ZFIN ID: ZDB-PERS-000217-19
Russell, Claire
Email: crussell@rvc.ac.uk
URL: http://www.rvc.ac.uk/AboutUs/Staff/crussell/
Affiliation: Russell Lab
Address: Department of Anatomy and Developmental Biology University College London Gower Street London, WC1E 6BT United Kingdom
Country: United Kingdom
Phone: 44-207-468-1179
Fax: 44-207-388-2342

Research Interests:

Generation of zebrafish models of the Neuronal Ceroid Lipofuscinoses (Batten Disease)

Eye development, optic nerve axon guidance and generation of left-right asymmetry in zebrafish.

Bio Sketch:
Lecturer in Veterinary Basic Sciences, Royal Veterinary College, UK
September 2007-present.

Senior Postdoctoral Fellow
April 2005-August 2007, Genetic analysis of zebrafish development, and creation of zebrafish models of Batten disease, in the laboratory of Dr. Steve Wilson, Deptartment of Anatomy and Developmental Biology, University College London, United Kingdom.

Postdoctoral Researcher
July 1999-April 2005, Genetic analysis of zebrafish development, in the laboratory of Dr. Steve Wilson, Deptartment of Anatomy and Developmental Biology, University College London, United Kingdom.

Postdoctoral Researcher
December 1998-June 1999, Characterisation of mutations and cloning genes involved in axon guidance in Drosophila, in the laboratory of Dr. G. Tear, Department of Molecular Neurology, King's College London, United Kingdom.

Postdoctoral Researcher
June 1995-December 1998, Characterisation of mutations and cloning genes involved in axon guidance in Drosophila, in the laboratory of Dr. G. Tear, Department of Biochemistry, Imperial College, London, United Kingdom.

Contractual Research Assistant
October 1994-June 1995, Drosophila transformation and genetics for study of the rosy gene, for Dr. R. C. Bray, Department of Biology, University of Sussex, United Kingdom.

October 1991-June 1995, D.Phil. performed in the laboratory of Drs. J. R. S. Whittle and R. G. Phillips, Genetics and Development, Department of Biology, University of Sussex, United Kingdom. 'Use of a novel enhancer capture construct in the analysis of imaginal disc development in D. melanogaster.' Russell, C., 1995.

October 1988-June 1991, Degree award: 2.1 B.Sc. (Hons) in Biochemistry at Imperial College, University of London, United Kingdom, 1991. Project: 'Analysis and cloning of an enhancer trap putatively in the Enhancer of split Complex in Drosophila melanogaster' in the laboratory of Dr. D. Hartley.

Research Assistant
June 1991-October 1991, Cloning cDNAs into Drosophila expression vectors under the supervision of Dr. D. Hartley, Imperial College, University of London, United Kingdom.

