Publication	Data		Fish	Anatomy
Wrighton et al., 2021	Fig. 6		zf3335Tg + MO2-vhl	muscle mitophagy increased occurrence, abnormal
Kim et al., 2020	Fig. 1		vhlhu2117/hu2117; sh144Tg	angiogenesis increased occurrence, abnormal erythrocyte differentiation increased occurrence, abnormal respiratory gaseous exchange by respiratory system increased occurrence, abnormal
	Table 1		vhlhu2117/hu2117	whole organism alas2 expression increased amount, abnormal whole organism egln3 expression increased amount, abnormal whole organism gata1a expression increased amount, abnormal whole organism mknk2b expression increased amount, abnormal whole organism vegfaa expression increased amount, abnormal
Marchi et al., 2020	Fig. 1		vhlhu2117/hu2117; sh144Tg/sh144Tg	pericardium edematous, abnormal trunk vasculature mislocalised, abnormal whole organism hypoxia-inducible factor-1alpha signaling pathway increased efficacy, abnormal
	Fig. 2		vhlhu2117/hu2117; sh144Tg/sh144Tg	adenohypophysis pomca expression decreased amount, abnormal whole organism cortisol decreased amount, abnormal
	Fig. 3		vhlhu2117/hu2117; sh144Tg/sh144Tg	pericardium edematous, abnormal trunk vasculature mislocalised, abnormal
	Fig. 4		vhlhu2117/hu2117; sh144Tg/sh144Tg	adenohypophysis pomca expression decreased amount, abnormal pericardium edematous, abnormal trunk vasculature mislocalised, abnormal
	Fig. 5		vhlhu2117/hu2117; sh144Tg/sh144Tg ,   vhlhu2117/hu2117	head egln3 expression increased amount, abnormal head ldha expression increased amount, abnormal kidney egln3 expression increased amount, abnormal liver ldha expression increased amount, abnormal
	Fig. 6		vhlhu2117/hu2117; sh144Tg/sh144Tg	whole organism hypoxia-inducible factor-1alpha signaling pathway increased efficacy, abnormal
Ward et al., 2019	Fig. 1		vhlhu2117/hu2117; y1Tg	heart edematous, abnormal swim bladder uninflated, abnormal yolk edematous, abnormal
	Fig. 2		vhlhu2117/hu2117; y1Tg	optomotor response decreased occurrence, abnormal retina detached from optic choroid, abnormal retina edematous, abnormal retinal ganglion cell layer decreased thickness, abnormal retinal pigmented epithelium increased thickness, abnormal whole organism response to light intensity decreased occurrence, abnormal
	Fig. 3		vhlhu2117/hu2117; y1Tg	eye has fewer parts of type hyaloid vessel, abnormal hyaloid vessel angiogenesis process quality, abnormal hyaloid vessel malformed, abnormal retinal blood vessel morphogenesis process quality, abnormal retinal ganglion cell layer has extra parts of type hyaloid vessel, abnormal retinal ganglion cell layer hyaloid vessel mislocalised, abnormal retinal inner plexiform layer has extra parts of type hyaloid vessel, abnormal retinal inner plexiform layer hyaloid vessel mislocalised, abnormal
	Fig. 4		vhlhu2117/hu2117; y1Tg	eye kdrl expression increased amount, abnormal eye vegfaa expression increased amount, abnormal eye vegfab expression increased amount, abnormal optomotor response decreased occurrence, abnormal
	Fig. 5		vhlhu2117/hu2117; y1Tg	eye has fewer parts of type hyaloid vessel, abnormal hyaloid vessel malformed, abnormal hyaloid vessel retinal blood vessel morphogenesis process quality, abnormal retinal ganglion cell layer has extra parts of type hyaloid vessel, abnormal retinal ganglion cell layer hyaloid vessel mislocalised, abnormal retinal inner plexiform layer has extra parts of type hyaloid vessel, abnormal retinal inner plexiform layer hyaloid vessel mislocalised, abnormal
Greenhough et al., 2018	2		vhlhu2117/hu2117; y1Tg	angiogenesis increased occurrence, abnormal vasculature EGFP expression increased distribution, abnormal whole organism gprc5ba expression increased amount, abnormal whole organism plod1a expression increased amount, abnormal
van Rooijen et al., 2018	Fig. 1		vhlhu2081/+; vhlhu2117/+ ,   vhlhu2117/hu2117 ,   vhlhu2081/hu2081	pronephric proximal convoluted tubule cell botryoidal, abnormal pronephric proximal straight tubule cell botryoidal, abnormal pronephros development decreased process quality, abnormal
	Fig. 2		vhlhu2081/+; vhlhu2117/+ ,   vhlhu2117/hu2117 ,   vhlhu2081/hu2081	capillary loop nephron cxcr4a expression increased amount, abnormal capillary loop nephron dilated, abnormal pronephric capsular space increased width, abnormal pronephric glomerulus increased size, abnormal pronephric podocyte cxcr4a expression increased amount, abnormal pronephros development decreased process quality, abnormal
