Gene

lama5

ID

ZDB-GENE-030131-9823

Name

laminin, alpha 5

Symbol

lama5 Nomenclature History

Previous Names

fra (1)
cb402 (1)
fransen (1)
im:7138247
sb:cb402
unm m538
wu:fb81a10

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have integrin binding activity. Involved in cell-cell adhesion; fin morphogenesis; and protein localization. Predicted to localize to laminin-5 complex. Is expressed in several structures, including axial mesoderm; endoderm; nervous system; pectoral fin bud; and pharynx. Orthologous to human LAMA5 (laminin subunit alpha 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

34 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb402 (39 images)
IMAGE:7138247 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lama5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
bent bone dysplasia syndrome 2	Alliance	?Bent bone dysplasia syndrome 2	620076
		Nephrotic syndrome, type 26	620049

Associated With lama5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000034	Laminin IV
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR008211	Laminin, N-terminal
Domain	IPR009254	Laminin alpha, domain I
Domain	IPR010307	Laminin domain II
Family	IPR050440	Laminin/Netrin Extracellular Matrix
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily