHDA-treated group. PHENOTYPE:
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ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. PHENOTYPE:
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