FIGURE

Fig. 7

ID

ZDB-FIG-101118-7

Publication

Chitramuthu et al., 2010 - Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1

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Fig. 7

Progranulin protects CaP MNs in a model of Spinal Muscular Atrophy SMA): zfPGRN-A mRNA co-injection partially rescues SMN-MO induced CaP MN defects. (A, B) Lateral views of embryos injected with 9 ng SMN-MO and (C) embryos co-injected with 9 ng SMN-MO + 100 pg zfPGRN-A mRNA. Symbols as in Figure 1. Truncated (A) and branched (B) neurons were observed upon injection of SMN MO while co-injection with zfPGRN-A rescued truncation (white arrow) and increased axon branching (C). Abbreviations: T-truncation; B-Branching. Scale Bar = 50 μm.

Expression Data

Antibody:	znp-1
Fish:	WT + MO1-smn1
Knockdown Reagent:	MO1-smn1
Anatomical Term:	CaP motoneuron axon
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-smn1
Knockdown Reagent:	MO1-smn1
Observed In:	axon extension CaP motoneuron axon
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Neurodegener.