PUBLICATION
The expanding and function of NLRC3 or NLRC3-like in teleost fish: recent advances and novel insights
- Authors
- Chang, M.X., Xiong, F., Wu, X.M., Hu, Y.W.
- ID
- ZDB-PUB-200909-7
- Date
- 2020
- Source
- Developmental and comparative immunology 114: 103859 (Review)
- Registered Authors
- Keywords
- Innate immunity, NLR, NLRC3 expansion, Teleost fish, inflammation
- MeSH Terms
-
- Animals
- Fish Proteins/genetics
- Fish Proteins/metabolism*
- Fishes/immunology
- Fishes/metabolism*
- Immunity, Innate
- Infections/immunology*
- Inflammation/metabolism*
- Intercellular Signaling Peptides and Proteins/genetics
- Intracellular Signaling Peptides and Proteins/genetics
- Intracellular Signaling Peptides and Proteins/metabolism*
- Mammals
- NF-kappa B/metabolism
- Pathogen-Associated Molecular Pattern Molecules/immunology
- Signal Transduction
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 32896535 Full text @ Dev. Comp. Immunol.
Citation
Chang, M.X., Xiong, F., Wu, X.M., Hu, Y.W. (2020) The expanding and function of NLRC3 or NLRC3-like in teleost fish: recent advances and novel insights. Developmental and comparative immunology. 114:103859.
Abstract
The nucleotide-binding domain and leucine-rich repeat-containing family (NLR) proteins are innate immune sensors which recognize highly conserved pathogen-associated molecular patterns (PAMPs). Mammals have small numbers of NLR proteins, whereas in some species such as in invertebrates and jawless vertebrates, NLRs have expanded into very large families. Nearly 400 NLR proteins are identified in the zebrafish genome. Members of the NLR family can be divided into two functional sub-groups based on their ability to either positively or negatively regulate host immune response or inflammatory signaling cascades. Mammalian NLRC3 has been identified as an inhibitory NLR, and serves as a negative regulator in the NF-κB-mediated inflammatory response, STING-mediated DNA sensing and PI3K-mTOR pathways. Different from mammalian NLRC3, the analysis from genomes or transcriptomes revealed that the expansions of NLRC3 existed in different species of fish. Furthermore, piscine NLRC3-like genes were confirmed to have a negative or positive regulatory function in response to different kinds of pathogen infections and in the production of proinflammatory cytokines. In this review, we summarize recent advances in our understanding of the expanding and function of NLRC3 or NLRC3-like genes in teleost fish, and give our view of important directions for future studies. The knowledge of piscine NLRC3 or expansive NLRC3-like genes-mediated biological functions in homeostasis and diseases will shed new light on the prevention and control of inflammatory and/or infectious diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping