ZFIN Morpholino: MO2-ezrb

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-ezrb

Expressed Gene	Anatomy	Figures
ctslb	prechordal plate	Fig. 7 from Link et al., 2006
dlx3b	neural keel	Fig. 7 from Link et al., 2006
ezrb	(not) pronephric duct apical plasma membrane	Fig. 2 from Xu et al., 2017
tbxta	notochord	Fig. 7 from Link et al., 2006

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Phenotype

Phenotype resulting from MO2-ezrb

Phenotype	Fish	Figures
anterior axial hypoblast decreased cellular motility, abnormal	WT + MO2-ezrb	Fig. 3 from Diz-Munoz et al., 2010
anterior axial hypoblast bleb increased amount, abnormal	WT + MO2-ezrb	Fig. 2 from Diz-Munoz et al., 2010
anterior axial hypoblast bleb increased size, abnormal	WT + MO2-ezrb	Fig. 2 from Diz-Munoz et al., 2010
anterior axial hypoblast filopodium decreased amount, abnormal	WT + MO2-ezrb	Fig. 2 from Diz-Munoz et al., 2010
anterior axial hypoblast lamellipodium decreased amount, abnormal	WT + MO2-ezrb	Fig. 2 from Diz-Munoz et al., 2010

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Phenotype of all Fish created by or utilizing MO2-ezrb

Phenotype	Fish	Conditions	Figures
pronephric tubule has fewer parts of type pronephric tubule microvillus, abnormal	AB/TL + MO2-ezrb	standard conditions	Fig. 3 from Epting et al., 2015
pronephros cystic, abnormal	AB/TL + MO2-ezrb	standard conditions	Fig. 3 from Epting et al., 2015
brain hydrocephalic, abnormal	AB/TL + MO2-ezrb	standard conditions	Fig. 3 from Epting et al., 2015
pronephros cilium assembly decreased process quality, abnormal	AB/TL + MO2-ezrb	standard conditions	Fig. 3 from Epting et al., 2015
pronephric glomerulus cystic, abnormal	TU + MO2-ezrb	standard conditions	Fig. 2, Fig. 3 from Xu et al., 2017

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Citations

Include unpublished citations

Prince, D.J., Jessen, J.R. (2019) Dorsal convergence of gastrula cells requires a Vangl2 and adhesion protein-dependent change in protrusive activity. Development (Cambridge, England). 146(22):
Sidhaye, J., Norden, C. (2017) Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis. eLIFE. 6
Xu, W., Jin, M., Hu, R., Wang, H., Zhang, F., Yuan, S., Cao, Y. (2017) The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society of Nephrology : JASN. 28(1):118-129
Diz-Muñoz, A., Romanczuk, P., Yu, W., Bergert, M., Ivanovitch, K., Salbreux, G., Heisenberg, C.P., Paluch, E.K. (2016) Steering cell migration by alternating blebs and actin-rich protrusions. BMC Biology. 14:74
Epting, D., Slanchev, K., Boehlke, C., Hoff, S., Loges, N.T., Yasunaga, T., Indorf, L., Nestel, S., Lienkamp, S.S., Omran, H., Kuehn, E.W., Ronneberger, O., Walz, G., Kramer-Zucker, A. (2015) The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Development (Cambridge, England). 142:174-84
Diz-Munoz, A., Krieg, M., Bergert, M., Ibarlucea-Benitez, I., Muller, D.J., Paluch, E., and Heisenberg, C.P. (2010) Control of Directed Cell Migration In Vivo by Membrane-to-Cortex Attachment. PLoS Biology. 8(11):e1000544
Link, V., Carvalho, L., Castanon, I., Stockinger, P., Shevchenko, A., and Heisenberg, C.P. (2006) Identification of regulators of germ layer morphogenesis using proteomics in zebrafish. Journal of Cell Science. 119(10):2073-2083

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