ZFIN Morpholino: MO4-isl1a

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-isl1a

No data available

Phenotype

Phenotype resulting from MO4-isl1a

Phenotype	Fish	Figures
heart edematous, abnormal	AB + MO4-isl1a	Fig. 7 from Nasif et al., 2015
heart isl1a expression increased distribution, abnormal	s883Tg + MO4-isl1a	Fig. 4 from Witzel et al., 2012
heart development disrupted, abnormal	AB + MO4-isl1a	Fig. 7 from Nasif et al., 2015
hypothalamus neuron decreased amount, abnormal	AB + MO4-isl1a	Fig. 7 from Nasif et al., 2015
peripheral nervous system neuron axonogenesis decreased occurrence, abnormal	WT + MO4-isl1a	Fig. 4 from Tanaka et al., 2011

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Phenotype of all Fish created by or utilizing MO4-isl1a

Phenotype	Fish	Conditions	Figures
heart development disrupted, abnormal	AB + MO4-isl1a	standard conditions	Fig. 7 from Nasif et al., 2015
post-vent region curved ventral, abnormal	AB + MO4-isl1a	standard conditions	Fig. 7 from Nasif et al., 2015
hypothalamus neuron decreased amount, abnormal	AB + MO4-isl1a	standard conditions	Fig. 7 from Nasif et al., 2015
whole organism decreased size, abnormal	AB + MO4-isl1a	standard conditions	Fig. 7 from Nasif et al., 2015
heart edematous, abnormal	AB + MO4-isl1a	standard conditions	Fig. 7 from Nasif et al., 2015

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Citations

Include unpublished citations

Guerra, A., Germano, R.F., Stone, O., Arnaout, R., Guenther, S., Ahuja, S., Uribe, V., Vanhollebeke, B., Stainier, D.Y., Reischauer, S. (2018) Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. eLIFE. 7
Nasif, S., de Souza, F.S., González, L.E., Yamashita, M., Orquera, D.P., Low, M.J., Rubinstein, M. (2015) Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. Proceedings of the National Academy of Sciences of the United States of America. 112(15):E1861-70
Witzel, H.R., Jungblut, B., Choe, C.P., Crump, J.G., Braun, T., and Dobreva, G. (2012) The LIM Protein Ajuba Restricts the Second Heart Field Progenitor Pool by Regulating Isl1 Activity. Developmental Cell. 23(1):58-70
Tanaka, H., Nojima, Y., Shoji, W., Sato, M., Nakayama, R., Ohshima, T., and Okamoto, H. (2011) Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(1):9-22
Hutchinson, S.A., and Eisen, J.S. (2006) Islet1 and Islet2 have equivalent abilities to promote motoneuron formation and to specify motoneuron subtype identity. Development (Cambridge, England). 133(11):2137-2147

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