ZFIN

ZFIN ID: ZDB-GENE-060607-11

ZFIN ID: ZDB-GENE-060607-11

CITATIONS (70 total)

Gene Name:	endothelial PAS domain protein 1b
Gene Symbol:	epas1b

Liao, Q., Deng, H., Wang, Z., Yu, G., Zhu, C., Jia, S., Liu, W., Bai, Y., Sun, X., Chen, X., Xiao, W., Liu, X. (2023) Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(12):105420

Liao, Q., Zhu, C., Sun, X., Wang, Z., Chen, X., Deng, H., Tang, J., Jia, S., Liu, W., Xiao, W., Liu, X. (2023) Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance. The Journal of biological chemistry. 299(8):105074

Liu, Q., Song, T., Chen, B., Zhang, J., Li, W. (2023) Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22874e22874

Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010

Zhang, R., Ma, Z., Wang, J., Fan, C. (2023) HIF signaling overactivation inhibits lateral line neuromast development through Wnt in zebrafish. Gene. 898:148077

Chung, H.Y., Lin, B.A., Lin, Y.X., Chang, C.W., Tzou, W.S., Pei, T.W., Hu, C.H. (2021) Meis1, Hi1α, and GATA1 are integrated into a hierarchical regulatory network to mediate primitive erythropoiesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21915

He, L., Zhang, Q., Jiang, D., Zhang, Y., Wei, Y., Yang, Y., Li, N., Wang, S., Yue, Y., Zhao, Q. (2021) Zebrafish foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression. Journal of genetics and genomics = Yi chuan xue bao. 49(6):559-568

Li, H., Nam, Y., Huo, R., Fu, W., Biaobin, J., Zhou, Q., Song, D., Yang, Y., Jiao, Y., Weng, J., Yan, Z., Di, L., Li, J., Wang, J., Xu, H., Wang, S., Zhao, J., Wen, Z., Jiguang, W., Cao, Y. (2021) De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation. Circulation research. 129(9):825-839

Liu, C.C., Shih, T.C., Pai, T.W., Hu, C.H., Tzou, W.S. (2021) Enhanced Over-Representation Analysis for the Differential Regulation of Birc5a and HIF2α-Knockdown Approaches. Journal of computational biology : a journal of computational molecular cell biology. 28(7):674-686

Wu, S., Chen, K., Xu, T., Ma, K., Gao, L., Fu, C., Zhang, W., Jing, C., Ren, C., Deng, M., Chen, Y., Zhou, Y., Pan, W., Jia, X. (2021) Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Frontiers in cell and developmental biology. 9:709923

Lin, Y.C., Wu, C.Y., Hu, C.H., Pai, T.W., Chen, Y.R., Wang, W.D. (2020) Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos. Antioxidants (Basel, Switzerland). 9(8)

Das, T., Soren, K., Yerasi, M., Kumar, A., Chakravarty, S. (2019) Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model. Neuroscience letters. 712:134492

El-Brolosy, M.A., Kontarakis, Z., Rossi, A., Kuenne, C., Günther, S., Fukuda, N., Kikhi, K., Boezio, G.L.M., Takacs, C.M., Lai, S.L., Fukuda, R., Gerri, C., Giraldez, A.J., Stainier, D.Y.R. (2019) Genetic compensation triggered by mutant mRNA degradation. Nature. 568(7751):193-197

Ma, Q., Hu, C.T., Yue, J., Luo, Y., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2019) High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish. Fish physiology and biochemistry. 46(2):665-679

Tai, Z., Guan, P., Wang, Z., Li, L., Zhang, T., Li, G., Liu, J.X. (2019) Common responses of fish embryos to metals: an integrated analysis of transcriptomes and methylomes in zebrafish embryos under the stress of copper ions or silver nanoparticles. Metallomics : integrated biometal science. 11(9):1452-1464

Zhang, Z., Ran, C., Ding, Q.W., Liu, H.L., Xie, M.X., Yang, Y.L., Xie, Y.D., Gao, C.C., Zhang, H.L., Zhou, Z.G. (2019) Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish. Communications biology. 2:274

Gerri, C., Marass, M., Rossi, A., Stainier, D.Y.R. (2018) Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish. Blood. 131(9):963-973

Xiao, W., Cai, X., Zhang, D., Wang, J., Liu, X., Ouyang, G. (2018) Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish.. The Journal of biological chemistry. 293(40):15370-15380

Binelli, A., Del Giacco, L., Santo, N., Bini, L., Magni, S., Parolini, M., Madaschi, L., Ghilardi, A., Maggioni, D., Ascagni, M., Armini, A., Prosperi, L., Landi, C., La Porta, C., Della Torre, C. (2017) Carbon nanopowder acts as a Trojan-horse for benzo(α)pyrene in Danio rerio embryos. Nanotoxicology. 11(3):371-381

Ma, J., Evrard, S., Badiola, I., Siegfried, G., Khatib, A.M. (2017) Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF). European journal of cell biology. 96(5):457-468

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Feng, N., Chen, H., Fu, S., Bian, Z., Lin, X., Yang, L., Gao, Y., Fang, J., Ge, Z. (2016) HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide. Scientific Reports. 6:27280

Khatib, A.M., Lahlil, R., Hagedorn, M., Delomenie, C., Christophe, O., Denis, C., Siegfried, G. (2016) Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis. Oncotarget. 7(11):12102-20

Lai, Y.R., Lu, Y.F., Lien, H.W., Huang, C.J., Hwang, S.L. (2016) Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos. The Biochemical journal. 473(14):2205-18

Lien, H.W., Yuan, R.Y., Chou, C.M., Chen, Y.C., Hung, C.C., Hu, C.H., Hwang, S.P., Hwang, P.P., Shen, C.N., Chen, C.L., Cheng, C.H., Huang, C.J. (2016) Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α. Scientific Reports. 6:28297

