ZFIN

ZFIN ID: ZDB-GENE-080429-2

CITATIONS (25 total)

Gene Name:	NLR family, CARD domain containing 5
Gene Symbol:	nlrc5

Yan, Y., Tao, K., Xie, H., Zhou, H., Wu, Q., Pu, S., Li, D., Guo, Z., Zhou, Z., Xu, S. (2026) Radix Rehmanniae Preparata polysaccharide promoted zebrafish heart regeneration by activating the IFN-γ/NF-κB signaling axis. Biology Direct. :

Shanaka, K.A.S.N., Madushani, K.P., Kim, M.J., Jung, S., Lee, J. (2025) Nlrc5 ablation interferes with MHC-I gene expression and immune cell migration. Developmental and comparative immunology. :105406105406

Xia, J., Shen, L., Liu, Y., Wang, L., Liu, F. (2025) Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis. Proceedings of the National Academy of Sciences of the United States of America. 122:e2515641122e2515641122

Chang, M.X., Xiong, F., Wu, X.M., Hu, Y.W. (2020) The expanding and function of NLRC3 or NLRC3-like in teleost fish: recent advances and novel insights. Developmental and comparative immunology. 114:103859

Zhang, Z., Ran, C., Ding, Q.W., Liu, H.L., Xie, M.X., Yang, Y.L., Xie, Y.D., Gao, C.C., Zhang, H.L., Zhou, Z.G. (2019) Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish. Communications biology. 2:274

Cao, L., Wu, X.M., Hu, Y.W., Xue, N.N., Nie, P., Chang, M.X. (2018) The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses. Developmental and comparative immunology. 84:153-163

Wu, X.M., Chen, W.Q., Hu, Y.W., Cao, L., Nie, P., Chang, M.X. (2018) RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Frontiers in immunology. 9:726

Wu, X.M., Hu, Y.W., Xue, N.N., Ren, S.S., Chen, S.N., Nie, P., Chang, M.X. (2017) Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Developmental and comparative immunology. 68:58-68

Howe, K., Schiffer, P.H., Zielinski, J., Wiehe, T., Laird, G.K., Marioni, J.C., Soylemez, O., Kondrashov, F., Leptin, M. (2016) Structure and evolutionary history of a large family of NLR proteins in the zebrafish. Open Biology. 6(4):160009

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

Laing, K.J., Purcell, M.K., Winton, J.R., and Hansen, J.D. (2008) A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish. BMC Evolutionary Biology. 8:42

Additional Citations (13):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2015) Nomenclature Data Curation (2015). Nomenclature Committee Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Curation of NCBI Gene Data Via Shared Vega Gene IDs. Automated Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.