ZFIN Person: Concha, Miguel

ZFIN ID: ZDB-PERS-980601-30

ZFIN ID: ZDB-PERS-980601-30

Concha, Miguel

Email:	mconcha@med.uchile.cl
URL:
Affiliation:
Address:	Department of Anatomy and Developmental Biology University College London Gower Street London, WC1E 6BT United Kingdom
Country:
Phone:	44-207-679-3348
Fax:	44-207-679-7349
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Palma, K., Signore, I.A., Meynard, M.M., Ibarra, J., Armijo-Weingart, L., Cayuleo, M., Härtel, S., Concha, M.L. (2022) Ontogenesis of the asymmetric parapineal organ in the zebrafish epithalamus. Frontiers in cell and developmental biology. 10:999265999265

Pulgar, E., Schwayer, C., Guerrero, N., López, L., Márquez, S., Härtel, S., Soto, R., Heisenberg, C.P., Concha, M. (2021) Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. eLIFE. 10:

Figueroa, D., Signore, A., Araneda, O., Contreras, H.R., Concha, M., García, C. (2020) Toxicity and differential oxidative stress effects on zebrafish larvae following exposure to toxins from the okadaic acid group. Journal of toxicology and environmental health. Part A. 83(15-16):573-588

Jara-Wilde, J., Castro, I., Lemus, C.G., Palma, K., Valdés, F., Castañeda, V., Hitschfeld, N., Concha, M.L., Hartel, S. (2020) Optimising adjacent membrane segmentation and parameterisation in multi-cellular aggregates by piecewise active contours. Journal of microscopy. 278(2):59-75

Stanic, K., Reig, G., Wichmann, I.A., Opazo, J.C., Owen, G.I., Corvalán, A.H., Concha, M.L., Amigo, J.D. (2019) The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish. Scientific Reports. 9:7131

Urra, H., Henriquez, D.R., Cánovas, J., Villarroel-Campos, D., Carreras-Sureda, A., Pulgar, E., Molina, E., Hazari, Y.M., Limia, C.M., Alvarez-Rojas, S., Figueroa, R., Vidal, R.L., Rodriguez, D.A., Rivera, C.A., Court, F.A., Couve, A., Qi, L., Chevet, E., Akai, R., Iwawaki, T., Concha, M.L., Glavic, Á., Gonzalez-Billault, C., Hetz, C. (2018) IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nature cell biology. 20(8):942-953

Stanic, K., Quiroz, A., Lemus, C.G., Wichmann, I.A., Corvalán, A.H., Owen, G.I., Opazo, J.C., Concha, M.L., Amigo, J.D. (2018) Expression of RPRM/rprm in the Olfactory System of Embryonic Zebrafish (Danio rerio).. Frontiers in Neuroanatomy. 12:23

Woehlbier, U., Colombo, A., Saaranen, M.J., Pérez, V., Ojeda, J., Bustos, F.J., Andreu, C.I., Torres, M., Valenzuela, V., Medinas, D.B., Rozas, P., Vidal, R.L., Lopez-Gonzalez, R., Salameh, J., Fernandez-Collemann, S., Muñoz, N., Matus, S., Armisen, R., Sagredo, A., Palma, K., Irrazabal, T., Almeida, S., Gonzalez-Perez, P., Campero, M., Gao, F.B., Henny, P., van Zundert, B., Ruddock, L.W., Concha, M.L., Henriquez, J.P., Brown, R.H., Hetz, C. (2016) ALS-linked protein disulfide isomerase variants cause motor dysfunction. The EMBO journal. 35(8):845-65

Colombo, A., Palma, K., Armijo, L., Mione, M., Signore, I.A., Morales, C., Guerrero, N., Meynard, M.M., Pérez, R., Suazo, J., Marcelain, K., Briones, L., Härtel, S., Wilson, S.W., and Concha, M.L. (2013) Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development (Cambridge, England). 140(19):3997-4007

Rojas-Rivera, D., Armisén, R., Colombo, A., Martínez, G., Eguiguren, A.L., Díaz, A., Kiviluoto, S., Rodríguez, D., Patron, M., Rizzuto, R., Bultynck, G., Concha, M.L., Sierralta, J., Stutzin, A., and Hetz, C. (2012) TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell death and differentiation. 19(6):1013-1026

Oteiza, P., Köppen, M., Krieg, M., Pulgar, E., Farias, C., Melo, C., Preibisch, S., Müller, D., Tada, M., Hartel, S., Heisenberg, C.P., and Concha, M.L. (2010) Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development (Cambridge, England). 137(20):3459-3468

Castillo, H.A., Cravo, R.M., Azambuja, A.P., Simões-Costa, M.S., Sura-Trueba, S., Gonzalez, J., Slonimsky, E., Almeida, K., Abreu, J.G., de Almeida, M.A., Sobreira, T.P., de Oliveira, S.H., de Oliveira, P.S., Signore, I.A., Colombo, A., Concha, M.L., Spengler, T.S., Bronner-Fraser, M., Nobrega, M., Rosenthal, N., and Xavier-Neto, J. (2010) Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer. Development (Cambridge, England). 137(3):507-518