	Fig. 3		vhlhu2081/+; vhlhu2117/+ ,   vhlhu2117/hu2117 ,   vhlhu2081/hu2081	pronephric proximal convoluted tubule cytoplasm has extra parts of type pronephric proximal convoluted tubule vesicle, abnormal pronephric proximal convoluted tubule vesicle increased variability of size, abnormal pronephros development decreased process quality, abnormal
	Fig. 4		vhlhu2081/+; vhlhu2117/+; s843Tg ,   vhlhu2117/hu2117; s843Tg ,   vhlhu2081/hu2081; s843Tg	pronephric proximal convoluted tubule blood vessel morphogenesis increased occurrence, abnormal pronephric proximal convoluted tubule renal system vasculature morphogenesis increased occurrence, abnormal pronephric proximal straight tubule blood vessel morphogenesis increased occurrence, abnormal pronephric proximal straight tubule renal system vasculature morphogenesis increased occurrence, abnormal
	Fig. 5		vhlhu2081/+; vhlhu2117/+; s843Tg ,   vhlhu2117/hu2117; s843Tg ,   vhlhu2081/hu2081; s843Tg	pronephric proximal convoluted tubule endocytosis increased occurrence, abnormal pronephric proximal straight tubule endocytosis increased occurrence, abnormal
Lim et al., 2017	Fig. 1		WT + MO2-vhl	whole organism pdgfba expression increased amount, abnormal whole organism pdgfrb expression increased amount, abnormal
	Fig. 2		WT + MO2-vhl ,   la2Tg; sd2Tg + MO2-vhl	hematopoietic multipotent progenitor cell increased amount, abnormal ventral wall of dorsal aorta hematopoietic stem cell myb expression increased amount, abnormal ventral wall of dorsal aorta hematopoietic stem cell runx1 expression increased amount, abnormal
Wild et al., 2017	Fig. 5		vhlhu2117/hu2117; s843Tg	intersegmental vein vascular sprouts increased amount, abnormal intersegmental vessel dorsal region increased branchiness, abnormal
	Fig. 7		zf148Tg + MO1-vhl	neuron vegfaa expression increased amount, abnormal
Noonan et al., 2016	Fig. 1		vhlhu2117/hu2117	pronephric proximal convoluted tubule apical-basal polarity, abnormal pronephric proximal convoluted tubule cytoplasmic vesicle increased amount, abnormal pronephric proximal convoluted tubule epithelial cell decreased amount, abnormal pronephric proximal convoluted tubule increased diameter, abnormal pronephric proximal straight tubule apical-basal polarity, abnormal pronephric proximal straight tubule cytoplasmic vesicle increased amount, abnormal pronephric proximal straight tubule epithelial cell decreased amount, abnormal pronephric proximal straight tubule increased diameter, abnormal
	Fig. 2		vhlhu2117/hu2117	pronephric proximal convoluted tubule ciliated epithelial cell disorganized, abnormal pronephric proximal convoluted tubule increased diameter, abnormal pronephric proximal straight tubule ciliated epithelial cell disorganized, abnormal pronephric proximal straight tubule increased diameter, abnormal
	Fig. 5		vhlhu2117/hu2117; zf34Tg	pronephric proximal convoluted tubule cell population proliferation increased occurrence, abnormal pronephric proximal straight tubule cell population proliferation increased occurrence, abnormal
	Fig. 6		vhlhu2117/hu2117; zf34Tg	pronephric proximal convoluted tubule apoptotic process increased occurrence, abnormal pronephric proximal straight tubule apoptotic process increased occurrence, abnormal
	Fig. 7		vhlhu2117/hu2117	pronephric proximal convoluted tubule ciliated epithelial cell disorganized, abnormal pronephric proximal convoluted tubule cytoplasmic vesicle increased amount, abnormal pronephric proximal convoluted tubule epithelial cell decreased amount, abnormal pronephric proximal convoluted tubule increased diameter, abnormal pronephric proximal straight tubule ciliated epithelial cell disorganized, abnormal pronephric proximal straight tubule cytoplasmic vesicle increased amount, abnormal pronephric proximal straight tubule epithelial cell decreased amount, abnormal pronephric proximal straight tubule increased diameter, abnormal
Chen et al., 2015	Fig. 1		li1Tg + MO2-vhl	pronephric duct curved, abnormal pronephric duct cystic, abnormal pronephric glomerulus atrophied, abnormal pronephric glomerulus cystic, abnormal pronephric glomerulus swollen, abnormal pronephric tubule curved, abnormal pronephric tubule cystic, abnormal pronephric tubule distended, abnormal pronephros development disrupted, abnormal
	Fig. 2		WT + MO2-vhl	glomerular filtration disrupted, abnormal pronephros decreased functionality, abnormal
	Fig. 3		WT + MO2-vhl	pronephric glomerulus bicellular tight junction decreased amount, abnormal pronephric glomerulus disorganized, abnormal
	Fig. 4		WT + MO2-vhl	blood increased accumulation yolk, abnormal subintestinal vein increased branchiness, abnormal subintestinal vein spatial pattern, abnormal subintestinal vein sprouting angiogenesis increased occurrence, abnormal whole organism epor expression increased amount, abnormal whole organism kdrl expression increased amount, abnormal whole organism vegfaa expression increased amount, abnormal
	Fig. 5		WT + MO2-vhl	dorsal aorta dilated, abnormal lateral dorsal aorta dilated, abnormal podocyte vegfaa expression increased amount, abnormal pronephric glomerulus increased size, abnormal pronephros development disrupted, abnormal pronephros shape, abnormal
Du et al., 2015	Fig. 6		vhlihb2015001/ihb2015001 ,   vhlihb2015001/+	whole organism ifnphi1 expression increased amount, abnormal whole organism mavs expression increased amount, abnormal
	Fig. S3		vhlihb2015001/ihb2015001	nucleate erythrocyte increased amount, abnormal regulation of respiratory gaseous exchange increased occurrence, abnormal respiratory gaseous exchange by respiratory system increased occurrence, abnormal
Essers et al., 2015	Fig. 1		vhlhu2117/hu2117	whole organism Ab14-tp53 labeling increased amount, abnormal
	Fig. 3		vhlhu2117/hu2117	whole organism Ab2-mdm2 labeling decreased amount, abnormal
	Fig. 4		vhlhu2117/hu2117	whole organism birc5a expression increased amount, abnormal
Jensen et al., 2015	Fig. 7		vhlhu2081/hu2081	head vegfaa expression increased amount, abnormal
Martins Metelo et al., 2015	Fig. 4		vhlhu2117/hu2117	angiogenesis increased process quality, abnormal erythrocyte differentiation increased process quality, abnormal
	Fig. 5		vhlhu2117/hu2117; y1Tg ,   vhlhu2117/hu2117	angiogenesis increased process quality, abnormal brain vasculature morphology, abnormal erythrocyte differentiation increased process quality, abnormal ocular blood vessel morphology, abnormal trunk vasculature morphology, abnormal
	Fig. 6		vhlhu2117/hu2117	heart contraction process quality, abnormal whole organism decreased life span, abnormal
Novodvorsky et al., 2015	Fig. 6		vhlhu2117/hu2117; y1Tg	dorsal longitudinal anastomotic vessel increased size, abnormal dorsal longitudinal anastomotic vessel morphology, abnormal intersegmental vessel increased size, abnormal
van Rooijen et al., 2010	Fig. 1		vhlhu2081/+; vhlhu2117/+	regulation of vascular endothelial growth factor receptor signaling pathway process quality, abnormal
	Fig. 2		vhlhu2081/+; vhlhu2117/+; s843Tg	angiogenesis increased occurrence, abnormal blood vessel increased diameter, abnormal cranial blood vessel increased amount, abnormal intersegmental vessel branched, abnormal sprouting angiogenesis increased occurrence, abnormal trunk vasculature blood vessel increased amount, abnormal
	Fig. 3		vhlhu2081/+; vhlhu2117/+ ,   vhlhu2081/+; vhlhu2117/+; s843Tg	angiogenesis increased occurrence, abnormal hyaloid vessel branched, abnormal hyaloid vessel malformed, abnormal ocular blood vessel branched, abnormal ocular blood vessel malformed, abnormal optic choroid vascular plexus branched, abnormal optic choroid vascular plexus malformed, abnormal retina deformed, abnormal retina edematous, abnormal retinal inner plexiform layer ocular blood vessel mislocalised, abnormal
	Fig. 4		vhlhu2081/+; vhlhu2117/+; s843Tg	optic artery increased permeability, abnormal
	Fig. S1		vhlhu2081/+; vhlhu2117/+	pronephric podocyte physical object quality, abnormal
van Rooijen et al., 2009	Fig. 2		vhlhu2081/+; vhlhu2117/+ ,   vhlhu2081/+; vhlhu2117/+; twu34Tg	heart contraction increased rate, abnormal heart increased size, abnormal
	Fig. 3		vhlhu2081/+; vhlhu2117/+ ,   vhlhu2081/+; vhlhu2117/+; la2Tg	hematopoietic stem cell increased amount, abnormal nucleate erythrocyte increased amount, abnormal
	Fig. 5		vhlhu2081/+; vhlhu2117/+	nucleate erythrocyte increased amount, abnormal nucleate erythrocyte optical quality, abnormal
	Fig. S3		vhlhu2081/+; vhlhu2117/+	macrophage increased amount, abnormal