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Phenotype Figure Summary
Marker:
rpgra
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Ren
et al.
, 2025
Figure 1.
rpgra
zf4007/zf4007
retina photoreceptor outer segment decreased length, abnormal
retinal outer nuclear layer decreased thickness, abnormal
retinal pigmented epithelium Ab1-rpgra labeling absent, abnormal
retinal pigmented epithelium cell shape, abnormal
retinal pigmented epithelium cell-cell junction structurally discontinuous, abnormal
retinal pigmented epithelium nucleus morphology, abnormal
Figure 2.
rpgra
zf4007/zf4007
retinal pigmented epithelium lipid droplet increased amount, abnormal
retinal pigmented epithelium lipid droplet increased diameter, abnormal
retinal pigmented epithelium triglyceride increased amount, abnormal
Figure 4.
rpgra
zf4007/zf4007
retinal pigmented epithelium Ab2-lamp2 labeling decreased amount, abnormal
retinal pigmented epithelium Ab2-rab7 labeling decreased amount, abnormal
retinal pigmented epithelium Ab3-ctsb labeling decreased amount, abnormal
retinal pigmented epithelium Ab8-lamp1 labeling decreased amount, abnormal
retinal pigmented epithelium lipid droplet increased amount, abnormal
retinal pigmented epithelium lysosome morphology, abnormal
retinal pigmented epithelium lysosome organization decreased process quality, abnormal
retinal pigmented epithelium phagolysosome increased amount, abnormal
Figure 5.
rpgra
zf4007/zf4007
retinal pigmented epithelium lysosomal lumen acidification decreased process quality, abnormal
retinal pigmented epithelium lysosome Ab8-lamp1 labeling decreased distribution, abnormal
retinal pigmented epithelium lysosome organization decreased process quality, abnormal
Gerner
et al.
, 2010
Fig. 1
WT + MO2-rpgra
brain hydrocephalic, abnormal
eye decreased size, abnormal
midbrain hindbrain boundary decreased thickness, abnormal
renal system cystic, abnormal
whole organism anterior-posterior axis decreased length, abnormal
whole organism anterior-posterior axis increased curvature, abnormal
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