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General Information
ZIRC
ZFIN ID: ZDB-MRPHLNO-051026-3
Morpholino Name: MO1-smn1
Target: smn1 (1)
Sequence:
5' - CGACATCTTCTGCACCATTGGC - 3'
   
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  (Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.)
TARGET LOCATION
No data available
CONSTRUCTS WITH SEQUENCES FROM MO1-smn1 No data available
GENE EXPRESSION
Gene expression in Wild Types + MO1-smn1
Expressed Gene Anatomy Figures
ncaldb Fig. 3 from Riessland et al., 2017
pls3 Fig. 1 from Hao et al., 2012
smn1 Fig. 3 from Riessland et al., 2017
Fig. 1 from Powis et al., 2016
Fig. 5Fig. 6 from Winkler et al., 2005
PHENOTYPE
Phenotype resulting from MO1-smn1
Phenotype Figures
axon extension process quality, abnormal Fig. 7 with image from Chitramuthu et al., 2010
axonogenesis disrupted, abnormal Fig. 5 from Sleigh et al., 2014
Fig. 4 from Oprea et al., 2008
CaP motoneuron morphology, abnormal Fig. 4 from McWhorter et al., 2008
CaP motoneuron axon branched, abnormal Fig. 4 from See et al., 2014
Fig. 7 with image from Chitramuthu et al., 2010
CaP motoneuron axon decreased length, abnormal Fig. 3 from Riessland et al., 2017
Fig. 7 with image from Chitramuthu et al., 2010
CaP motoneuron axon increased branchiness, abnormal Fig. 3 from Riessland et al., 2017
CaP motoneuron axon truncated, abnormal Fig. 4 from See et al., 2014
CaP motoneuron axon extension involved in axon guidance decreased process quality, abnormal Fig. 3 from Riessland et al., 2017
CaP motoneuron collateral sprouting increased occurrence, abnormal Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular junction decreased width, abnormal Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular junction development decreased process quality, abnormal Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular synaptic transmission decreased process quality, abnormal Fig. 3 from Riessland et al., 2017
fast muscle cell synaptic cleft decreased width, abnormal Fig. 3 from Riessland et al., 2017
motor neuron decreased amount, abnormal Fig. 5 from Sleigh et al., 2014
motor neuron axon absent, abnormal Fig. 5 from Sleigh et al., 2014
motor neuron axon bifurcated, abnormal Fig. 5 from Sleigh et al., 2014
motor neuron axon branched, abnormal Fig. 1 from Lyon et al., 2014
motor neuron axon branchiness, abnormal Fig. 1 from Powis et al., 2016
Fig. 5 from Miller et al., 2015
Fig. 6 from Wishart et al., 2014
Fig. 5 from Winkler et al., 2005
motor neuron axon decreased length, abnormal Fig. 2 from Edens et al., 2015
motor neuron axon increased branchiness, abnormal Fig. 8 from Hosseinibarkooie et al., 2016
Fig. 2 from Edens et al., 2015
Table S9 from Van Hoecke et al., 2012
motor neuron axon mislocalised, abnormal Fig. 6 with image from Lotti et al., 2012
motor neuron axon morphology, abnormal Fig. 1 from Powis et al., 2016
Fig. 2 with image from McGovern et al., 2015
Fig. 5 from Miller et al., 2015
Fig. 5 from Wiley et al., 2014
Fig. 4 from Oprea et al., 2008
motor neuron axon truncated, abnormal Fig. 8 from Hosseinibarkooie et al., 2016
Fig. 1 from Powis et al., 2016
Fig. 5 from Miller et al., 2015
Fig. 1 from Lyon et al., 2014
Fig. 5 from Sleigh et al., 2014
Fig. 6 from Wishart et al., 2014
Fig. S8Table S9 from Van Hoecke et al., 2012
Fig. 5 from Winkler et al., 2005
motor neuron axon extension disrupted, abnormal Fig. 2 with image from McGovern et al., 2015
motor neuron axon extension process quality, abnormal Fig. 2 from Edens et al., 2015
motor neuron axon guidance decreased process quality, abnormal Fig. 6 with image from Lotti et al., 2012
motor neuron axon guidance disrupted, abnormal Fig. 5 from Sleigh et al., 2014
mRNA splicing, via spliceosome decreased process quality, abnormal Fig. 2 from See et al., 2014
primary motor neuron axon decreased length, abnormal Fig. 3 with imageFig. 5 with imageFig. 6 with image from Boyd et al., 2017
primary motor neuron axon terminus swollen, abnormal Fig. 5 with imageFig. 6 with image from Boyd et al., 2017
primary motor neuron axonogenesis disrupted, abnormal Fig. 3 with imageFig. 5 with imageFig. 6 with image from Boyd et al., 2017
swimming decreased rate, abnormal Fig. S3 from Riessland et al., 2017
swimming behavior process quality, abnormal Fig. 1 from Powis et al., 2016
whole organism smn1 expression decreased amount, abnormal Fig. 3 from Riessland et al., 2017
Fig. 1 from Powis et al., 2016
whole organism Ab2-atp5a labeling decreased amount, abnormal Fig. 2 from Boyd et al., 2017
whole organism Ab3-ub labeling decreased amount, abnormal Fig. 1 from Powis et al., 2016
whole organism aerobic respiration decreased efficacy, abnormal Fig. 2 from Boyd et al., 2017
whole organism ATP generation from ADP decreased efficacy, abnormal Fig. 2 from Boyd et al., 2017
whole organism mitochondrion decreased functionality, abnormal Fig. 2 from Boyd et al., 2017

Phenotype of all Fish created by or utilizing MO1-smn1
Phenotype Fish Conditions Figures
motor neuron axon truncated, abnormal AB + MO1-smn1 standard conditions Fig. S8Table S9 from Van Hoecke et al., 2012
motor neuron axon increased branchiness, abnormal AB + MO1-smn1 standard conditions Table S9 from Van Hoecke et al., 2012
CaP motoneuron morphology, abnormal AB + MO1-smn1 standard conditions Fig. 4 from McWhorter et al., 2008
whole organism smn1 expression decreased amount, abnormal AB + MO1-smn1 standard conditions Fig. 1 from Powis et al., 2016
whole organism Ab3-ub labeling decreased amount, abnormal AB + MO1-smn1 standard conditions Fig. 1 from Powis et al., 2016
motor neuron axon truncated, abnormal WT + MO1-smn1 standard conditions Fig. 5 from Winkler et al., 2005
primary motor neuron axon decreased length, abnormal WT + MO1-smn1 standard conditions Fig. 5 with image from Boyd et al., 2017
motor neuron axon morphology, abnormal WT + MO1-smn1 standard conditions Fig. 4 from Oprea et al., 2008
whole organism aerobic respiration decreased efficacy, abnormal WT + MO1-smn1 standard conditions Fig. 2 from Boyd et al., 2017
whole organism ATP generation from ADP decreased efficacy, abnormal WT + MO1-smn1 standard conditions Fig. 2 from Boyd et al., 2017
motor neuron axon branchiness, abnormal WT + MO1-smn1 standard conditions Fig. 5 from Winkler et al., 2005
whole organism Ab2-atp5a labeling decreased amount, abnormal WT + MO1-smn1 standard conditions Fig. 2 from Boyd et al., 2017
CaP motoneuron axon decreased length, abnormal WT + MO1-smn1 standard conditions Fig. 7 with image from Chitramuthu et al., 2010
primary motor neuron axon terminus swollen, abnormal WT + MO1-smn1 standard conditions Fig. 5 with image from Boyd et al., 2017
axon extension process quality, abnormal WT + MO1-smn1 standard conditions Fig. 7 with image from Chitramuthu et al., 2010
whole organism mitochondrion decreased functionality, abnormal WT + MO1-smn1 standard conditions Fig. 2 from Boyd et al., 2017
CaP motoneuron axon branched, abnormal WT + MO1-smn1 standard conditions Fig. 4 from See et al., 2014
Fig. 7 with image from Chitramuthu et al., 2010
mRNA splicing, via spliceosome decreased process quality, abnormal WT + MO1-smn1 standard conditions Fig. 2 from See et al., 2014
axonogenesis disrupted, abnormal WT + MO1-smn1 standard conditions Fig. 4 from Oprea et al., 2008
CaP motoneuron axon truncated, abnormal WT + MO1-smn1 standard conditions Fig. 4 from See et al., 2014
primary motor neuron axonogenesis disrupted, abnormal WT + MO1-smn1 standard conditions Fig. 5 with image from Boyd et al., 2017
fast muscle cell synaptic cleft decreased width, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
CaP motoneuron axon decreased length, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
motor neuron axon morphology, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 1 from Powis et al., 2016
CaP motoneuron axon increased branchiness, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
axonogenesis disrupted, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 5 from Sleigh et al., 2014
motor neuron axon guidance disrupted, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 5 from Sleigh et al., 2014
primary motor neuron axon decreased length, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 with imageFig. 6 with image from Boyd et al., 2017
motor neuron axon truncated, abnormal ml2Tg + MO1-smn1(EKW, TL) standard conditions Fig. 6 from Wishart et al., 2014
swimming decreased rate, abnormal ml2Tg + MO1-smn1 standard conditions Fig. S3 from Riessland et al., 2017
primary motor neuron axonogenesis disrupted, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 with imageFig. 6 with image from Boyd et al., 2017
CaP motoneuron axon extension involved in axon guidance decreased process quality, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
motor neuron axon increased branchiness, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 8 from Hosseinibarkooie et al., 2016
motor neuron decreased amount, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 5 from Sleigh et al., 2014
primary motor neuron axon terminus swollen, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 6 with image from Boyd et al., 2017
motor neuron axon bifurcated, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 5 from Sleigh et al., 2014
primary motor neuron axon length, ameliorated ml2Tg + MO1-smn1 chemical treatment: terazosin Fig. 6 with image from Boyd et al., 2017
fast muscle cell neuromuscular synaptic transmission decreased process quality, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
motor neuron axon branchiness, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 1 from Powis et al., 2016
motor neuron axon absent, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 5 from Sleigh et al., 2014
whole organism smn1 expression decreased amount, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
swimming behavior process quality, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 1 from Powis et al., 2016
fast muscle cell neuromuscular junction decreased width, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
primary motor neuron axonogenesis process efficacy, ameliorated ml2Tg + MO1-smn1 chemical treatment: terazosin Fig. 6 with image from Boyd et al., 2017
motor neuron axon branchiness, abnormal ml2Tg + MO1-smn1(EKW, TL) standard conditions Fig. 6 from Wishart et al., 2014
fast muscle cell neuromuscular junction development decreased process quality, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
CaP motoneuron collateral sprouting increased occurrence, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
motor neuron axon truncated, abnormal ml2Tg + MO1-smn1 standard conditions Fig. 8 from Hosseinibarkooie et al., 2016
Fig. 1 from Powis et al., 2016
Fig. 5 from Sleigh et al., 2014
motor neuron axon increased branchiness, abnormal ml2Tg + MO1-smn1 + MO2-smn1 standard conditions Fig. 4 with image from Akten et al., 2011
motor neuron axon truncated, abnormal ml2Tg + MO1-smn1 + MO2-smn1 standard conditions Fig. 4 with image from Akten et al., 2011
motor neuron axon morphology, abnormal ml2Tg + MO1-smn1 + MO2-smn1 standard conditions Fig. 4 with image from Akten et al., 2011
motor neuron axon mislocalised, abnormal os26Tg + MO1-smn1 standard conditions Fig. 6 with image from Lotti et al., 2012
motor neuron axon truncated, abnormal os26Tg + MO1-smn1 standard conditions Fig. 1 from Lyon et al., 2014
motor neuron axon extension disrupted, abnormal os26Tg + MO1-smn1 standard conditions Fig. 2 with image from McGovern et al., 2015
motor neuron axon guidance decreased process quality, abnormal os26Tg + MO1-smn1 standard conditions Fig. 6 with image from Lotti et al., 2012
motor neuron axon morphology, abnormal os26Tg + MO1-smn1 standard conditions Fig. 2 with image from McGovern et al., 2015
Fig. 5 from Wiley et al., 2014
motor neuron axon branched, abnormal os26Tg + MO1-smn1 standard conditions Fig. 1 from Lyon et al., 2014
motor neuron axon branchiness, abnormal vu12Tg + MO1-smn1 standard conditions Fig. 5 from Miller et al., 2015
motor neuron axon truncated, abnormal vu12Tg + MO1-smn1 standard conditions Fig. 5 from Miller et al., 2015
motor neuron axon increased branchiness, abnormal vu12Tg + MO1-smn1 standard conditions Fig. 2 from Edens et al., 2015
motor neuron axon decreased length, abnormal vu12Tg + MO1-smn1 standard conditions Fig. 2 from Edens et al., 2015
motor neuron axon extension process quality, abnormal vu12Tg + MO1-smn1 standard conditions Fig. 2 from Edens et al., 2015
motor neuron axon morphology, abnormal vu12Tg + MO1-smn1 standard conditions Fig. 5 from Miller et al., 2015
whole organism lethal (sensu genetics), abnormal WT + MO1-pls3 + MO1-smn1 standard conditions text only from Oprea et al., 2008
whole organism ncaldb expression absent, abnormal ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
CaP motoneuron axon length, ameliorated ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
CaP motoneuron axon extension involved in axon guidance process quality, ameliorated ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular synaptic transmission process quality, ameliorated ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
whole organism smn1 expression decreased amount, abnormal ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
swimming rate, ameliorated ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. S3 from Riessland et al., 2017
CaP motoneuron axon increased branchiness, abnormal ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
fast muscle cell synaptic cleft width, ameliorated ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular junction width, ameliorated ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
CaP motoneuron collateral sprouting increased occurrence, abnormal ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular junction development process quality, ameliorated ml2Tg + MO1-ncaldb + MO1-smn1 standard conditions Fig. 3 from Riessland et al., 2017
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CITATIONS (26)