ZFIN

ZFIN ID: ZDB-GENE-081104-306

ZFIN ID: ZDB-GENE-081104-306

CITATIONS (52 total)

Gene Name:	cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
Gene Symbol:	cdkn2a/b

Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654

El Maï, M., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J.M., Kang, D., Pourcher, T., Yue, J.X., Ferreira, M.G. (2023) Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nature aging. 3(5):567-584

Morgan, K.J., Doggett, K., Geng, F., Mieruszynski, S., Whitehead, L., Smith, K.A., Hogan, B.M., Simons, C., Baillie, G.J., Molania, R., Papenfuss, A.T., Hall, T.E., Ober, E.A., Stainier, D.Y.R., Gong, Z., Heath, J.K. (2023) ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. eLIFE. 12:

Morsli, S., Henriques, C.M., Ellis, P.S., Mortiboys, H., Baxendale, S., Loynes, C.A., Renshaw, S.A., Bellantuono, I. (2023) A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo. Aging Cell. 22(6):e13835

Zapilko, V., Moisio, S., Parikka, M., Heinäniemi, M., Lohi, O. (2023) Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia. Cancers. 15(24):

Zhang, Y., Peng, X., Xue, M., Liu, J., Shang, G., Jiang, M., Chen, D., Liu, B., Wang, Y., Jia, X., Xu, J., Zhang, F., Hu, Y. (2023) SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway. Biogerontology. 24(5):813-827

Haraoka, Y., Akieda, Y., Nagai, Y., Mogi, C., Ishitani, T. (2022) Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Nature communications. 13:1417

Tian, Y., Wang, W., Lautrup, S., Zhao, H., Li, X., Law, P.W.N., Dinh, N.D., Fang, E.F., Cheung, H.H., Chan, W.Y. (2022) WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nature communications. 13:5456

Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):

Cui, X., Du, C., Wan, S., Wu, D., Yan, L., Zhang, J., Li, J., Li, H., Yang, Z., Zhang, H., Zhang, J., Mu, H., Zhang, F., Peng, X., Liu, M., Hu, Y. (2021) Deficiency of Heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21^cip1 expression. Biochimica et biophysica acta. Molecular basis of disease. 1867(11):166233

Gulluni, F., Prever, L., Li, H., Krafcikova, P., Corrado, I., Lo, W.T., Margaria, J.P., Chen, A., De Santis, M.C., Cnudde, S.J., Fogerty, J., Yuan, A., Massarotti, A., Sarijalo, N.T., Vadas, O., Williams, R.L., Thelen, M., Powell, D.R., Schueler, M., Wiesener, M.S., Balla, T., Baris, H.N., Tiosano, D., McDermott, B.M., Perkins, B.D., Ghigo, A., Martini, M., Haucke, V., Boura, E., Merlo, G.R., Buchner, D.A., Hirsch, E. (2021) PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Science (New York, N.Y.). 374:eabk0410

Paramos-de-Carvalho, D., Martins, I., Cristóvão, A.M., Dias, A.F., Neves-Silva, D., Pereira, T., Chapela, D., Farinho, A., Jacinto, A., Saúde, L. (2021) Targeting senescent cells improves functional recovery after spinal cord injury. Cell Reports. 36:109334

Da Silva-Álvarez, S., Guerra-Varela, J., Sobrido-Cameán, D., Quelle, A., Barreiro-Iglesias, A., Sánchez, L., Collado, M. (2020) Developmentally-programmed cellular senescence is conserved and widespread in zebrafish. Aging. 12(18):17895-17901

El Maï, M., Marzullo, M., de Castro, I.P., Ferreira, M.G. (2020) Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. eLIFE. 9:

Lex, K., Maia Gil, M., Lopes-Bastos, B., Figueira, M., Marzullo, M., Giannetti, K., Carvalho, T., Ferreira, M.G. (2020) Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 117(26):15066-15074

Oyarbide, U., Shah, A.N., Amaya-Mejia, W., Snyderman, M., Kell, M., Allende, D., Calo, E., Topczewski, J., Corey, S. (2020) Loss of Sbds in zebrafish leads to neutropenia and pancreas and liver atrophy. JCI insight. 5(17)

Pandelides, Z., Thornton, C., Faruque, A.S., Whitehead, A.P., Willett, K.L., Ashpole, N.M. (2020) Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio). GeroScience. 42(2):785-800

Pandelides, Z., Thornton, C., Lovitt, K.G., Faruque, A.S., Whitehead, A.P., Willett, K.L., Ashpole, N.M. (2020) Developmental exposure to Δ⁹-tetrahydrocannabinol (THC) causes biphasic effects on longevity, inflammation, and reproduction in aged zebrafish (Danio rerio). GeroScience. 42(3):923-936

Shao, X., Fu, Y., Ma, J., Li, X., Lu, C., Zhang, R. (2020) Functional alterations and transcriptomic changes during zebrafish cardiac aging. Biogerontology. 21(5):637-652

Chen, W.M., Chiang, J.C., Lin, Y.C., Lin, Y.N., Chuang, P.Y., Chang, Y.C., Chen, C.C., Wu, K.Y., Hsieh, J.C., Chen, S.K., Huang, W.P., Chen, B.P.C., Lee, H. (2019) Lysophosphatidic acid receptor LPA₃ prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome. Aging Cell. 19(1):e13064

Jung, I.H., Jung, D.E., Chung, Y.Y., Kim, K.S., Park, S.W. (2019) Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression. Neoplasia (New York, N.Y.). 21:1003-1014

Novoa, B., Pereiro, P., López-Muñoz, A., Varela, M., Forn-Cuní, G., Anchelin, M., Dios, S., Romero, A., Martinez-López, A., Medina-Gali, R.M., Collado, M., Coll, J., Estepa, A., Cayuela, M.L., Mulero, V., Figueras, A. (2019) Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. Aging Cell. 18(5):e13020

Soundararajan, A., Yoganantharajah, P., Raghavan, S., Mohan, V., Balasubramanyam, M., Gibert, Y. (2019) Bisphenol A exposure under metabolic stress induces accelerated cellular senescence in vivo in a p53 independent manner. The Science of the total environment. 689:1201-1211

Sun, X., Zhang, R., Liu, M., Chen, H., Chen, L., Luo, F., Zhang, D., Huang, J., Li, F., Ni, Z., Qi, H., Su, N., Jin, M., Yang, J., Tan, Q., Du, X., Chen, B., Huang, H., Chen, S., Yin, L., Xu, X., Deng, C., Luo, L., Xie, Y., Chen, L. (2019) Rmrp mutation disrupts chondrogenesis and bone ossification in zebrafish model of cartilage-hair hypoplasia via enhanced Wnt/β-catenin signaling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 34(11):2101-2116

Ablain, J., Xu, M., Rothschild, H., Jordan, R.C., Mito, J.K., Daniels, B.H., Bell, C.F., Joseph, N.M., Wu, H., Bastian, B.C., Zon, L.I., Yeh, I. (2018) Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.. Science (New York, N.Y.). 362(6418):1055-1060

Baell, J.B., Leaver, D.J., Hermans, S.J., Kelly, G.L., Brennan, M.S., Downer, N.L., Nguyen, N., Wichmann, J., McRae, H.M., Yang, Y., Cleary, B., Lagiakos, H.R., Mieruszynski, S., Pacini, G., Vanyai, H.K., Bergamasco, M.I., May, R.E., Davey, B.K., Morgan, K.J., Sealey, A.J., Wang, B., Zamudio, N., Wilcox, S., Garnham, A.L., Sheikh, B.N., Aubrey, B.J., Doggett, K., Chung, M.C., de Silva, M., Bentley, J., Pilling, P., Hattarki, M., Dolezal, O., Dennis, M.L., Falk, H., Ren, B., Charman, S.A., White, K.L., Rautela, J., Newbold, A., Hawkins, E.D., Johnstone, R.W., Huntington, N.D., Peat, T.S., Heath, J.K., Strasser, A., Parker, M.W., Smyth, G.K., Street, I.P., Monahan, B.J., Voss, A.K., Thomas, T. (2018) Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. 560(7717):253-257

Chou, Y.T., Chen, L.Y., Tsai, S.L., Tu, H.C., Lu, J.W., Ciou, S.C., Wang, H.D., Yuh, C.H. (2018) Ribose-5-Phosphate Isomerase A Overexpression Promotes Liver Cancer Development in Transgenic Zebrafish via Activation of ERK and β-catenin Pathways. Carcinogenesis. 40(3):461-473

Chou, Y.T., Jiang, J.K., Yang, M.H., Lu, J.W., Lin, H.K., Wang, H.D., Yuh, C.H. (2018) Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating β-catenin via a novel C-terminal domain. PLoS Biology. 16:e2003714

Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549

Meng, Z.Z., Liu, W., Xia, Y., Yin, H.M., Zhang, C.Y., Su, D., Yan, L.F., Gu, A.H., Zhou, Y. (2017) The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Nature communications. 8:14640

Shim, J., Choi, J.H., Park, M.H., Kim, H., Kim, J.H., Kim, S.Y., Hong, D., Kim, S., Lee, J.E., Kim, C.H., Lee, J.S., Bae, Y.K. (2017) Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation. Oncotarget. 8:55280-55297

