ZFIN

Phenotype Figure Summary

Marker:	ttn.2
Conditions:	Standard or Control

Publication	Data	Fish	Anatomy
Hall et al., 2020	Fig. 4	ttn.2^{uq21rp/uq21rp}; uq22rpTg	skeletal muscle actin filament unstructured, abnormal skeletal muscle myosin filament unstructured, abnormal skeletal muscle T-tubule decreased diameter, abnormal skeletal muscle T-tubule disorganized, abnormal
Ahlberg et al., 2018	Fig. 2	ttn.2^sfc9/+	atrium I band absent, abnormal atrium sarcomere disorganized, abnormal atrium Z disc blurry, abnormal cardiac ventricle I band absent, abnormal cardiac ventricle M band absent, abnormal cardiac ventricle Z disc increased thickness, abnormal
	Fig. 3	ttn.2^sfc9/+	atrium morphology, abnormal cardiac conduction irregular rhythm, abnormal heart functionality, abnormal
	Fig. S11	ttn.2^sfc9/sfc9	atrium ab1-actn labeling spatial pattern, abnormal atrium sarcomere morphology, abnormal atrium Z disc blurry, abnormal
	Fig. S12	ttn.2^sfc9/+	atrium sarcomere disorganized, abnormal atrium Z disc blurry, abnormal cardiac ventricle I band absent, abnormal
	Fig. S13	ttn.2^sfc9/+	atrium sarcomere decreased length, abnormal atrium sarcomere increased width, abnormal cardiac ventricle sarcomere decreased length, abnormal cardiac ventricle sarcomere increased width, abnormal
	Table 5	ttn.2^sfc9/+	heart functionality, abnormal
Ata et al., 2018	Fig. 5	WT + CRISPR13-ttn.2	heart edematous, abnormal
Huttner et al., 2018	Fig. 2	ttn.2^vcc14/vcc14	atrium heart contraction decreased process quality, abnormal blood circulation decreased occurrence, abnormal cardiac ventricle heart contraction decreased process quality, abnormal heart edematous, abnormal myocardium cytosol ab1-myom labeling increased distribution, abnormal myocardium cytosol ab1-myom labeling mislocalised, abnormal myocardium sarcomere organization decreased process quality, abnormal myocardium Z disc disorganized, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. 3	ttn.2^vcc14/+	female organism atrium increased area, abnormal female organism decreased weight, abnormal female organism heart contraction decreased process quality, abnormal male organism heart contraction decreased process quality, abnormal
	Fig. 4	ttn.2^vcc14/+	atrial myocardium has fewer parts of type atrial myocardium sarcomere, abnormal ventricular myocardium has fewer parts of type ventricular myocardium sarcomere, abnormal
	Fig. 5	ttn.2^vcc14/+	cardiac ventricle heart contraction decreased occurrence, abnormal heart nppa expression decreased amount, abnormal
Shih et al., 2016	Fig. 1	ttn.2^xu064/xu064 , ttn.2^xu065/xu065	whole organism ttn.1 expression decreased amount, abnormal whole organism ttn.2 expression decreased amount, abnormal
	Fig. 2	ttn.2^xu068/xu068 , ttn.2^xu065/xu065	somite myofibril disorganized, abnormal somite sarcomere ab1-actn labeling spatial pattern, abnormal somite sarcomere decreased length, abnormal somite sarcomere disorganized, abnormal somite Z disc ab1-actn labeling spatial pattern, abnormal somite Z disc disorganized, abnormal
	Fig. 4	ttn.2^xu065/xu065	somite sarcomere ab1-actn labeling spatial pattern, abnormal somite sarcomere disorganized, abnormal somite Z disc ab1-actn labeling spatial pattern, abnormal somite Z disc disorganized, abnormal
	Fig. 5	ttn.2^xu065/xu065	whole organism ttn.2 expression decreased amount, abnormal
	Fig. 8	ttn.2^xu064/xu064	slow muscle cell myofibril damaged, abnormal
	Fig. S1	ttn.2^xu064/xu064 , ttn.2^xu065/xu065	cardiac ventricle decreased size, abnormal heart contraction decreased rate, abnormal heart contraction process quality, abnormal heart edematous, abnormal muscle structure, abnormal whole organism decreased life span, abnormal whole organism edematous, abnormal