Concha, M.L., Signore, I.A., and Colombo, A. (2009) Mechanisms of directional asymmetry in the zebrafish epithalamus. Seminars in cell & developmental biology. 20(4):498-509

Signore, I.A., Guerrero, N., Loosli, F., Colombo, A., Villalón, A., Wittbrodt, J., and Concha, M.L. (2009) Zebrafish and medaka: model organisms for a comparative developmental approach of brain asymmetry. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 364(1519):991-1003

Regan, J.C., Concha, M.L., Roussigne, M., Russell, C., and Wilson, S.W. (2009) An Fgf8-dependent bistable cell migratory event establishes CNS asymmetry. Neuron. 61(1):27-34

Oteíza, P., Köppen, M., Concha, M.L., and Heisenberg, C.P. (2008) Origin and shaping of the laterality organ in zebrafish. Development (Cambridge, England). 135(16):2807-2813

Mione, M., Lele, Z., Kwong, C.T., Concha, M.L., and Clarke, J.D. (2006) Expression of pcp4a in subpopulations of CNS neurons in zebrafish. The Journal of comparative neurology. 495(6):769-787

Colombo, A., Reig, G., Mione, M., and Concha, M.L. (2006) Zebrafish BarH-like genes define discrete neural domains in the early embryo. Gene expression patterns : GEP. 6(4):347-352

Cavodeassi, F., Carreira-Barbosa, F., Young, R., Concha, M., Allende, M.L., Houart, C., Tada, M., and Wilson, S. (2005) Early Stages of Zebrafish Eye Formation Require the Coordinated Activity of Wnt11, Fz5, and the Wnt/Catenin Pathway. Neuron. 47(1):43-56

Aizawa, H., Bianco, I.H., Hamaoka, T., Miyashita, T., Uemura, O., Concha, M.L., Russell, C., Wilson, S.W., and Okamoto, H. (2005) Laterotopic Representation of Left-Right Information onto the Dorso-Ventral Axis of a Zebrafish Midbrain Target Nucleus. Current biology : CB. 15(3):238-243

Teraoka, H., Russell, C., Regan, J., Chandrasekhar, A., Concha, M.L., Yokoyama, R., Higashi, K., Take-Uchi, M., Dong, W., Hiraga, T., Holder, N., and Wilson, S.W. (2004) Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. Journal of neurobiology. 60(3):275-288

Concha, M.L. (2004) The dorsal diencephalic conduction system of zebrafish as a model of vertebrate brain lateralisation. Neuroreport. 15(12):1843-1846

Kudoh, T., Concha, M.L., Houart, C., Dawid, I.B., and Wilson, S.W. (2004) Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. Development (Cambridge, England). 131(15):3581-3592

Ulrich, F., Concha, M.L., Heid, P.J., Voss, E., Witzel, S., Roehl, H., Tada, M., Wilson, S.W., Adams, R.J., Soll, D.R., and Heisenberg, C.P. (2003) Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. Development (Cambridge, England). 130(22):5375-5384

Carreira-Barbosa, F., Concha, M.L., Takeuchi, M., Ueno, N., Wilson, S.W., and Tada, M. (2003) Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development (Cambridge, England). 130(17):4037-4046

Concha, M.L., Russell, C., Regan, J.C., Tawk, M., Sidi, S., Gilmour, D.T., Kapsimali, M., Sumoy, L., Goldstone, K., Amaya, E., Kimelman, D., Nicolson, T., Gründer, S., Gomperts, M., Clarke, J.D.W., and Wilson, S.W. (2003) Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. Neuron. 39(3):423-438

Feldman, B., Concha, M.L., Saude, L., Parsons, M.J., Adams, R.J., Wilson, S.W., and Stemple, D.L. (2002) Lefty antagonism of squint is essential for normal gastrulation. Current biology : CB. 12(24):2129-2135

Lele, Z., Folchert, A., Concha, M., Rauch, G.-J., Geisler, R., Rosa, F., Wilson, S.W., Hammerschmidt, M., and Bally-Cuif, L. (2002) parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube. Development (Cambridge, England). 129(14):3281-3294

Tada, M., Concha, M.I., and Heisenberg, C.-P. (2002) Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in cell & developmental biology. 13(3):251-260

Concha, M.L. and Wilson, S.W. (2001) Asymmetry in the epithalamus of vertebrates. Journal of anatomy. 199(1-2):63-84

Heisenberg, C.P., Houart, C., Take-uchi, M., Rauch, G.J., Young, N., Coutinho, P., Masai, I., Caneparo, L., Concha, M.L., Geisler, R., Dale, T.C., Wilson, S.W., and Stemple, D.L. (2001) A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes & Development. 15(11):1427-1434

Concha, M.L., Burdine, R.D., Russell, C., Schier, A.F., and Wilson, S.W. (2000) A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain. Neuron. 28(2):399-409

Rohr, K.B. and Concha, M.L. (2000) Expression of nk2.1a during early development of the thyroid gland in zebrafish. Mechanisms of Development. 95(1-2):267-270

Heisenberg, C.P., Tada, M., Rauch, G.J., Saude, L., Concha, M.L., Geisler, R., Stemple, D.L., Smith, J.C., and Wilson, S.W. (2000) Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature. 405(6782):76-81

NON-ZEBRAFISH PUBLICATIONS