Huber, R.J., Hughes, S.M., Liu, W., Morgan, A., Tuxworth, R.I., Russell, C. (2019) The contribution of multicellular model organisms to neuronal ceroid lipofuscinosis research. Biochimica et biophysica acta. Molecular basis of disease. 1866(9):165614
Martín-Jiménez, R., Faccenda, D., Allen, E., Reichel, H.B., Arcos, L., Ferraina, C., Strobbe, D., Russell, C., Campanella, M. (2018) Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.. Cell Death & Disease. 9:669
Outtandy, P., Russell, C., Kleta, R., Bockenhauer, D. (2018) Zebrafish as a model for kidney function and disease. Pediatric nephrology (Berlin, Germany). 34(5):751-762
Wager, K., Zdebik, A.A., Fu, S., Cooper, J.D., Harvey, R.J., Russell, C. (2016) Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease). PLoS One. 11:e0157365
Solchenberger, B., Russell, C., Kremmer, E., Haass, C., Schmid, B. (2015) Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology. PLoS One. 10:e0118956
Cunliffe, V.T., Baines, R.A., Giachello, C.N., Lin, W.H., Morgan, A., Reuber, M., Russell, C., Walker, M.C., Williams, R.S. (2015) Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms. Seizure. 24C:44-51
Ivanes, F., Faccenda, D., Gatliff, J., Ahmed, A.A., Cocco, S., Cheng, C.H., Allan, E., Russell, C., Duchen, M.R., Campanella, M. (2014) The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. British journal of pharmacology. 171(18):4193-206
Wager, K., Mahmood, F., Russell, C. (2014) Modelling inborn errors of metabolism in zebrafish. Journal of inherited metabolic disease. 37(4):483-95
Zdebik, A.A., Mahmood, F., Stanescu, H.C., Kleta, R., Bockenhauer, D., and Russell, C. (2013) Epilepsy in kcnj10 Morphant Zebrafish Assessed with a Novel Method for Long-Term EEG Recordings. PLoS One. 8(11):e79765
Wager, K., and Russell, C. (2013) Mitophagy and neurodegeneration: The zebrafish model system. Autophagy. 9(11):1693-1709
Mahmood, F., Mozere, M., Zdebik, A.A., Stanescu, H.C., Tobin, J., Beales, P.L., Kleta, R., Bockenhauer, D., and Russell, C. (2013) Generation and validation of a zebrafish model of EAST (Epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome. Disease models & mechanisms. 6(3):652-60
Mahmood, F., Fu, S., Cooke, J., Wilson, S.W., Cooper, J.D., and Russell, C. (2013) A zebrafish model of CLN2 disease is deficient in tripeptidyl peptidase 1 and displays progressive neurodegeneration accompanied by a reduction in proliferation. Brain : a journal of neurology. 136(Pt 5):1488-507
Brennan, C., Dosch, R., Haramis, A.P., Luckenbacher, T., Martinez-Morales, J.R., Moro, E., Polok, B., Ramesh, T.M., Russell, C., Argenton, F., and Strähle, U. (2010) Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18-22, 2010. Zebrafish. 7(3):305-310
Regan, J.C., Concha, M.L., Roussigne, M., Russell, C., and Wilson, S.W. (2009) An Fgf8-dependent bistable cell migratory event establishes CNS asymmetry. Neuron. 61(1):27-34
Bianco, I.H., Carl, M., Russell, C., Clarke, J.D., and Wilson, S.W. (2008) Brain asymmetry is encoded at the level of axon terminal morphology. Neural Development. 3:9
Cooper, J.D., Russell, C., and Mitchison, H.M. (2006) Progress towards understanding disease mechanisms in small vertebrate models of neuronal ceroid lipofuscinosis. Biochimica et biophysica acta. Molecular basis of disease. 1762(10):873-889
Aizawa, H., Bianco, I.H., Hamaoka, T., Miyashita, T., Uemura, O., Concha, M.L., Russell, C., Wilson, S.W., and Okamoto, H. (2005) Laterotopic Representation of Left-Right Information onto the Dorso-Ventral Axis of a Zebrafish Midbrain Target Nucleus. Current biology : CB. 15(3):238-243
Norton, W.H., Mangoli, M., Lele, Z., Pogoda, H.M., Diamond, B., Mercurio, S., Russell, C., Teraoka, H., Stickney, H.L., Rauch, G.J., Heisenberg, C.P., Houart, C., Schilling, T.F., Frohnhoefer, H.G., Rastegar, S., Neumann, C.J., Gardiner, R.M., Strähle, U., Geisler, R., Rees, M., Talbot, W.S., and Wilson, S.W. (2005) Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development (Cambridge, England). 132(4):645-658
Teraoka, H., Russell, C., Regan, J., Chandrasekhar, A., Concha, M.L., Yokoyama, R., Higashi, K., Take-Uchi, M., Dong, W., Hiraga, T., Holder, N., and Wilson, S.W. (2004) Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. Journal of neurobiology. 60(3):275-288
Paukert, M., Sidi, S., Russell, C., Siba, M., Wilson, S.W., Nicolson, T., and Grunder, S. (2004) A family of acid-sensing ion channels (ASICs) from the zebrafish: Widespread expression in the central nervous system suggests a conserved role in neuronal communication. The Journal of biological chemistry. 279(18):18783-18791
Concha, M.L., Russell, C., Regan, J.C., Tawk, M., Sidi, S., Gilmour, D.T., Kapsimali, M., Sumoy, L., Goldstone, K., Amaya, E., Kimelman, D., Nicolson, T., Gründer, S., Gomperts, M., Clarke, J.D.W., and Wilson, S.W. (2003) Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. Neuron. 39(3):423-438
Russell, C. (2003) The roles of Hedgehogs and Fibroblast Growth Factors in eye development and retinal cell rescue. Vision Research. 43(8):899-912
Concha, M.L., Burdine, R.D., Russell, C., Schier, A.F., and Wilson, S.W. (2000) A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain. Neuron. 28(2):399-409

Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline. Kidd, T. Russell, C., Goodman, C. S. & Tear, G. Neuron 20: 25-33 (1998)

Engineering and expression in Drosophila melanogaster of a xanthine dehydrogenase (rosy) variant. Doyle, W. A. , Burke, J. A., Chovnick, A., Dutton, F. L., Russell C., Whittle, J. R. S. & Bray, R. C. Biochem. Soc. Trans. 24, 31S (1996)