Genomic Feature

fh332

ID
ZDB-ALT-101008-17
Name
fh332
Synonyms
None
Affected Genomic Region
Construct
None
Type
Allele with one point mutation
Protocol
adult males treated with ENU
Lab of Origin
Moens Lab
Current Source
China Zebrafish Resource Center (CZRC)    (order this)
Zebrafish International Resource Center (ZIRC)    (order this)
Other Pages
Note
notch3 fh332 harbors a nonsense mutation that introduces a premature stop codon at amino acid position 669 within the 8th Notch3 EGF repeat. The mutation is expected to generate a non-functional truncated protein lacking most of the extracellular and all of the transmembrane and intracellular domains of Notch3. fh332/fh332 homozygous embryos and larvae developed at normal speed and without apparent morphological defects, although the mutation was lethal before adulthood.
notch3 fh332 harbors a nonsense mutation that introduces a premature stop codon at amino acid position 669 within the 8th Notch3 EGF repeat. The mutation is expected to generate a non-functional truncated protein lacking most of the extracellular and all of the transmembrane and intracellular domains of Notch3. fh332/fh332 homozygous embryos and larvae developed at normal speed and without apparent morphological defects, although the mutation was lethal before adulthood.
Genome Browser
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Variants
Variant Type
Point Mutation
Variant Location
Chr: 3 Details
Nucleotide change
Variant Notes
notch3 fh332 harbors a nonsense mutation that introduces a premature stop codon  ...
Effect on DNA/cDNA, transcript, protein (from publications)
DNA/cDNA Change
None
Transcript Consequence
Premature Stop (1)
Protein Consequence
Polypeptide Truncation: at position 669 (1)
Sequences
Flanking Sequence
None
Additional Sequence
None
Fish
Supplemental Information
Genotyping protocol
None
Citations