PUBLICATION

From local resynchronization to global pattern recovery in the zebrafish segmentation clock

Authors
Uriu, K., Liao, B.K., Oates, A.C., Morelli, L.G.
ID
ZDB-PUB-210216-16
Date
2021
Source
eLIFE   10: (Journal)
Registered Authors
Oates, Andrew
Keywords
developmental biology, physics of living systems, zebrafish
MeSH Terms
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/physiology*
  • Gene Expression Regulation, Developmental
  • Biological Clocks*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Body Patterning
  • Receptors, Notch/genetics
  • Receptors, Notch/metabolism
  • Signal Transduction
  • Animals
(all 12)
PubMed
33587039 Full text @ Elife
Abstract
Integrity of rhythmic spatial gene expression patterns in the vertebrate segmentation clock requires local synchronization between neighboring cells by Delta-Notch signaling and its inhibition causes defective segment boundaries. Whether deformation of the oscillating tissue complements local synchronization during patterning and segment formation is not understood. We combine theory and experiment to investigate this question in the zebrafish segmentation clock. We remove a Notch inhibitor, allowing resynchronization, and analyze embryonic segment recovery. We observe unexpected intermingling of normal and defective segments, and capture this with a new model combining coupled oscillators and tissue mechanics. Intermingled segments are explained in the theory by advection of persistent phase vortices of oscillators. Experimentally observed changes in recovery patterns are predicted in the theory by temporal changes in tissue length and cell advection pattern. Thus, segmental pattern recovery occurs at two length and time scales: rapid local synchronization between neighboring cells, and the slower transport of the resulting patterns across the tissue through morphogenesis.
Genes / Markers
Figures
Figure Gallery (25 images) / 3
Show all Figures
Expression
Phenotype
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
No data available
Mapping
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Citation
Uriu, K., Liao, B.K., Oates, A.C., Morelli, L.G. (2021) From local resynchronization to global pattern recovery in the zebrafish segmentation clock. eLIFE. 10:.