Araujo-Silva, H., de Souza, A.M., Mamede, J.P.M., Batistuzzo de Medeiros, S.R., Luchiari, A.C. (2023) Individual differences in response to alcohol and nicotine in zebrafish: gene expression and behavior. Development, growth & differentiation. 65(8):434-445
|
Bampali, K., Koniuszewski, F., Vogel, F.D., Fabjan, J., Andronis, C., Lekka, E., Virvillis, V., Seidel, T., Delaunois, A., Royer, L., Rolf, M.G., Giuliano, C., Traebert, M., Roussignol, G., Fric-Bordat, M., Mazelin-Winum, L., Bryant, S.D., Langer, T., Ernst, M. (2023) GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach. Cell biology and toxicology. 39(6):2793-2819
|
Barnaby, W., Dorman Barclay, H.E., Nagarkar, A., Perkins, M., Teicher, G., Trapani, J.G., Downes, G.B. (2022) GABAA α Subunit Control of Hyperactive Behavior in Developing Zebrafish. Genetics. 220(4):
|
Baxendale, S., Holdsworth, C.J., Santoscoy, P.M., Harrison, M.R., Fox, J., Parkin, C.A., Ingham, P.W., and Cunliffe, V.T. (2012) Identification of compounds with novel anti-convulsant properties in a zebrafish model of epileptic seizures. Disease models & mechanisms. 5(6):773-784
|
Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
|
Bian, Y., Wang, X., Liang, J.H., Li, L., Wu, X., Tang, B., Leung, G.P., Lee, S.M. (2021) The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio). Progress in neuro-psychopharmacology & biological psychiatry. 113:110456
|
|
|
Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. (2020) Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere. 270:128611
|
Chen, H., Chen, K., Qiu, X., Xu, H., Mao, G., Zhao, T., Feng, W., Okeke, E.S., Wu, X., Yang, L. (2020) The reproductive toxicity and potential mechanisms of combined exposure to dibutyl phthalate and diisobutyl phthalate in male zebrafish (Danio rerio). Chemosphere. 258:127238
|
|
|
Chen, Z.W., Peng, C.B., Pei, Z., Zhang, M.R., Yun, T.C., Yang, Z.M., Xu, F.P. (2020) Effects of tenuifolin on rest/wake behaviour in zebrafish. Experimental and Therapeutic Medicine. 19:2326-2334
|
Choo, B.K.M., Kundap, U.P., Faudzi, S.M.M., Abas, F., Shaikh, M.F., Samarut, É. (2021) Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 142:112035
|
Cocco, A., Carolina Rönnberg, A.M., Jin, Z., André, G.I., Vossen, L.E., Bhandage, A.K., Thörnqvist, P.O., Birnir, B., Winberg, S. (2017) Characterisation of the γ-aminobutyric acid signalling system in the zebrafish (Danio rerio Hamilton) central nervous system by reverse transcription quantitative polymerase chain reaction. Neuroscience. 343:300-321
|
Davis, D.J., Doerr, H.M., Grzelak, A.K., Busi, S.B., Jasarevic, E., Ericsson, A.C., Bryda, E.C. (2016) Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish. Scientific Reports. 6:33726
|
|
|
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
|
Gawel, K., Kukula-Koch, W., Banono, N.S., Nieoczym, D., Targowska-Duda, K.M., Czernicka, L., Parada-Turska, J., Esguerra, C.V. (2021) 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish. International Journal of Molecular Sciences. 22(14):
|
Gong, G., Chen, H., Kam, H., Chan, G., Tang, Y.X., Wu, M., Tan, H., Tse, Y.C., Xu, H.X., Lee, S.M. (2020) In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions. Journal of natural products. 83(12):3706-3716
|
|
|
