TALEN

TALEN1-csf1rb

ID

ZDB-TALEN-180813-1

Name

TALEN1-csf1rb

Previous Names

None

Target

csf1rb (1)

Target Sequence 1

5' - ACCAAACCTTCAGCCGA - 3'

Target Sequence 2

5' - CATGTTCACCGTACAGAC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
re01	csf1rb

Expression

Gene expression in Wild Types + TALEN1-csf1rb

No data available

Phenotype

Phenotype resulting from TALEN1-csf1rb

No data available

Phenotype of all Fish created by or utilizing TALEN1-csf1rb

Phenotype	Fish	Conditions	Figures
optic tectum ventral region has fewer parts of type microglial cell, abnormal	csf1rb^re01/re01	control	Fig. 2 from Oosterhof et al., 2018
optic tectum dorso-lateral region has fewer parts of type microglial cell, abnormal	csf1rb^re01/re01	control	Fig. 2 from Oosterhof et al., 2018
microglial cell decreased amount, abnormal	csf1rb^re01/re01	control	Fig. 1 from Oosterhof et al., 2018
microglial cell decreased amount, abnormal	csf1rb^re01/re01; gl22Tg; s898Tg; sd5Tg	standard conditions	Fig. 4 from Ferrero et al., 2020
caudal hematopoietic tissue macrophage decreased amount, abnormal	csf1rb^re01/re01; gl22Tg; s898Tg; sd5Tg	standard conditions	Fig. 6 from Ferrero et al., 2020
microglial cell decreased mass density, abnormal	csf1rb^re01/re01; gl22Tg; s898Tg; sd5Tg	standard conditions	Fig. 4 from Ferrero et al., 2020
macrophage decreased amount, abnormal	csf1rb^re01/re01; gl22Tg; sd5Tg	standard conditions	Fig. 5 from Ferrero et al., 2020
midbrain microglial cell decreased amount, abnormal	csf1ra^j4e1/+; csf1ra^re25/+; csf1rb^re01/re01	standard conditions	Fig. 3 from Berdowski et al., 2022
midbrain microglial cell decreased amount, abnormal	csf1ra^j4e1/+; csf1rb^re01/re01	standard conditions	Fig. 2 , Fig. 3 from Berdowski et al., 2022
midbrain inclusion body increased amount, abnormal	csf1ra^j4e1/+; csf1rb^re01/re01	standard conditions	Fig. 7 from Berdowski et al., 2022
midbrain microglial cell decreased amount, abnormal	csf1ra^j4e1/+; csf1rb^re01/re01; gl22Tg	standard conditions	Fig. 2 from Berdowski et al., 2022
midbrain inclusion body increased amount, abnormal	csf1ra^j4e1/+; csf1rb^re01/re01; re10Tg	standard conditions	Fig. 7 from Berdowski et al., 2022
hindbrain oligodendrocyte decreased amount, abnormal	csf1ra^j4e1/+; csf1rb^re01/re01; vu234Tg	standard conditions	Fig. 4 from Berdowski et al., 2022
optic tectum microglial cell decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/+	control	Fig. 1 from Oosterhof et al., 2018
optic tectum ventral region has extra parts of type microglial cell, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/+	control	Fig. 2 from Oosterhof et al., 2018
optic tectum dorso-lateral region has fewer parts of type microglial cell, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/+	control	Fig. 2 from Oosterhof et al., 2018
brain microglial cell decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/+	control	Fig. 2 from Oosterhof et al., 2018
whole organism mpeg1.1 expression decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 3 from Berdowski et al., 2022
midbrain microglial cell decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 2 from Berdowski et al., 2022
whole organism swimming behavior decreased process quality, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Berdowski et al., 2022
regenerating tissue macrophage increased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	transection: spinal cord	Fig. 3 from Tsarouchas et al., 2018
optic tectum dorso-lateral region lacks all parts of type microglial cell, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	control	Fig. 2 from Oosterhof et al., 2018
optic tectum microglial cell decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	control	Fig. 1 from Oosterhof et al., 2018
midbrain inclusion body increased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 7 from Berdowski et al., 2022
microglial cell apoeb expression decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 3 from Ferrero et al., 2020
brain cux1a expression decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Oosterhof et al., 2019
regenerating tissue microglial cell absent, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	transection: spinal cord	Fig. 3 from Tsarouchas et al., 2018
brain lacks all parts of type microglial cell, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Oosterhof et al., 2019
optic tectum microglial cell ab2-lcp1 labeling absent, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	control	Fig. 2 from Oosterhof et al., 2018
microglial cell absent, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	control	Fig. 1 from Oosterhof et al., 2018
regenerating tissue microglial cell ab-4c4 labeling absent, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	transection: spinal cord	Fig. 3 from Tsarouchas et al., 2018
whole organism csf1ra expression decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 3 from Berdowski et al., 2022
hindbrain oligodendrocyte plp1b expression decreased distribution, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Berdowski et al., 2022
regenerating tissue neutrophil decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	transection: spinal cord	Fig. 3 from Tsarouchas et al., 2018
brain microglial cell ab2-lcp1 labeling absent, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	control	Fig. 2 from Oosterhof et al., 2018
brain microglial cell decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	control	Fig. 2 from Oosterhof et al., 2018
optic tectum ventral region lacks all parts of type microglial cell, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	control	Fig. 2 from Oosterhof et al., 2018
hemal arch decreased size, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Oosterhof et al., 2019
brain lacks parts or has fewer parts of type microglial cell, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Oosterhof et al., 2019
hindbrain oligodendrocyte mbpa expression decreased distribution, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Berdowski et al., 2022
microglial cell decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	control	Fig. 3 from Ferrero et al., 2020 Fig. 1 from Oosterhof et al., 2018
neural arch decreased size, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Oosterhof et al., 2019
brain microglia differentiation disrupted, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01	standard conditions	Fig. 4 from Oosterhof et al., 2019
microglial cell decreased mass density, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01; gl22Tg; s898Tg; sd5Tg	standard conditions	Fig. 4 from Ferrero et al., 2020
radial glial cell lysosome increased size, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01; re10Tg	standard conditions	Fig. 3 from Kuil et al., 2019
midbrain inclusion body increased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01; re10Tg	standard conditions	Fig. 7 from Berdowski et al., 2022
hindbrain myelin sheath decreased area, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01; ue2Tg	standard conditions	Fig. 4 from Berdowski et al., 2022
hindbrain myelin sheath EGFP expression decreased distribution, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01; ue2Tg	standard conditions	Fig. 4 from Berdowski et al., 2022
hindbrain oligodendrocyte decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/re01; vu234Tg	standard conditions	Fig. 4 from Berdowski et al., 2022
midbrain microglial cell decreased amount, abnormal	csf1ra^re25/+; csf1ra^re26/+; csf1rb^re01/re01	standard conditions	Fig. 3 from Berdowski et al., 2022
midbrain microglial cell decreased amount, abnormal	csf1ra^re25/+; csf1rb^re01/re01	standard conditions	Fig. 2 , Fig. 3 from Berdowski et al., 2022
midbrain microglial cell decreased amount, abnormal	csf1ra^re25/+; csf1rb^re01/re01; gl22Tg	standard conditions	Fig. 2 from Berdowski et al., 2022
whole organism mpeg1.1 expression decreased amount, abnormal	csf1ra^re25/re25; csf1rb^re01/re01	standard conditions	Fig. 3 from Berdowski et al., 2022
midbrain microglial cell decreased amount, abnormal	csf1ra^re25/re25; csf1rb^re01/re01	standard conditions	Fig. 2 from Berdowski et al., 2022
whole organism csf1ra expression decreased amount, abnormal	csf1ra^re25/re25; csf1rb^re01/re01	standard conditions	Fig. 3 from Berdowski et al., 2022
whole organism mpeg1.1 expression decreased amount, abnormal	csf1ra^re26/re26; csf1rb^re01/re01	standard conditions	Fig. 3 from Berdowski et al., 2022
whole organism csf1ra expression decreased amount, abnormal	csf1ra^re26/re26; csf1rb^re01/re01	standard conditions	Fig. 3 from Berdowski et al., 2022
microglial cell cell population proliferation delayed, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/+; c264Tg; gl22Tg; zf279Et	chemical ablation: neuron, chemical treatment by environment: metronidazole	Fig. 6 from Oosterhof et al., 2018
microglial cell decreased amount, abnormal	csf1ra^j4e1/j4e1; csf1rb^re01/+; c264Tg; gl22Tg; zf279Et	control	Fig. 6 from Oosterhof et al., 2018

Citations