PUBLICATION
Mutations affecting development of the notochord in zebrafish
- Authors
- Stemple, D.L., Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S.C., Schier, A.F., Malicki, J., Stainier, D.Y., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E., and Driever, W.
- ID
- ZDB-PUB-970210-10
- Date
- 1996
- Source
- Development (Cambridge, England) 123: 117-128 (Journal)
- Registered Authors
- Abdelilah-Seyfried, Salim, Driever, Wolfgang, Malicki, Jarema, Mountcastle-Shah, Elizabeth, Neuhauss, Stephan, Schier, Alexander, Solnica-Krezel, Lilianna, Stainier, Didier, Stemple, Derek L.
- Keywords
- zebrafish; notochord; floor plate; mesoderm; embryogenesis
- MeSH Terms
-
- Brain/embryology
- Mesoderm/physiology
- Mutation*
- Zebrafish/embryology*
- Zebrafish/genetics*
- Phenotype
- Cell Differentiation/genetics
- Gene Expression Regulation, Developmental*
- Animals
- Notochord/anatomy & histology
- Notochord/cytology
- Notochord/embryology*
- PubMed
- 9007234 Full text @ Development
Citation
Stemple, D.L., Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S.C., Schier, A.F., Malicki, J., Stainier, D.Y., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E., and Driever, W. (1996) Mutations affecting development of the notochord in zebrafish. Development (Cambridge, England). 123:117-128.
Abstract
The notochord is critical for the normal development of vertebrate embryos. It serves both as the major skeletal element of the embryo and as a signaling source for the establishment of pattern within the neurectoderm, the paraxial mesoderm and other tissues. In a large-scale systematic screen of mutations affecting embryogenesis in zebrafish we identified 65 mutations that fall into 29 complementation groups, each leading to a defect in the formation and/or maintenance of the notochord. These mutations produce phenotypic abnormalities at numerous stages of notochord development, thereby establishing a phenotypic pathway, which in turn suggests a genetic pathway for the development of the notochord. Perturbations within adjacent tissues in mutant embryos further indicate the importance of notochord-derived signals for patterning within the embryo and suggest that these mutations will yield additional insight into the cues that regulate these patterning processes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping