Gene

ret

ID

ZDB-GENE-980526-307

Name

ret proto-oncogene receptor tyrosine kinase

Symbol

ret Nomenclature History

Previous Names

c-ret (1)
cret
etID315074.13 (1)
ret1
wu:fd13h01

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Exhibits protein homodimerization activity. Involved in several processes, including autonomic nervous system development; branchiomeric skeletal muscle development; and pronephros morphogenesis. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Is expressed in nervous system; pharyngeal arch; presumptive enteric nervous system; pronephric duct; and vagal neural crest. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Orthologous to human RET (ret proto-oncogene).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

40 figures from 29 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 23 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ret Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Medullary thyroid carcinoma	155240
		Multiple endocrine neoplasia IIA	171400
		Multiple endocrine neoplasia IIB	162300
		Pheochromocytoma	171300
		{Hirschsprung disease, protection against}	142623
		{Hirschsprung disease, susceptibility to, 1}	142623

Associated With ret Via Experimental Models

Human Disease	Fish	Conditions	Citations
Hirschsprung's disease	ret^wmr1/+; em2Tg/em2Tg	standard conditions	Baker et al., 2022
Hirschsprung's disease	ret^hu2846/+	standard conditions	Heanue et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR002126	Cadherin-like
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR040667	Tyrosine-protein kinase receptor Ret, cadherin like domain 3
Domain	IPR041163	Ret, cadherin like domain 1
Domain	IPR041317	RET, cadherin-like domain 4
Family	IPR016249	Tyrosine-protein kinase, Ret receptor
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR015919	Cadherin-like superfamily

Domain Details Per Protein

Protein	Length	Cadherin-like	Cadherin-like superfamily	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Ret, cadherin like domain 1	RET, cadherin-like domain 4	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase receptor Ret, cadherin like domain 3	Tyrosine-protein kinase, Ret receptor
UniProtKB:A8E7C6 InterPro PDB	1106

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ret-201 (1) Ensembl	Havana	4230 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ret-202 (1) Ensembl	Havana	5094 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ret	polyclonal	ret		Rabbit	IHC WB	Santa Cruz Biotechnology, Inc.	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations