FIGURE

Fig. 5

ID

ZDB-FIG-170421-13

Publication

Zhang et al., 2017 - Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

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Fig. 5

The effect of BBR on 6-OHDA-induced dopaminergic (DA) neuron loss in zebrafish. Zebrafish embryos at 1 day post fertilization were exposed to different concentrations of BBR or nomifensine (Nom, used as a positive control), and then treated with or without 250 µM 6-OHDA for 48 h. Then zebrafish larvae were fixed for whole-mount immunostaining. (A) Representative morphology of DA neurons in the zebrafish brain indicated by immunostaining with antibody against tyrosine hydroxylase (TH). (B) Statistical analysis of TH⁺ neuron in each group, 10 fish/group were used. Values represent the mean ± SD (n = 3). Data is expressed as a percentage of the control group. ^###P < 0.01 versus control (CTL) group, **P < 0.01 versus vehicle (Veh) + 6-OHDA-treated group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment: oxidopamine chemical treatment: berberine chemical treatment: nomifensine
Observed In:	dopaminergic neuron
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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