TALEN

TALEN1-ttn.2

ID

ZDB-TALEN-170215-1

Name

TALEN1-ttn.2

Previous Names

None

Target

ttn.2 (1)

Target Sequence 1

5' - AAAACTATAATTTCAG - 3'

Target Sequence 2

5' - TCCACCCGAGTCTGACGAG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 9

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
xu064	ttn.2
xu068	ttn.2
xu069a	ttn.1
xu069b	ttn.2

Expression

Gene expression in Wild Types + TALEN1-ttn.2

No data available

Phenotype

Phenotype resulting from TALEN1-ttn.2

No data available

Phenotype of all Fish created by or utilizing TALEN1-ttn.2

Phenotype	Fish	Conditions	Figures
somite Z disc disorganized, abnormal	ttn.1^{xu069a/xu069a}	standard conditions	Fig. 4 from Shih et al., 2016
somite Z disc ab1-actn labeling spatial pattern, abnormal	ttn.1^{xu069a/xu069a}	standard conditions	Fig. 4 from Shih et al., 2016
somite sarcomere disorganized, abnormal	ttn.1^{xu069a/xu069a}	standard conditions	Fig. 4 from Shih et al., 2016
somite sarcomere ab1-actn labeling spatial pattern, abnormal	ttn.1^{xu069a/xu069a}	standard conditions	Fig. 4 from Shih et al., 2016
whole organism ttn.1 expression decreased amount, abnormal	ttn.1^{xu069a/xu069a}	standard conditions	Fig. 4 from Shih et al., 2016
heart edematous, abnormal	ttn.2^xu064/xu064	standard conditions	Fig. S1 from Shih et al., 2016
slow muscle cell myofibril structure, ameliorated	ttn.2^xu064/xu064	chemical treatment by environment: tricaine	Fig. 8 from Shih et al., 2016
heart contraction process quality, abnormal	ttn.2^xu064/xu064	standard conditions	Fig. S1 from Shih et al., 2016
whole organism decreased life span, abnormal	ttn.2^xu064/xu064	standard conditions	Fig. S1 from Shih et al., 2016
heart contraction decreased rate, abnormal	ttn.2^xu064/xu064	standard conditions	Fig. S1 from Shih et al., 2016
whole organism ttn.2 expression decreased amount, abnormal	ttn.2^xu064/xu064	standard conditions	Fig. 1 from Shih et al., 2016
slow muscle cell myofibril damaged, abnormal	ttn.2^xu064/xu064	control	Fig. 8 from Shih et al., 2016
whole organism ttn.1 expression decreased amount, abnormal	ttn.2^xu064/xu064	standard conditions	Fig. 1 from Shih et al., 2016
slow muscle cell myofibril damaged, exacerbated	ttn.2^xu064/xu064	chemical treatment by environment: bleaching agent	Fig. 8 from Shih et al., 2016
cardiac ventricle decreased size, abnormal	ttn.2^xu064/xu064	standard conditions	Fig. S1 from Shih et al., 2016
whole organism edematous, abnormal	ttn.2^xu064/xu064	standard conditions	Fig. S1 from Shih et al., 2016
somite sarcomere decreased length, abnormal	ttn.2^xu068/xu068	standard conditions	Fig. 2 from Shih et al., 2016
somite Z disc disorganized, abnormal	ttn.2^xu068/xu068	standard conditions	Fig. 2 from Shih et al., 2016
somite Z disc ab1-actn labeling spatial pattern, abnormal	ttn.2^xu068/xu068	standard conditions	Fig. 2 from Shih et al., 2016
somite myofibril disorganized, abnormal	ttn.2^xu068/xu068	standard conditions	Fig. 2 from Shih et al., 2016
somite sarcomere disorganized, abnormal	ttn.2^xu068/xu068	standard conditions	Fig. 2 from Shih et al., 2016
somite sarcomere ab1-actn labeling spatial pattern, abnormal	ttn.2^xu068/xu068	standard conditions	Fig. 2 from Shih et al., 2016

Citations

Include unpublished citations

Shih, Y.H., Dvornikov, A.V., Zhu, P., Ma, X., Kim, M.J., Ding, Y., Xu, X. (2016) Exon- and contraction-dependent functions of titin in sarcomere assembly. Development (Cambridge, England). 143(24):4713-4722

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