PUBLICATION

Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality

Authors
Concha, M.L., Russell, C., Regan, J.C., Tawk, M., Sidi, S., Gilmour, D.T., Kapsimali, M., Sumoy, L., Goldstone, K., Amaya, E., Kimelman, D., Nicolson, T., Gründer, S., Gomperts, M., Clarke, J.D.W., and Wilson, S.W.
ID
ZDB-PUB-030730-20
Date
2003
Source
Neuron   39(3): 423-438 (Journal)
Registered Authors
Clarke, Jon, Concha, Miguel, Gilmour, Darren, Kimelman, David, Nicolson, Teresa, Regan, Jenny, Russell, Claire, Sidi, Samuel, Sumoy, Lauro, Wilson, Steve
Keywords
none
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Cell Movement/physiology
  • Central Nervous System/cytology
  • Central Nervous System/embryology
  • Central Nervous System/growth & development
  • Functional Laterality/physiology*
  • Molecular Sequence Data
  • Prosencephalon/cytology
  • Prosencephalon/embryology*
  • Prosencephalon/growth & development*
  • Zebrafish
PubMed
12895418 Full text @ Neuron
Abstract
The mechanisms that establish behavioral, cognitive, and neuroanatomical asymmetries are poorly understood. In this study, we analyze the events that regulate development of asymmetric nuclei in the dorsal forebrain. The unilateral parapineal organ has a bilateral origin, and some parapineal precursors migrate across the midline to form this left-sided nucleus. The parapineal subsequently innervates the left habenula, which derives from ventral epithalamic cells adjacent to the parapineal precursors. Ablation of cells in the left ventral epithalamus can reverse laterality in wild-type embryos and impose the direction of CNS asymmetry in embryos in which laterality is usually randomized. Unilateral modulation of Nodal activity by Lefty1 can also impose the direction of CNS laterality in embryos with bilateral expression of Nodal pathway genes. From these data, we propose that laterality is determined by a competitive interaction between the left and right epithalamus and that Nodal signaling biases the outcome of this competition.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping