ZFIN ID: ZDB-PERS-960805-14
Abdelilah-Seyfried, Salim
Email: salim@mdc-berlin.de
URL: http://www.mdc-berlin.de/cellpolarity/
Affiliation: Abdelilah-Seyfried Lab Hannover
and also: Abdelilah-Seyfried Lab Potsdam
Address: Max Delbrück Center for Molecular Medicine Berlin-Buch Robert-Rössle-Strasse 10 Berlin , D-13125 Germany
Country: Germany
Phone: Office: 49-30-9406-2337, Lab: 49-30-9406-2517
Fax: 49-30-9406-2110


Yang, Z., Wu, S., Fontana, F., Li, Y., Xiao, W., Gao, Z., Stephan, A., Affolter, M., Belting, H.G., Abdelilah-Seyfried, S., Zhang, J. (2020) The tight junctions protein Claudin-5 limits endothelial cell motility. Journal of Cell Science. 134(1):
Flinn, M.A., Otten, C., Brandt, Z.J., Bostrom, J.R., Kenarsary, A., Wan, T.C., Auchampach, J.A., Abdelilah-Seyfried, S., O'Meara, C.C., Link, B.A. (2020) Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development (Cambridge, England). 147(16):
Fontana, F., Haack, T., Reichenbach, M., Knaus, P., Puceat, M., Abdelilah-Seyfried, S. (2020) Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling during Zebrafish Cardiac Valvulogenesis. Cell Reports. 32:107883
Sanchez-Lopez, C., Labadie, N., Lombardo, V., Biglione, F., Manta, B., Jacob, R., Gladyshev, V., Abdelilah-Seyfried, S., Selenko, P., Binolfi, A. (2020) An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo. Chemistry (Weinheim an der Bergstrasse, Germany). 26(65):14838-14843
Cardoso, C., Arnould, M., De Luca, C., Otten, C., Abdelilah-Seyfried, S., Heredia, A., Leutenegger, A.L., Schwaninger, M., Tournier-Lasserve, E., Boulday, G. (2020) Novel Chronic Mouse Model of Cerebral Cavernous Malformations. Stroke. 51(4):1272-1278
Donat, S., Abdelilah-Seyfried, S. (2020) Generation of Transgenic Lines of Zebrafish Expressing Fluorescently Tagged CCM Proteins to Study Their Function and Subcellular Localization Within the Vasculature. Methods in molecular biology (Clifton, N.J.). 2152:207-224
Lombardo, V.A., Heise, M., Moghtadaei, M., Bornhorst, D., Männer, J., Abdelilah-Seyfried, S. (2019) Morphogenetic control of zebrafish cardiac looping by Bmp signaling. Development (Cambridge, England). 146(22):
Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V., Mochizuki, N., Heisenberg, C.P., Yelon, D., Abdelilah-Seyfried, S. (2019) Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature communications. 10:4113
Rödel, C.J., Otten, C., Donat, S., Lourenco, M., Fischer, D., Kuropka, B., Paolini, A., Freund, C., Abdelilah-Seyfried, S. (2019) Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Circulation research. 125(10):e43-e54
Chapman, E.M., Lant, B., Ohashi, Y., Yu, B., Schertzberg, M., Go, C., Dogra, D., Koskimäki, J., Girard, R., Li, Y., Fraser, A.G., Awad, I.A., Abdelilah-Seyfried, S., Gingras, A.C., Derry, W.B. (2019) A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Nature communications. 10:1791
Demal, T.J., Heise, M., Reiz, B., Dogra, D., Brænne, I., Reichenspurner, H., Männer, J., Aherrahrou, Z., Schunkert, H., Erdmann, J., Abdelilah-Seyfried, S. (2019) A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A. Scientific Reports. 9:2959
Otten, C., Knox, J., Boulday, G., Eymery, M., Haniszewski, M., Neuenschwander, M., Radetzki, S., Vogt, I., Hähn, K., De Luca, C., Cardoso, C., Hamad, S., Igual Gil, C., Roy, P., Albiges-Rizo, C., Faurobert, E., von Kries, J.P., Campillos, M., Tournier-Lasserve, E., Derry, W.B., Abdelilah-Seyfried, S. (2018) Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations. EMBO Molecular Medicine. 10(10)
Lisowska, J., Rödel, C.J., Manet, S., Miroshnikova, Y.A., Boyault, C., Planus, E., De Mets, R., Lee, H.H., Destaing, O., Mertani, H., Boulday, G., Tournier-Lasserve, E., Balland, M., Abdelilah-Seyfried, S., Albiges-Rizo, C., Faurobert, E. (2018) Cerebral Cavernous Malformation 1/2 complex controls ROCK1 and ROCK2 complementary functions for endothelial integrity. Journal of Cell Science. 131(15)
Paolini, A., Abdelilah-Seyfried, S. (2018) The mechanobiology of zebrafish cardiac valve leaflet formation. Current opinion in cell biology. 55:52-58
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161
Olmer, R., Engels, L., Usman, A., Menke, S., Malik, M.N.H., Pessler, F., Göhring, G., Bornhorst, D., Bolten, S., Abdelilah-Seyfried, S., Scheper, T., Kempf, H., Zweigerdt, R., Martin, U. (2018) Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture. Stem Cell Reports. 10:1657-1672
Donat, S., Lourenço, M., Paolini, A., Otten, C., Renz, M., Abdelilah-Seyfried, S. (2018) Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis. eLIFE. 7:e28939
Dittmar, F., Abdelilah-Seyfried, S., Tschirner, S.K., Kaever, V., Seifert, R. (2015) Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish. Biochemical and Biophysical Research Communications. 468(4):708-12
Renz, M., Otten, C., Faurobert, E., Rudolph, F., Zhu, Y., Boulday, G., Duchene, J., Mickoleit, M., Dietrich, A.C., Ramspacher, C., Steed, E., Manet-Dupé, S., Benz, A., Hassel, D., Vermot, J., Huisken, J., Tournier-Lasserve, E., Felbor, U., Sure, U., Albiges-Rizo, C., Abdelilah-Seyfried, S. (2015) Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins. Developmental Cell. 32:181-190
Dietrich, A.C., Lombardo, V.A., Abdelilah-Seyfried, S. (2014) Blood Flow and Bmp Signaling Control Endocardial Chamber Morphogenesis. Developmental Cell. 30:367-377
Bennet, M., Akiva, A., Faivre, D., Malkinson, G., Yaniv, K., Abdelilah-Seyfried, S., Fratzl, P., Masic, A. (2014) Simultaneous Raman microspectroscopy and fluorescence imaging of bone mineralization in living zebrafish larvae. Biophysical journal. 106:L17-9
Wieffer, M., Cibrián Uhalte, E., Posor, Y., Otten, C., Branz, K., Schütz, I., Mössinger, J., Schu, P., Abdelilah-Seyfried, S., Krauß, M., and Haucke, V. (2013) PI4K2beta/AP-1-Based TGN-Endosomal Sorting Regulates Wnt Signaling. Current biology : CB. 23(21):2185-2190
Tay, H.G., Schulze, S.K., Compagnon, J., Foley, F.C., Heisenberg, C.P., Yost, H.J., Abdelilah-Seyfried, S., and Amack, J.D. (2013) Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle. Development (Cambridge, England). 140(7):1550-1559
Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L., and Abdelilah-Seyfried, S. (2013) Unilateral dampening of bmp activity by nodal generates cardiac left-right asymmetry. Developmental Cell. 24(6):660-667
Otten, C., and Abdelilah-Seyfried, S. (2013) Laser-inflicted Injury of Zebrafish Embryonic Skeletal Muscle. Journal of visualized experiments : JoVE. (71):e4351
Lombardo, V.A., Sporbert, A., and Abdelilah-Seyfried, S. (2012) Cell tracking using photoconvertible proteins during zebrafish development. Journal of visualized experiments : JoVE. (67)
Zhang, J., Liss, M., Wolburg, H., Blasig, I.E., and Abdelilah-Seyfried, S. (2012) Involvement of claudins in zebrafish brain ventricle morphogenesis. Annals of the New York Academy of Sciences. 1257(1):193-198
de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., Strate, I., Smith, K., Lagendijk, A.K., Schilling, T.F., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M., and Bakkers, J. (2012) Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation. Circulation research. 110(4):578-587
Cibrián Uhalte, E., Kirchner, M., Hellwig, N., Allen, J.J., Donat, S., Shokat, K.M., Selbach, M., and Abdelilah-Seyfried, S. (2012) In vivo conditions to identify prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish. PLoS One. 7(6):e40000
Otten, C., van der Ven, P.F., Lewrenz, I., Paul, S., Steinhagen, A., Busch-Nentwich, E., Eichhorst, J., Wiesner, B., Stemple, D., Strähle, U., Fürst, D.O., and Abdelilah-Seyfried, S. (2012) Xirp proteins mark injured skeletal muscle in zebrafish. PLoS One. 7(2):e31041
Ghani, S., Riemke, P., Schönheit, J., Lenze, D., Stumm, J., Hoogenkamp, M., Lagendijk, A., Heinz, S., Bonifer, C., Bakkers, J., Abdelilah-Seyfried, S., Hummel, M., and Rosenbauer, F. (2011) Macrophage development from hematopoietic stem cells requires PU.1 coordinated microRNA expression. Blood. 118(8):2275-84
Kur, E., Christa, A., Veth, K.N., Gajera, C.R., Andrade-Navarro, M.A., Zhang, J., Willer, J.R., Gregg, R.G., Abdelilah-Seyfried, S., Bachmann, S., Link, B.A., Hammes, A., and Willnow, T.E. (2011) Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(6):1567-1577
