ZFIN Morpholino: MO3-lama5

Target Location

Genome Build: GRCz11Chromosome: 23

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-lama5

Expressed Gene	Anatomy	Figures
eef1a1l1	whole organism	Fig. 3 from Webb et al., 2007
fgf8a	median fin fold	Fig. 7 from Webb et al., 2007
lama5	whole organism	Fig. 3 from Webb et al., 2007

Phenotype

Phenotype resulting from MO3-lama5

Phenotype	Fish	Figures
embryonic medial fin morphogenesis decreased process quality, abnormal	TU + MO3-lama5	Fig. 6 from Nagendran et al., 2015
epidermal basal stratum ecto-epithelial cell oblong, abnormal	TU + MO3-lama5	Fig. 6 from Nagendran et al., 2015
epidermal basal stratum epithelial cell morphogenesis decreased process quality, abnormal	TU + MO3-lama5	Fig. 6 from Nagendran et al., 2015
extension hypoplastic, abnormal	WT + MO3-lama5	Fig. 3 from Webb et al., 2007
median fin fold structure, abnormal	WT + MO3-lama5	Fig. 3 from Webb et al., 2007
pectoral fin structure, abnormal	WT + MO3-lama5	Fig. 3 from Webb et al., 2007

Phenotype of all Fish created by or utilizing MO3-lama5

Phenotype	Fish	Conditions	Figures
embryonic medial fin morphogenesis decreased process quality, abnormal	TU + MO3-lama5	standard conditions	Fig. 6 from Nagendran et al., 2015
epidermal basal stratum ecto-epithelial cell oblong, abnormal	TU + MO3-lama5	standard conditions	Fig. 6 from Nagendran et al., 2015
epidermal basal stratum epithelial cell morphogenesis decreased process quality, abnormal	TU + MO3-lama5	standard conditions	Fig. 6 from Nagendran et al., 2015
median fin fold structure, abnormal	WT + MO3-lama5	standard conditions	Fig. 3 from Webb et al., 2007
extension hypoplastic, abnormal	WT + MO3-lama5	standard conditions	Fig. 3 from Webb et al., 2007
pectoral fin structure, abnormal	WT + MO3-lama5	standard conditions	Fig. 3 from Webb et al., 2007
caudal fin epidermal cell aggregated, exacerbated	WT + MO1-spint1a + MO3-lama5	control	Fig. 5 from Armistead et al., 2020
epidermal basal stratum cell protruding out of epidermis, exacerbated	WT + MO1-spint1a + MO3-lama5	control	Fig. 5 from Armistead et al., 2020
peridermal cell protruding out of epidermis, exacerbated	WT + MO1-spint1a + MO3-lama5	control	Fig. 5 from Armistead et al., 2020
caudal fin epidermal cell aggregated, ameliorated	WT + MO1-spint1a + MO1-st14a + MO3-lama5	control	Fig. 5 from Armistead et al., 2020
epidermal basal stratum cell protruding out of epidermis, ameliorated	WT + MO1-spint1a + MO1-st14a + MO3-lama5	control	Fig. 5 from Armistead et al., 2020
peridermal cell protruding out of epidermis, ameliorated	WT + MO1-spint1a + MO1-st14a + MO3-lama5	control	Fig. 5 from Armistead et al., 2020

Citations

Include unpublished citations

Armistead, J., Hatzold, J., van Roye, A., Fahle, E., Hammerschmidt, M. (2020) Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase. The Journal of cell biology. 219(2):
Gamble, J.T., Reed-Harris, Y., Barton, C.L., La Du, J., Tanguay, R., Greenwood, J.A. (2018) Quantification of glioblastoma progression in zebrafish xenografts: Adhesion to laminin alpha 5 promotes glioblastoma microtumor formation and inhibits cell invasion. Biochemical and Biophysical Research Communications. 506(4):833-839
Williams, M.L.K., Sawada, A., Budine, T., Yin, C., Gontarz, P., Solnica-Krezel, L. (2018) Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes. Nature communications. 9:1319
Nagendran, M., Arora, P., Gori, P., Mulay, A., Ray, S., Jacob, T., Sonawane, M. (2015) Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages. Development (Cambridge, England). 142(2):320-30
Carney, T.J., Feitosa, N.M., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J.M., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, H., Ingham, P.W., and Hammerschmidt, M. (2010) Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel Fraser Syndrome disease genes. PLoS Genetics. 6(4):e1000907
Webb, A.E., Sanderford, J., Frank, D., Talbot, W.S., Driever, W., and Kimelman, D. (2007) Laminin alpha5 is essential for the formation of the zebrafish fins. Developmental Biology. 311(2):369-382

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