ZFIN Morpholino: MO2-spi1b

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-spi1b

Expressed Gene	Anatomy	Figures
runx1	ventral wall of dorsal aorta hematopoietic multipotent progenitor cell	Fig. S8 from He et al., 2015

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Phenotype

Phenotype resulting from MO2-spi1b

Phenotype	Fish	Figures
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount, abnormal	TU + MO2-spi1b	Fig. S8 from He et al., 2015

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Phenotype of all Fish created by or utilizing MO2-spi1b

Phenotype	Fish	Conditions	Figures
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount, abnormal	TU + MO2-spi1b	standard conditions	Fig. S8 from He et al., 2015
defense response to bacterium disrupted, abnormal	WIK + MO2-spi1b + MO3-spi1b	bacterial treatment: Mycobacterium marinum	Fig. 3 from Clay et al., 2007
defense response to bacterium decreased occurrence, abnormal	WIK + MO2-spi1b + MO3-spi1b	bacterial treatment: Mycobacterium marinum	Fig. 1 , Fig. 6 from Clay et al., 2008
whole organism lacks all parts of type macrophage, abnormal	WIK + MO2-spi1b + MO3-spi1b	bacterial treatment: Mycobacterium marinum	Fig. 5 from Clay et al., 2007
macrophage absent, abnormal	WIK + MO2-spi1b + MO3-spi1b	bacterial treatment: Mycobacterium marinum	Fig. 6 from Clay et al., 2008

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Citations

Include unpublished citations

Nielson, J.A., Davis, J.M. (2023) Roles for Microglia in Cryptococcal Brain Dissemination in the Zebrafish Larva. Microbiology spectrum. 11(2):e0431522
Ding, Y., Li, Y., Zhao, Z., Cliff Zhang, Q., Liu, F. (2021) The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. eLIFE. 10:
Scherer, A.K., Blair, B.A., Park, J., Seman, B.G., Kelley, J.B., Wheeler, R.T. (2020) Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast. PLoS pathogens. 16:e1008414
Cambier, C.J., O'Leary, S.M., O'Sullivan, M.P., Keane, J., Ramakrishnan, L. (2017) Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages. Immunity. 47(3):552-565.e4
Madigan, C.A., Cambier, C.J., Kelly-Scumpia, K.M., Scumpia, P.O., Cheng, T.Y., Zailaa, J., Bloom, B.R., Moody, D.B., Smale, S.T., Sagasti, A., Modlin, R.L., Ramakrishnan, L. (2017) A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 170:973-985.e10
Mesureur, J., Feliciano, J.R., Wagner, N., Gomes, M.C., Zhang, L., Blanco-Gonzalez, M., van der Vaart, M., O'Callaghan, D., Meijer, A.H., Vergunst, A.C. (2017) Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. PLoS pathogens. 13:e1006437
Halloum, I., Carrère-Kremer, S., Blaise, M., Viljoen, A., Bernut, A., Le Moigne, V., Vilchèze, C., Guérardel, Y., Lutfalla, G., Herrmann, J.L., Jacobs, W.R., Kremer, L. (2016) Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent. Proceedings of the National Academy of Sciences of the United States of America. 113(29):E4228-37
Willis, A.R., Moore, C., Mazon-Moya, M., Krokowski, S., Lambert, C., Till, R., Mostowy, S., Sockett, R.E. (2016) Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae. Current biology : CB. 26(24):3343-3351
Belon, C., Soscia, C., Bernut, A., Laubier, A., Bleves, S., Blanc-Potard, A.B. (2015) A Macrophage Subversion Factor Is Shared by Intracellular and Extracellular Pathogens. PLoS pathogens. 11:e1004969
Bernut, A., Dupont, C., Sahuquet, A., Herrmann, J.L., Lutfalla, G., Kremer, L. (2015) Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos. Journal of visualized experiments : JoVE. (103):e53130

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