Köblitz, L., Fiechtner, B., Baus, K., Lussnig, R., Pelster, B. (2015) Developmental Expression and Hypoxic Induction of Hypoxia Inducible Transcription Factors in the Zebrafish. PLoS One. 10:e0128938

Martins Metelo, A., Noonan, H.R., Xiang, L., Jin, Y., Baker, R., Kamentsky, L., Zhang, Y., van Rooijen, E., Shin, J., Carpenter, A.E., Yeh, J.R., Peterson, R.T., Iliopoulos, O. (2015) Pharmacological HIF2α inhibition improves VHL disease–associated phenotypes in zebrafish model. J. Clin. Invest.. 125(5):1987-97

Pelster, B., Egg, M. (2015) Multiplicity of Hypoxia-Inducible Transcription Factors and Their Connection to the Circadian Clock in the Zebrafish *. Physiological and biochemical zoology : PBZ. 88:146-157

Wang, Y., Yang, L., Zhou, K., Zhang, Y., Song, Z., He, S. (2015) Evidence for adaptation to the Tibetan Plateau inferred from Tibetan loach transcriptomes. Genome biology and evolution. 7(11):2970-82

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

Guan, L., Chi, W., Xiao, W., Chen, L., He, S. (2014) Analysis of hypoxia-inducible factor alpha polyploidization reveals adaptation to Tibetan Plateau in the evolution of schizothoracine fish. BMC Evolutionary Biology. 14:192

Lin, T.Y., Chou, C.F., Chung, H.Y., Chiang, C.Y., Li, C.H., Wu, J.L., Lin, H.J., Pai, T.W., Hu, C.H., Tzou, W.S. (2014) Hypoxia-Inducible Factor 2 Alpha Is Essential for Hepatic Outgrowth and Functions via the Regulation of leg1 Transcription in the Zebrafish Embryo. PLoS One. 9:e101980

Rytkönen, K.T., Prokkola, J.M., Salonen, V., Nikinmaa, M. (2014) Transcriptional divergence of the duplicated hypoxia-inducible factor alpha genes in zebrafish. Gene. 541:60-6

Thompson, A.A., Elks, P.M., Marriott, H.M., Eamsamarng, S., Higgins, K.R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E.E., Formenti, F., Van Eeden, F.J., Kinnula, V.L., Pugh, C.W., Sabroe, I., Dockrell, D.H., Chilvers, E.R., Robbins, P.A., Percy, M.J., Simon, M.C., Johnson, R.S., Renshaw, S.A., Whyte, M.K., and Walmsley, S.R. (2014) Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 123(3):366-76

Zhang, P., Yao, Q., Lu, L., Li, Y., Chen, P.J., Duan, C. (2014) Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Reports. 6:1110-21

Rytkönen, K.T., Akbarzadeh, A., Miandare, H.K., Kamei, H., Duan, C., Leder, E.H., Williams, T.A., and Nikinmaa, M. (2013) SUBFUNCTIONALIZATION OF CYPRINID HYPOXIA-INDUCIBLE FACTORS FOR ROLES IN DEVELOPMENT AND OXYGEN SENSING. Evolution; international journal of organic evolution. 67(3):873-882

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Cade, L., Reyon, D., Hwang, W.Y., Tsai, S.Q., Patel, S., Khayter, C., Joung, J.K., Sander, J.D., Peterson, R.T., and Yeh, J.R. (2012) Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic acids research. 40(16):8001-8010

Ko, C.Y., Tsai, M.Y., Tseng, W.F., Cheng, C.H., Huang, C.R., Wu, J.S., Chung, H.Y., Hsieh, C.S., Sun, C.K., Hwang, S.P., Yuh, C.H., Huang, C.J., Pai, T.W., Tzou, W.S., and Hu, C.H. (2011) Integration of CNS survival and differentiation by HIF2α. Cell death and differentiation. 18(11):1757-70

Kopp, R., Köblitz, L., Egg, M., and Pelster, B. (2011) HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably. Physiological Genomics. 43(9):506-516

Hyvarinen, J., Parikka, M., Sormunen, R., Ramet, M., Tryggvason, K., Kivirikko, K.I., Myllyharju, J., and Koivunen, P. (2010) Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. The Journal of biological chemistry. 285(53):42023-42032

Kopp, R., Schwerte, T., Egg, M., Sandbichler, A.M., Egger, B., and Pelster, B. (2010) Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. Physiological Genomics. 42(1):8-23

Wang, Y., Chen, K., Yao, Q., Zheng, X., and Yang, Z. (2009) Phylogenetic Analysis of Zebrafish Basic Helix-Loop-Helix Transcription Factors. Journal of molecular evolution. 68(6):629-640

Hsieh, C.S., Ko, C.Y., Chen, S.Y., Liu, T.M., Wu, J.S., Hu, C.H., and Sun, C.K. (2008) In vivo long-term continuous observation of gene expression in zebrafish embryo nerve systems by using harmonic generation microscopy and morphant technology. Journal of Biomedical Optics. 13(6):064041

Rojas, D.A., Perez-Munizaga, D.A., Centanin, L., Antonelli, M., Wappner, P., Allende, M.L., and Reyes, A.E. (2007) Cloning of hif-1alpha and hif-2alpha and mRNA expression pattern during development in zebrafish. Gene expression patterns : GEP. 7(3):339-345

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (23):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Rauch, G.J., Lyons, D.A., Middendorf, I., Friedlander, B., Arana, N., Reyes, T., and Talbot, W.S. (2003) Submission and Curation of Gene Expression Data. ZFIN Direct Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.