ZFIN ID: ZDB-FISH-150901-18390
Fish name: ml2Tg + MO1-smn1
Genotype: ml2Tg
Targeting Reagent: MO1-smn1
HUMAN DISEASE MODELED by ml2Tg + MO1-smn1
Human Disease Conditions Citations
spinal muscular atrophy standard conditions Riessland et al., 2017
GENE EXPRESSION
Gene expression in ml2Tg + MO1-smn1
Reporter gene expression
Expressed Gene Structure Conditions Figures
GFP standard conditions Fig. 6 with image from Boyd et al., 2017
PHENOTYPE
Phenotype in ml2Tg + MO1-smn1
Phenotype Conditions Figures
axonogenesis disrupted, abnormal standard conditions Fig. 5 from Sleigh et al., 2014
CaP motoneuron axon decreased length, abnormal standard conditions Fig. 3 from Riessland et al., 2017
CaP motoneuron axon increased branchiness, abnormal standard conditions Fig. 3 from Riessland et al., 2017
CaP motoneuron axon extension involved in axon guidance decreased process quality, abnormal standard conditions Fig. 3 from Riessland et al., 2017
CaP motoneuron collateral sprouting increased occurrence, abnormal standard conditions Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular junction decreased width, abnormal standard conditions Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular junction development decreased process quality, abnormal standard conditions Fig. 3 from Riessland et al., 2017
fast muscle cell neuromuscular synaptic transmission decreased process quality, abnormal standard conditions Fig. 3 from Riessland et al., 2017
fast muscle cell synaptic cleft decreased width, abnormal standard conditions Fig. 3 from Riessland et al., 2017
motor neuron decreased amount, abnormal standard conditions Fig. 5 from Sleigh et al., 2014
motor neuron axon absent, abnormal standard conditions Fig. 5 from Sleigh et al., 2014
motor neuron axon bifurcated, abnormal standard conditions Fig. 5 from Sleigh et al., 2014
motor neuron axon branchiness, abnormal standard conditions Fig. 1 from Powis et al., 2016
motor neuron axon increased branchiness, abnormal standard conditions Fig. 8 from Hosseinibarkooie et al., 2016
motor neuron axon morphology, abnormal standard conditions Fig. 1 from Powis et al., 2016
motor neuron axon truncated, abnormal standard conditions Fig. 8 from Hosseinibarkooie et al., 2016
Fig. 1 from Powis et al., 2016
Fig. 5 from Sleigh et al., 2014
motor neuron axon guidance disrupted, abnormal standard conditions Fig. 5 from Sleigh et al., 2014
primary motor neuron axon decreased length, abnormal standard conditions Fig. 3 with image,  Fig. 6 with image from Boyd et al., 2017
primary motor neuron axon length, ameliorated chemical treatment: terazosin Fig. 6 with image from Boyd et al., 2017
primary motor neuron axon terminus swollen, abnormal standard conditions Fig. 6 with image from Boyd et al., 2017
primary motor neuron axonogenesis disrupted, abnormal standard conditions Fig. 3 with image,  Fig. 6 with image from Boyd et al., 2017
primary motor neuron axonogenesis process efficacy, ameliorated chemical treatment: terazosin Fig. 6 with image from Boyd et al., 2017
swimming decreased rate, abnormal standard conditions Fig. S3 from Riessland et al., 2017
swimming behavior process quality, abnormal standard conditions Fig. 1 from Powis et al., 2016
whole organism smn1 expression decreased amount, abnormal standard conditions Fig. 3 from Riessland et al., 2017

CITATIONS  (6)

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