Griffin, A., Carpenter, C., Liu, J., Paterno, R., Grone, B., Hamling, K., Moog, M., Dinday, M.T., Figueroa, F., Anvar, M., Ononuju, C., Qu, T., Baraban, S.C. (2021) Phenotypic analysis of catastrophic childhood epilepsy genes. Communications biology. 4:680
|
|
|
Hotz, A.L., Jamali, A., Rieser, N.N., Niklaus, S., Aydin, E., Myren-Svelstad, S., Lalla, L., Jurisch-Yaksi, N., Yaksi, E., Neuhauss, S.C.F. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia. 70(1):196-214
|
Huang, L., Han, F., Huang, Y., Liu, J., Liao, X., Cao, Z., Li, W. (2023) Sphk1 deficiency induces apoptosis and developmental defects and premature death in zebrafish. Fish physiology and biochemistry. 49(4):737-750
|
Huang, Q.T., Sheng, C.W., Jiang, J., Tang, T., Jia, Z.Q., Han, Z.J., Zhao, C.Q. (2018) Interaction of insecticides with heteromeric GABA-gated chloride channels from zebrafish Danio rerio (Hamilton). Journal of hazardous materials. 366:643-650
|
Ichikawa, S., Abe, R., Fujimoto, H., Higashi, K., Zang, L., Nakayama, H., Matsuoka, I., Shimada, Y. (2023) Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism. Frontiers in microbiology. 14:10791871079187
|
Jiang, Y., Guo, L., He, H., Chen, H., Chen, T., Liu, Y., Zhao, W. (2025) Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Frontiers in bioscience (Landmark edition). 30:3958739587
|
Khezri, A., Fraser, T.W., Nourizadeh-Lillabadi, R., Kamstra, J.H., Berg, V., Zimmer, K.E., Ropstad, E. (2017) A Mixture of Persistent Organic Pollutants and Perfluorooctanesulfonic Acid Induces Similar Behavioural Responses, but Different Gene Expression Profiles in Zebrafish Larvae. International Journal of Molecular Sciences. 18(2)
|
Klee, E.W., Schneider, H., Clark, K.J., Cousin, M.A., Ebbert, J.O., Hooten, W.M., Karpyak, V.M., Warner, D.O., and Ekker, S.C. (2012) Zebrafish: a model for the study of addiction genetics. Human genetics. 131(6):977-1008
|
Li, Y., Zhang, L., Mao, M., He, L., Wang, T., Pan, Y., Zhao, X., Li, Z., Mu, X., Qian, Y., Qiu, J. (2023) Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish. iScience. 26:106744106744
|
Liao, M., Kundap, U., Rosch, R.E., Burrows, D.R.W., Meyer, M.P., Bencheikh, B.O.A., Cossette, P., Samarut, É. (2019) Targeted knockout of GABA receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae. Disease models & mechanisms. 12(11):
|
Locubiche, S., Ordóñez, V., Abad, E., Scotto di Mase, M., Di Donato, V., De Santis, F. (2024) A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0. International Journal of Molecular Sciences. 25(5):
|
Manchanda, A., Bonventre, J.A., Bugel, S.M., Chatterjee, P., Tanguay, R., Johnson, C.P. (2021) Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking. Molecular biology of the cell. 32(14):1293-1305
|
Monesson-Olson, B., McClain, J.J., Case, A.E., Dorman, H.E., Turkewitz, D.R., Steiner, A.B., Downes, G.B. (2018) Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system. PLoS One. 13:e0196083
|
Myren-Svelstad, S., Jamali, A., Ophus, S.S., D'gama, P.P., Ostenrath, A.M., Mutlu, A.K., Hoffshagen, H.H., Hotz, A.L., Neuhauss, S.C.F., Jurisch-Yaksi, N., Yaksi, E. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia. 63:2543-2560
|
Nieoczym, D., Marszalek-Grabska, M., Szalak, R., Kundap, U., Kaczor, A.A., Wrobel, T.M., Kosheva, N., Komar, M., Abram, M., Esguerra, C.V., Samarut, E., Pieróg, M., Jakubiec, M., Kaminski, K., Kukula-Koch, W., Gawel, K. (2024) A comprehensive assessment of palmatine as anticonvulsant agent - In vivo and in silico studies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 172:116234116234
