Gene
lepb
- ID
- ZDB-GENE-041210-183
- Name
- leptin b
- Symbol
- lepb Nomenclature History
- Previous Names
-
- si:dkey-21o22.1
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Acts upstream of or within several processes, including glucose homeostasis; regulation of glucose metabolic process; and response to starvation. Predicted to be located in extracellular region. Is expressed in digestive system; gill; heart; hypophysis; and pleuroperitoneal region. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (leptin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital leptin deficiency | Alliance | Obesity, morbid, due to leptin deficiency | 614962 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| type 2 diabetes mellitus | lepbibl54/ibl54 (AB/TL) | standard conditions | He et al., 2021 |
| type 2 diabetes mellitus | lepbibl55/ibl55 (AB/TL) | standard conditions | He et al., 2021 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Four-helical cytokine-like, core | Leptin |
|---|---|---|---|
|
UniProtKB:C4WYH6
|
168 |
Interactions and Pathways
No data available
Plasmids
No data available