Zou et al., 2015	Fig. 2	ttn.2^sfc9/sfc9 (EKW) , ttn.2^sfc10/sfc10 (EKW) , ttn.2^sfc8/sfc8 (EKW) , ttn.2^sfc13/sfc13 (EKW) , ttn.2^sfc12/sfc12 (EKW) , ttn.2^sfc11/sfc11 (EKW)	cardiac muscle sarcomere disorganized, abnormal skeletal muscle sarcomere disorganized, abnormal
	Fig. 3	ttn.2^sfc11/sfc11 + MO4-tp53 + MO5-ttn.2 (EKW)	skeletal muscle sarcomere disorganized, abnormal
	Fig. 4	EKW + CRISPR10-ttn.2 , ttn.2^sfc10/sfc10 + MO4-ttn.2 (EKW)	skeletal muscle sarcomere disorganized, abnormal
	text only	ttn.2^sfc9/sfc9 (EKW) , ttn.2^sfc10/sfc10 (EKW) , ttn.2^sfc8/sfc8 (EKW) , ttn.2^sfc13/sfc13 (EKW) , ttn.2^sfc12/sfc12 (EKW) , ttn.2^sfc11/sfc11 (EKW)	heart contraction decreased process quality, abnormal locomotion decreased occurrence, abnormal whole organism decreased life span, abnormal
Hansen et al., 2014	Fig. S4	ttn.2^m171/m171	eye decreased size, abnormal
Myhre et al., 2014	Fig. 2	ttn.2^m171/m171	eye decreased size, abnormal head decreased size, abnormal heart contraction decreased process quality, abnormal pericardium edematous, abnormal
Kettleborough et al., 2013	Fig. 4	ttn.2^sa787/sa787 (TL) , ttn.2^sa2492/+; ttn.2^sa787/+ (TL)	growth decreased occurrence, abnormal pericardium edematous, abnormal whole organism paralysed, abnormal
Busch-Nentwich et al., 2012	Fig. 1	ttn.2^sa787/sa787 (TL)	eye decreased size, abnormal head decreased size, abnormal larval locomotory behavior absent, abnormal skeletal muscle quality, abnormal
Paulus et al., 2009	Fig. 1	ttn.2^uw3/uw3 (AB)	myofibril assembly disrupted, abnormal pericardium edematous, abnormal sarcomere organization disrupted, abnormal skeletal muscle tissue development disrupted, abnormal somite grey, abnormal visceral muscle development disrupted, abnormal
	Fig. 2	ttn.2^uw3/uw3 (AB)	axon guidance disrupted, abnormal Rohon-Beard neuron morphology, abnormal sensory neuron mislocalised, abnormal
	Fig. 5	ttn.2^uw3/uw3 (AB)	axon guidance disrupted, abnormal peripheral nervous system neuron axonogenesis increased rate, abnormal Rohon-Beard neuron morphology, abnormal sensory neuron morphology, abnormal
	text only	ttn.2^uw3/uw3 (AB)	muscle contraction disrupted, abnormal
Seeley et al., 2007	Fig. 4	WT + MO2-ttn.2 , ttn.2^m171/m171 (AB) , WT + MO1-ttn.2	cardiac muscle cell decreased contractility, abnormal heart contraction amplitude, abnormal heart decreased contractility, abnormal heart edematous, abnormal
	Fig. 5	WT + MO2-ttn.2 , ttn.2^m171/m171 (AB) , WT + MO1-ttn.2	cardiac muscle cell A band disorganized, abnormal cardiac muscle cell Z disc disorganized, abnormal cardiac myofibril assembly disrupted, abnormal
	Fig. 6	WT + MO2-ttn.2	skeletal muscle cell A band disorganized, abnormal skeletal muscle cell Z disc disorganized, abnormal skeletal myofibril assembly disrupted, abnormal
	text only	WT + MO2-ttn.2	larval locomotory behavior disrupted, abnormal whole organism decreased behavioural activity, abnormal
Phenotype Annotation (1994-2006)	Fig. for (m171)	ttn.2^m171/m171 (AB)	heart quality, abnormal
	Fig. for (m186)	ttn.2^m186 (AB)	heart quality, abnormal
	Fig. for (m242)	ttn.2^m242 (AB)	heart quality, abnormal
	Fig. for (m740)	ttn.2^m740 (AB)	heart quality, abnormal
Xu et al., 2002	Fig. 4	ttn.2^m171/m171 (AB)	cardiac muscle cell myofibril decreased amount, abnormal cardiac muscle cell myofibril decreased size, abnormal cardiac muscle cell myofibril disorganized, abnormal ventricular cardiac myofibril assembly disrupted, abnormal
	text only	ttn.2^m171/m171 (AB)	cardiac muscle cell decreased thickness, abnormal heart contraction process quality, abnormal heart decreased contractility, abnormal heart dilated, abnormal regulation of blood pressure disrupted, abnormal
Stainier et al., 1996	Table 2	ttn.2^m186/m186 (AB) , ttn.2^m242/m242 , ttn.2^m171/m171 (AB) , ttn.2^m740/m740 (AB)	atrium contractility, abnormal cardiac ventricle contractility, abnormal heart contraction disrupted, abnormal heart decreased strength, abnormal