|
Olorocisimo, J.P., Diaz, L.A., Co, D.E., Carag, H.M., Ibana, J.A., Velarde, M.C. (2022) Lactobacillus delbrueckii reduces anxiety-like behavior in zebrafish through a gut microbiome - Brain crosstalk. Neuropharmacology. 225:109401
|
Orellana-Paucar, A.M., Afrikanova, T., Thomas, J., Aibuldinov, Y.K., Dehaen, W., de Witte, P.A., and Esguerra, C.V. (2013) Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. PLoS One. 8(12):e81634
|
Paiva, I.M., Sartori, B.M., Castro, T.F.D., Lunkes, L.C., Virote, B.D.C.R., Murgas, L.D.S., de Souza, R.P., Brunialti-Godard, A.L. (2020) Behavioral plasticity and gene regulation in the brain during an intermittent ethanol exposure in adult zebrafish population. Pharmacology, biochemistry, and behavior. 192:172909
|
|
|
Probst, J., Kölker, S., Okun, J.G., Kumar, A., Gursky, E., Posset, R., Hoffmann, G.F., Peravali, R., Zielonka, M. (2020) Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae. Experimental neurology. 331:113330
|
Pípal, M., Legradi, J., Smutná, M., Kočí, T., Priebojová, J., Bláhová, L., Krauss, M., Hilscherová, K. (2020) Neurobehavioral effects of cyanobacterial biomass field extracts on zebrafish embryos and potential role of retinoids. Aquatic toxicology (Amsterdam, Netherlands). 228:105613
|
|
|
Renier, C., Faraco, J.H., Bourgin, P., Motley, T., Bonaventure, P., Rosa, F., and Mignot, E. (2007) Genomic and functional conservation of sedative-hypnotic targets in the zebrafish. Pharmacogenetics and genomics. 17(4):237-253
|
|
|
Reyes-Nava, N.G., Paz, D., Pinales, B.E., Perez, I., Gil, C.B., Gonzales, A.V., Grajeda, B.I., Estevao, I.L., Ellis, C.C., Castro, V.L., Quintana, A.M. (2024) Characterization of the zebrafish gabra1sa43718/sa43718 germline loss of function allele confirms a function for Gabra1 in motility and nervous system development. Differentiation; research in biological diversity. 138:100790100790
|
Sadamitsu, K., Shigemitsu, L., Suzuki, M., Ito, D., Kashima, M., Hirata, H. (2021) Characterization of zebrafish GABAA receptor subunits. Scientific Reports. 11:6242
|
|
|
Samarut, É., Swaminathan, A., Riché, R., Liao, M., Hassan-Abdi, R., Renault, S., Allard, M., Dufour, L., Cossette, P., Soussi-Yanicostas, N., Drapeau, P. (2018) γ-Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment. Epilepsia. 59(11):2061-2074
|
|
|
Shi, Z., Liang, X., Zhao, Y., Liu, W., Martyniuk, C.J. (2022) Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio). The Science of the total environment. 830:154688
|
Shin, K.C., Hasan, W., Ali, G., Abdelrahman, D., Abuarja, T., Stanton, L.W., Da'as, S.I., Park, Y. (2025) Seizure-like behavior and hyperactivity in napb knockout zebrafish as a model for autism and epilepsy. Scientific Reports. 15:1457914579
|
Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
|
Sugitani, K., Mokuya, T., Homma, S., Maeda, M., Konno, A., Ogai, K. (2023) Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. International Journal of Molecular Sciences. 24(4):
|
Swaminathan, A., Hassan-Abdi, R., Renault, S., Siekierska, A., Riché, R., Liao, M., de Witte, P.A.M., Yanicostas, C., Soussi-Yanicostas, N., Drapeau, P., Samarut, É. (2018) Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development. Current biology : CB. 28(12):1924-1937.e5
|
Torres-Hernández, B.A., Colón, L.R., Rosa-Falero, C., Torrado, A., Miscalichi, N., Ortíz, J.G., González-Sepúlveda, L., Pérez-Ríos, N., Suárez-Pérez, E., Bradsher, J.N., Behra, M. (2016) Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract. Psychopharmacology. 233(13):2533-47
|
Valderrama, B., Daly, I., Gunnigle, E., O'Riordan, K.J., Chichlowski, M., Banerjee, S., Skowronski, A.A., Pandey, N., Cryan, J.F., Clarke, G., Nagpal, J. (2025) From in silico screening to in vivo validation in zebrafish - a framework for reeling in the right psychobiotics. Food & function. :
|
Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
|
Vossen, L.E., Cerveny, D., Österkrans, M., Thörnqvist, P.O., Jutfelt, F., Fick, J., Brodin, T., Winberg, S. (2020) Chronic exposure to oxazepam pollution produces tolerance to anxiolytic effects in zebrafish (Danio rerio). Environmental science & technology. 54(3):1760-1769
|
Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
|
Wang, H., Meng, Z., Liu, F., Zhou, L., Su, M., Meng, Y., Zhang, S., Liao, X., Cao, Z., Lu, H. (2019) Characterization of boscalid-induced oxidative stress and neurodevelopmental toxicity in zebrafish embryos. Chemosphere. 238:124753
|
Wang, H., Zhou, L., Meng, Z., Su, M., Zhang, S., Huang, P., Jiang, F., Liao, X., Cao, Z., Lu, H. (2019) Clethodim exposure induced development toxicity and behaviour alteration in early stages of zebrafish life. Environmental pollution (Barking, Essex : 1987). 255:113218
|
Wang, H.T., Fu, X.T., Wang, Y.F., Liu, L.Y., Liu, Z.Z., Xu, H.A. (2025) Chd8 Deficiency in Zebrafish Causes Autism-Like Behavioral Deficits. Journal of Integrative Neuroscience. 24:4441444414
|
Wang, X., Liao, Q., Chen, H., Gong, G., Siu, S.W.I., Chen, Q., Kam, H., Ung, C.O.L., Cheung, K.K., Rádis-Baptista, G., Wong, C.T.T., Lee, S.M. (2021) Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae. Frontiers in pharmacology. 12:763089
|
Wang, X., Zhang, J., Rao, X., Liu, Y., Lin, Z., Chen, F., Luo, R., Sun, H., Gan, J. (2025) Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis. Chinese Medical Journal. :
|
Wang, Y., Liu, C., Deng, J., Xu, Q., Lin, J., Li, H., Hu, M., Hu, C., Li, Q., Xu, X. (2023) Behavioral and Sensory Deficits Associated with Dysfunction of GABAergic System in a Novel shank2-Deficient Zebrafish Model. International Journal of Molecular Sciences. 24(3):
|
Wang, Y., Shen, C., Wang, C., Zhou, Y., Gao, D., Zuo, Z. (2017) Maternal and embryonic exposure to the water soluble fraction of crude oil or lead induces behavioral abnormalities in zebrafish (Danio rerio), and the mechanisms involved. Chemosphere. 191:7-16
|
|
|
Zhang, B., Zhang, L., He, L., Yang, X., Shi, Y., Liao, S., Yang, S., Cheng, J., Ren, T. (2018) Interactions of Fipronil within Fish and Insects: Experimental and Molecular Modeling Studies. Journal of Agricultural and Food Chemistry. 66:5756-5761
|
Zhao, Y., Sun, Q., Hu, K., Ruan, J., Yang, X. (2016) Isolation, characterization, and tissue-specific expression of GABA A receptor α1 subunit gene of Carassius auratus gibelio after avermectin treatment. Fish physiology and biochemistry. 42(1):83-92
|
Zhou, J., Liang, W., Wang, J., Chen, J., Liu, D., Wang, X., Wu, Y., Zhang, Q., Shen, D. (2021) An epileptic encephalopathy associated GABRG2 missense mutation leads to pre- and postsynaptic defects in zebrafish. Human molecular genetics. 31(19):3216-3230
|