PUBLICATION
Functional alterations and transcriptomic changes during zebrafish cardiac aging
- Authors
- Shao, X., Fu, Y., Ma, J., Li, X., Lu, C., Zhang, R.
- ID
- ZDB-PUB-200507-5
- Date
- 2020
- Source
- Biogerontology 21(5): 637-652 (Journal)
- Registered Authors
- Zhang, Ruilin
- Keywords
- Aging-related markers, Cardiac aging, Functional alterations, Transcriptomic changes
- Datasets
- GEO:GSE143346
- MeSH Terms
-
- Aging*
- Animals
- DNA Damage
- Heart/physiology*
- Inflammation
- Mitochondria, Heart
- Models, Animal
- Transcriptome*
- Zebrafish*/genetics
- PubMed
- 32372324 Full text @ Biogerontology
Citation
Shao, X., Fu, Y., Ma, J., Li, X., Lu, C., Zhang, R. (2020) Functional alterations and transcriptomic changes during zebrafish cardiac aging. Biogerontology. 21(5):637-652.
Abstract
Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafish. In this study we first validated the effectiveness of a panel of aging-related markers and revealed their spatial-temporal specificity. Using these markers, we discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function. Furthermore, we showed aging-related expression profile change in zebrafish hearts was similar to that in rat hearts. Overall, our results provide a deeper insight into the cardiac aging process in zebrafish, which will set up foundation for generating novel cardiac aging models suitable for large scale screening of pharmaceutical targets.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping