Gene
eef1a1l1
- ID
- ZDB-GENE-990415-52
- Name
- eukaryotic translation elongation factor 1 alpha 1, like 1
- Symbol
- eef1a1l1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in cytoplasm. Is expressed in several structures, including integument; musculature system; nervous system; pleuroperitoneal region; and skeletal system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 63 figures from 46 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910540 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR031157 | Tr-type G domain, conserved site |
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Domain | IPR054696 | GTP-eEF1A, C-terminal domain |
| Family | IPR004539 | Translation elongation factor EF1A, eukaryotic/archaeal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | GTP-eEF1A, C-terminal domain | P-loop containing nucleoside triphosphate hydrolase | Translational (tr)-type GTP-binding domain | Translation elongation factor EF1A, eukaryotic/archaeal | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal | Translation elongation factor EFTu-like, domain 2 | Translation factor GTPase superfamily members | Translation protein, beta-barrel domain superfamily | Tr-type G domain, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q92005 | InterPro | 462 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eef1a1l1-201
(1)
|
Ensembl | 1,745 nt | ||
| mRNA |
eef1a1l1-202
(1)
|
Ensembl | 4,216 nt | ||
| mRNA |
eef1a1l1-203
(1)
|
Ensembl | 4,455 nt | ||
| mRNA |
eef1a1l1-204
(1)
|
Ensembl | 4,455 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-eef1a1l1 | polyclonal | IgG | Rabbit |
|
GeneTex
|
3 |
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Plasmids
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Sultmann, et al, 2000. (ZDB-PUB-001220-4) report orthology of this gene to human EF1A (now EEF1A1) based on amino acid similarity and conserved location. Subsequent analysis suggests eef1a1a (ZDB-GENE-030131-8278) and eef1a1b (ZDB-GENE-050417-327) are the orthologous genome duplicates of human EEF1A1 and mouse Eef1a1 based on amino acid similarity and conserved location.
- Ai, N., Han, C.R., Zhao, H., Cheng, S.Y., Ge, W. (2024) Disruption of thyroid hormone receptor thrab leads to female infertility in zebrafish. Endocrinology. 165(5):
- Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., Witten, P.E. (2024) Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR plus. 8:ziae081ziae081
- Li, G., Sun, Y., Kwok, I., Yang, L., Wen, W., Huang, P., Wu, M., Li, J., Huang, Z., Liu, Z., He, S., Peng, W., Bei, J.X., Ginhoux, F., Ng, L.G., Zhang, Y. (2024) Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish. Nature communications. 15:811811
- Ou, Y., Li, H., Li, J., Dai, X., He, J., Wang, S., Liu, Q., Yang, C., Wang, J., Zhao, R., Yin, Z., Shu, Y., Liu, S. (2024) Formation of different polyploids through disrupting meiotic crossover frequencies based on cntd1 knockout in zebrafish. Molecular Biology and Evolution. 41(3):
- Wijerathna, H.M.S.M., Shanaka, K.A.S.N., Raguvaran, S.S., Jayamali, B.P.M.V., Kim, S.H., Kim, M.J., Jung, S., Lee, J. (2024) CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening. International Journal of Molecular Sciences. 25(19):
- Xia, Z., Tang, B., Li, X., Li, X., Jia, Y., Jiang, J., Chen, J., Song, J., Liu, S., Min, J., Wang, F. (2024) A Novel Role for the Longevity-Associated Protein SLC39A11 as a Manganese Transporter. Research (Washington, D.C.). 7:04400440
- Zanardini, M., Zhang, W., Habibi, H.R. (2024) Arginine Vasotocin Directly Regulates Spermatogenesis in Adult Zebrafish (Danio rerio) Testes. International Journal of Molecular Sciences. 25(12):
- Zhao, S., Mo, G., Wang, Q., Xu, J., Yu, S., Huang, Z., Liu, W., Zhang, W. (2024) Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. 10:182182
- Zhou, C., Li, M., Sun, Y., Sultan, Y., Li, X. (2024) Systematic Identification of Long Noncoding RNAs during Three Key Organogenesis Stages in Zebrafish. International Journal of Molecular Sciences. 25(6):
- Chiang, D.Y., Verkerk, A.O., Victorio, R., Shneyer, B.I., van der Vaart, B., Jouni, M., Narendran, N., Kc, A., Sampognaro, J.R., Vetrano-Olsen, F., Oh, J.S., Buys, E., de Jonge, B., Shah, D.A., Kiviniemi, T., Burridge, P.W., Bezzina, C.R., Akhmanova, A., MacRae, C.A. (2023) The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Circulation research. 134(1):46-59
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