Klein, C., Mikutta, J., Krueger, J., Scholz, K., Brinkmann, J., Liu, D., Veerkamp, J., Siegel, D., Abdelilah-Seyfried, S., and le Noble, F. (2011) Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis. Development (Cambridge, England). 138(10):1935-1945
Abdelilah-Seyfried, S. (2010) Claudin-5a in developing zebrafish brain barriers: another brick in the wall. BioEssays : news and reviews in molecular, cellular and developmental biology. 32(9):768-776
Zhang, J., Piontek, J., Wolburg, H., Piehl, C., Liss, M., Otten, C., Christ, A., Willnow, T.E., Blasig, I.E., and Abdelilah-Seyfried, S. (2010) Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proceedings of the National Academy of Sciences of the United States of America. 107(4):1425-1430
Seipold, S., Priller, F.C., Goldsmith, P., Harris, W.A., Baier, H., and Abdelilah-Seyfried, S. (2009) Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina. BMC Developmental Biology. 9:40
Nyholm, M.K., Abdelilah-Seyfried, S., and Grinblat, Y. (2009) A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation. Journal of Cell Science. 122(Pt 12):2137-2148
Bakkers, J., Verhoeven, M.C., and Abdelilah-Seyfried, S. (2009) Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis. Developmental Biology. 330(2):213-220
Hava, D., Forster, U., Matsuda, M., Cui, S., Link, B.A., Eichhorst, J., Wiesner, B., Chitnis, A., and Abdelilah-Seyfried, S. (2009) Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. Journal of Cell Science. 122(Pt 5):687-695
Munson, C., Huisken, J., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober, E.A., Verkade, H., Abdelilah-Seyfried, S., and Stainier, D.Y. (2008) Regulation of neurocoel morphogenesis by Pard6gammab. Developmental Biology. 324(1):41-54
Lange, M., Kaynak, B., Forster, U.B., Tönjes, M., Fischer, J.J., Grimm, C., Schlesinger, J., Just, S., Dunkel, I., Krueger, T., Mebus, S., Lehrach, H., Lurz, R., Gobom, J., Rottbauer, W., Abdelilah-Seyfried, S., and Sperling, S. (2008) Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes & Development. 22(17):2370-2384
Bit-Avragim, N., Hellwig, N., Rudolph, F., Munson, C., Stainier, D.Y., and Abdelilah-Seyfried, S. (2008) Divergent polarization mechanisms during vertebrate epithelial development mediated by the Crumbs complex protein Nagie oko. Journal of Cell Science. 121(Pt 15):2503-2510
Rohr, S., Otten, C., and Abdelilah-Seyfried, S. (2008) Asymmetric involution of the myocardial field drives heart tube formation in zebrafish. Circulation research. 102(2):e12-19
Bit-Avragim, N., Rohr, S., Rudolph, F., Van Der Ven, P., Fürst, D., Eichhorst, J., Wiesner, B., and Abdelilah-Seyfried, S. (2008) Nuclear localization of the zebrafish tight junction protein nagie oko. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(1):83-90
Cui, S., Otten, C., Rohr, S., Abdelilah-Seyfried, S., and Link, B.A. (2007) Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. Molecular and cellular neurosciences. 34(3):431-444
Cibrian-Uhalte, E., Langenbacher, A., Shu, X., Chen, J.N., and Abdelilah-Seyfried, S. (2007) Involvement of zebrafish Na+,K+ ATPase in myocardial cell junction maintenance. The Journal of cell biology. 176(2):223-230
Anzenberger, U., Bit-Avragim, N., Rohr, S., Rudolph, F., Dehmel, B., Willnow, T.E., and Abdelilah-Seyfried, S. (2006) Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. Journal of Cell Science. 119(10):2127-2137
Rohr, S., Bit-Avragim, N., and Abdelilah-Seyfried, S. (2006) Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis. Development (Cambridge, England). 133(1):107-115
Hauptmann, G., Belting, H.-G., Wolke, U., Lunde, K., Söll, I., Abdelilah-Seyfried, S., Prince, V., and Driever, W. (2002) spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development (Cambridge, England). 129(7):1645-1655
Belting, H.G., Hauptmann, G., Meyer, D., Abdelilah-Seyfried, S., Chitnis, A., Eschbach, C., Söll, I., Thisse, C., Thisse, B., Artinger, K., Lunde, K., and Driever, W. (2001) spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer. Development (Cambridge, England). 128(21):4165-4176
Horne-Badovinac, S., Lin, D., Waldron, S., Schwarz, M, Mbamalu, G., Pawson, T., Jan, Y.-N., Stainier, D.Y.R., and Abdelilah-Seyfried, S. (2001) Positional cloning of heart and soul reveals multiple roles for PKCl in zebrafish organogenesis. Current biology : CB. 11(19):1492-1502
Abdelilah, S. and Driever, W. (1997) Pattern formation in janus-mutant zebrafish embryos. Developmental Biology. 184(1):70-84
Driever, W., Solnica-Krezel, L., Abdelilah, S., Meyer, D., and Stemple, D. (1997) Genetic analysis of pattern formation in the zebrafish neural plate. Cold Spring Harbor symposia on quantitative biology. 62:523-534
Stemple, D.L., Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S.C., Schier, A.F., Malicki, J., Stainier, D.Y., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E., and Driever, W. (1996) Mutations affecting development of the notochord in zebrafish. Development (Cambridge, England). 123:117-128
Schier, A.F., Neuhauss, S.C., Harvey, M., Malicki, J., Solnica-Krezel, L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Stemple, D.L., Rangini, Z., Yang, H., and Driever, W. (1996) Mutations affecting the development of the embryonic zebrafish brain. Development (Cambridge, England). 123:165-178
Abdelilah, S., Mountcastle-Shah, E., Harvey, M., Solnica-Krezel, L., Schier, A.F., Stemple, D.L., Malicki, J., Neuhauss, S.C., Zwartkruis, F., Stainier, D.Y., Rangini, Z., and Driever, W. (1996) Mutations affecting neural survival in the zebrafish Danio rerio. Development (Cambridge, England). 123:217-227
Malicki, J., Neuhauss, S.C., Schier, A.F., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Abdelilah, S., Zwartkruis, F., Rangini, Z., and Driever, W. (1996) Mutations affecting development of the zebrafish retina. Development (Cambridge, England). 123:263-273
Malicki, J., Schier, A.F., Solnica-Krezel, L., Stemple, D.L., Neuhauss, S.C., Stainier, D.Y., Abdelilah, S., Rangini, Z., Zwartkruis, F., and Driever, W. (1996) Mutations affecting development of the zebrafish ear. Development (Cambridge, England). 123:275-283
Weinstein, B.M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Driever, W., and Fishman, M.C. (1996) Hematopoietic mutations in the zebrafish. Development (Cambridge, England). 123:303-309
Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Malicki, J., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J., and Boggs, C. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development (Cambridge, England). 123:37-46
Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Abdelilah, S., Stainier, D.Y., and Driever, W. (1996) Mutations affecting craniofacial development in zebrafish. Development (Cambridge, England). 123:357-367
Solnica-Krezel, L., Stemple, D.L., Mountcastle-Shah, E., Rangini, Z., Neuhauss, S.C., Malicki, J., Schier, A.F., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., and Driever, W. (1996) Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development (Cambridge, England). 123:67-80
Abdelilah, S.,Driever, W., Gorn, A., Malicki,J., Neuhauss, S., Pack, M., Rangini, Z., Schier, A., Solnica-Krezel, L., Stanier, D., and Stemple, D. (1996) Anatomy of the 24, 48, 72 and 120 hours Zebrafish (Danio rerio) Embryo. ZFIN Direct Data Submission.
Abdelilah, S., Solnica-Krezel, L., Stainier, D.Y.R., and Driever, W. (1994) Implications for dorsoventral axis determination from the zebrafish mutation janus. Nature. 370:468-471

Cox, D.N., Abdelilah-Seyfried, S., Jan, L.Y. and Jan, Y.N. (2001). Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary. PNAS 98(25):14475-14480.

Abdelilah-Seyfried, S., Chan, Y.M., Zeng, C., Justice, N.J., Younger-Shepherd, S., Sharp, L.E., Barbel, S., Meadows, S.A., Jan, L.Y. and Jan, Y.N. (2000). A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics 155:733-752.

Zeng, C., Justice, N.J., Abdelilah, S., Chan, Y.M., Jan, L.Y. and Jan, Y.N. (1998). The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionary conserved function in appendage development. PNAS 95(18):10637-10642.