ZFIN

ZFIN ID: ZDB-GENE-041210-183

CITATIONS (71 total)

Gene Name:	leptin b
Gene Symbol:	lepb

Boyd, P., Campbell, L.J., Hyde, D.R. (2023) Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina. Frontiers in cell and developmental biology. 11:11425861142586

Eeza, M.N.H., Singer, R., Ding, Y., He, J., Zuberi, Z., Baelde, H.J., de Groot, H.J.M., Matysik, J., Spaink, H.P., Alia, A. (2023) Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging. PLoS One. 18:e0284215e0284215

Lu, F., Leach, L.L., Gross, J.M. (2023) A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports. 13:31423142

Lv, H., Jin, Z., Wang, D., Guo, X., Wang, H., Yang, S. (2023) Erk5 functions in modulation of zebrafish intestinal permeability. Cell and tissue research. 393(2):281-296

Wei, Z., Bagivalu Lakshminarasimha, A., Cone, R., Michel, M. (2023) Loss of Agrp1 in zebrafish: Effects on the growth and reproductive axis. General and comparative endocrinology. 336:114243

Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300

Ding, Y., Haks, M.C., van den Eeden, S.J.F., Ottenhoff, T.H.M., Harms, A.C., Hankemeier, T., Eeza, M.N.H., Matysik, J., Alia, A., Spaink, H.P. (2022) Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome. Metabolomics : Official journal of the Metabolomic Society. 18:67

Hu, Z., Ai, N., Chen, W., Wong, Q.W., Ge, W. (2022) Leptin and Its Signaling Are Not Involved in Zebrafish Puberty Onset. Biology of reproduction. 106(5):928-942

Kamstra, K., Rizwan, M.Z., Grattan, D.R., Horsfield, J.A., Tups, A. (2022) Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22207

Lu, F., Leach, L.L., Gross, J.M. (2022) mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish. PLoS Genetics. 18:e1009628

Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801

Shin, K., Begeman, I.J., Cao, J., Kang, J. (2022) leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):91-106

Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595

Ding, Y., Haks, M.C., Forn-Cuní, G., He, J., Nowik, N., Harms, A.C., Hankemeier, T., Eeza, M.N.H., Matysik, J., Alia, A., Spaink, H.P. (2021) Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways. Cell & Bioscience. 11:126

Geng, F., Ma, J., Li, X., Hu, Z., Zhang, R. (2021) Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration. International Journal of Molecular Sciences. 22(8):

He, J., Ding, Y., Nowik, N., Jager, C., H Eeza, M.N., Alia, A., Baelde, H.J., Spaink, H.P. (2021) Leptin deficiency affects glucose homeostasis and results in adiposity in zebrafish. The Journal of endocrinology. 249(2):125-134

Lutfi, E., Basili, D., Falcinelli, S., Morillas, L., Carnevali, O., Capilla, E., Navarro, I. (2021) The probiotic Lactobacillus rhamnosus mimics the dark-driven regulation of appetite markers and melatonin receptors' expression in zebrafish (Danio rerio) larvae: Understanding the role of the gut microbiome. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 256:110634

Zhou, Y., Guo, W., Lei, L., Sun, Y., Li, R., Guo, Y., Yang, L., Shi, X., Han, J., Zhou, B. (2021) Bis(2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial composition. Environmental pollution (Barking, Essex : 1987). 290:118127

Begeman, I.J., Shin, K., Osorio-Méndez, D., Kurth, A., Lee, N., Chamberlain, T.J., Pelegri, F.J., Kang, J. (2020) Decoding an Organ Regeneration Switch by Dissecting Cardiac Regeneration Enhancers. Development (Cambridge, England). 147(24):

Blanco, A.M., Bertucci, J.I., Hatef, A., Unniappan, S. (2020) Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Scientific Reports. 10:10727

Blanco, A.M., Bertucci, J.I., Unniappan, S. (2020) FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. Scientific Reports. 10:6993

Chen, A., Han, Y., Poss, K.D. (2020) Regulation of Zebrafish Fin Regeneration by Vitamin D Signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(9):1330-1339

Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738

Fei, F., Sun, S., Li, Q., Pei, Z., Wang, L., Zhang, R., Luo, F., Yu, M., Wang, X. (2020) Combinatorial normalization of liver-derived cytokine pathways alleviates hepatic tumor-associated cachexia in zebrafish. Cancer research. 81(4):873-884

Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52

Lee, M., Wan, J., Goldman, D. (2020) Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. eLIFE. 9:

Thompson, J.D., Ou, J., Lee, N., Shin, K., Cigliola, V., Song, L., Crawford, G.E., Kang, J., Poss, K.D. (2020) Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. Development (Cambridge, England). 147(14):

Zhu, Q.S., Wang, J., He, S., Liang, X.F., Xie, S., Xiao, Q.Q. (2020) Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Nutrition & metabolism. 17:67

Faught, E., Vijayan, M.M. (2019) Postnatal triglyceride accumulation is regulated by the mineralocorticoid receptor under basal and stress conditions. The Journal of physiology. 597(19):4927-4941

Levitas-Djerbi, T., Sagi, D., Lebenthal-Loinger, I., Lerer-Goldshtein, T., Appelbaum, L. (2019) Neurotensin Enhances Locomotor Activity and Arousal, and Inhibits Melanin-Concentrating Hormone Signalings. Neuroendocrinology. 110(1-2):35-49

Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Ramachandran, R. (2019) Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish. Life science alliance. 2(5):

Zhang, Z., Hou, H., Yu, S., Zhou, C., Zhang, X., Li, N., Zhang, S., Song, K., Lu, Y., Liu, D., Lu, H., Xu, H. (2019) Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia. 68(1):111-127

Elsaeidi, F., Macpherson, P., Mills, E.A., Jui, J., Flannery, J.G., Goldman, D. (2018) Notch suppression collaborates with Ascl1 and Lin28 to unleash a regenerative response in fish retina, but not in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(9):2246-2261

Enya, S., Kawakami, K., Suzuki, Y., Kawaoka, S. (2018) A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in causing adverse effects on the host.. Disease models & mechanisms. 11(8)

Löhr, H., Hess, S., Pereira, M.M.A., Reinoß, P., Leibold, S., Schenkel, C., Wunderlich, C.M., Kloppenburg, P., Brüning, J.C., Hammerschmidt, M. (2018) Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit. Cell Reports. 23:1728-1741

Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84

Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11

Van Gennip, J.L.M., Boswell, C.W., Ciruna, B. (2018) Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Science advances. 4:eaav1781

Mania, M., Maruccio, L., Russo, F., Abbate, F., Castaldo, L., D'Angelo, L., de Girolamo, P., Guerrera, M.C., Lucini, C., Madrigrano, M., Levanti, M., Germanà, A. (2017) Expression and distribution of leptin and its receptors in the digestive tract of DIO (diet-induced obese) zebrafish. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 212:37-47

Schultz, L.E., Solin, S.L., Wierson, W.A., Lovan, J.M., Syrkin-Nikolau, J., Lincow, D.E., Severin, A.J., Sakaguchi, D.S., McGrail, M. (2017) Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors. Zebrafish. 14(4):343-356

Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770

Yu, M., Feng, Y., Zhang, X., Wang, J., Tian, H., Wang, W., Ru, S. (2017) Semicarbazide disturbs the reproductive system of male zebrafish (Danio rerio) through the GABAergic system. Reproductive toxicology (Elmsford, N.Y.). 73:149-157

Kang, J., Hu, J., Karra, R., Dickson, A.L., Tornini, V.A., Nachtrab, G., Gemberling, M., Goldman, J.A., Black, B.L., Poss, K.D. (2016) Modulation of tissue repair by regeneration enhancer elements. Nature. 532(7598):201-6

Khatib, A.M., Lahlil, R., Hagedorn, M., Delomenie, C., Christophe, O., Denis, C., Siegfried, G. (2016) Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis. Oncotarget. 7(11):12102-20

Michel, M., Page-McCaw, P.S., Chen, W., Cone, R.D. (2016) Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 113(11):3084-9

Yu, M., Zhang, X., Guo, L., Tian, H., Wang, W., Ru, S. (2016) Anti-estrogenic effect of semicarbazide in female zebrafish (Danio rerio) and its potential mechanisms. Aquatic toxicology (Amsterdam, Netherlands). 170:262-270

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Veneman, W.J., de Sonneville, J., van der Kolk, K.J., Ordas, A., Al-Ars, Z., Meijer, A.H., Spaink, H.P. (2015) Analysis of RNAseq datasets from a comparative infectious disease zebrafish model using GeneTiles bioinformatics. Immunogenetics. 67(3):135-47

Xu, T., Zhao, J., Yin, D., Zhao, Q., Dong, B. (2015) High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae. BMC Genomics. 16:23

Marín-Juez, R., Jong-Raadsen, S., Yang, S., Spaink, H.P. (2014) Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. The Journal of endocrinology. 222(2):229-41

Zhao, X.F., Wan, J., Powell, C., Ramachandran, R., Myers, M.G., Goldman, D. (2014) Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration. Cell Reports. 9(1):272-84

Prokop, J.W., Duff, R.J., Ball, H.C., Copeland, D.L., and Londraville, R.L. (2012) Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides. 38(2):326-336

Gorissen, M., Bernier, N., Nabuurs, S., Flik, G., and Huising, M. (2009) Two divergent leptin paralogues in zebrafish (Danio rerio) that originate early in teleostean evolution. The Journal of endocrinology. 201(3):329-339

Additional Citations (18):

Zebrafish Nomenclature Committee (2023) Nomenclature Data Curation (2023). Nomenclature Committee Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2020) Nomenclature Data Curation (2020). Nomenclature Committee Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Varshney, G.K., Zhang, S., Burgess, S.M., ZFIN Staff (2015) Automated Data Load From CRISPRz. ZFIN Direct Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) Temporary Manual Curation. Manually curated data.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.