Springelkamp, H., Iglesias, A.I., Mishra, A., Höhn, R., Wojciechowski, R., Khawaja, A.P., Nag, A., Wang, Y.X., Wang, J.J., Cuellar-Partida, G., Gibson, J., Cooke Bailey, J.N., Vithana, E.N., Gharahkhani, P., Boutin, T., Ramdas, W.D., Zeller, T., Luben, R.N., Yonova-Doing, E., Viswanathan, A.C., Yazar, S., Cree, A.J., Haines, J.L., Koh, J.Y., Souzeau, E., Wilson, J.F., Amin, N., Müller, C., Venturini, C., Kearns, L.S., Hee Kang, J., Tham, Y.C., Zhou, T., van Leeuwen, E.M., Nickels, S., Sanfilippo, P., Liao, J., Linde, H.V., Zhao, W., van Koolwijk, L.M., Zheng, L., Rivadeneira, F., Baskaran, M., van der Lee, S.J., Perera, S., de Jong, P.T., Oostra, B.A., Uitterlinden, A.G., Fan, Q., Hofman, A., Shyong Tai, E., Vingerling, J.R., Sim, X., Wolfs, R.C., Teo, Y.Y., Lemij, H.G., Khor, C.C., Willemsen, R., Lackner, K.J., Aung, T., Jansonius, N.M., Montgomery, G., Wild, P.S., Young, T.L., Burdon, K.P., Hysi, P.G., Pasquale, L.R., Wong, T.Y., Klaver, C.C., Hewitt, A.W., Jonas, J.B., Mitchell, P., Lotery, A.J., Foster, P.J., Vitart, V., Pfeiffer, N., Craig, J.E., Mackey, D.A., Hammond, C.J., Wiggs, J.L., Cheng, C.Y., van Duijn, C.M., MacGregor, S. (2017) New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Human molecular genetics. 26(2):438-453

Ray, M.K., Wiskow, O., King, M.J., Ismail, N., Ergun, A., Wang, Y., Plys, A.J., Davis, C.P., Kathrein, K., Sadreyev, R., Borowsky, M.L., Eggan, K., Zon, L., Galloway, J.L., Kingston, R.E. (2016) CAT7 and cat7l long non-coding RNAs Tune Polycomb Repressive Complex 1 Function During Human and Zebrafish Development. The Journal of biological chemistry. 291(37):19558-72

Hesse, R.G., Kouklis, G.K., Ahituv, N., Pomerantz, J.H. (2015) The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration. eLIFE. 4

Iglesias, A.I., Springelkamp, H., Linde, H.V., Severijnen, L.A., Amin, N., Oostra, B., Kockx, C.E., van den Hout, M.C., van Ijcken, W.F., Hofman, A., Uitterlinden, A.G., Verdijk, R.M., Klaver, C.C., Willemsen, R., and van Duijn, C.M. (2014) Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Human molecular genetics. 23(5):1320-32

Lister, J.A., Capper, A., Zeng, Z., Mathers, M.E., Richardson, J., Paranthaman, K., Jackson, I.J., and Patton, E.E. (2014) A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo. The Journal of investigative dermatology. 134(1):133-40

Balow, S.A., Pierce, L.X., Zentner, G.E., Conrad, P.A., Davis, S., Sabaawy, H.E., McDermott, B.M., and Scacheri, P.C. (2013) Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome. Developmental Biology. 382(1):57-69

Mochida, G.H., Ganesh, V.S., de Michelena, M.I., Dias, H., Atabay, K.D., Kathrein, K.L., Huang, H.T., Hill, R.S., Felie, J.M., Rakiec, D., Gleason, D., Hill, A.D., Malik, A.N., Barry, B.J., Partlow, J.N., Tan, W.H., Glader, L.J., Barkovich, A.J., Dobyns, W.B., Zon, L.I., and Walsh, C.A. (2012) CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nature Genetics. 44(11):1260-1264

Chapouton, P., Skupien, P., Hesl, B., Coolen, M., Moore, J.C., Madelaine, R., Kremmer, E., Faus-Kessler, T., Blader, P., Lawson, N.D., and Bally-Cuif, L. (2010) Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(23):7961-7974

Sabaawy, H.E., Azuma, M., Embree, L.J., Tsai, H.J., Starost, M.F., and Hickstein, D.D. (2006) TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 103(41):15166-15171

Additional Citations (12):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Curation of NCBI Gene Data Via Shared Ensembl IDs (Supplemental NCBI Load). Automated Data Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Curation of NCBI Gene Data Via Shared Vega Gene IDs. Automated Data Submission.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.