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Chen et al., 2026 - Sirt1 coordinates the mitochondrial UPR and myocellular proteostasis to preserve muscle integrity during muscle atrophy in zebrafish

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FIGURE 3 Sirt1 and the UPR^mt enhance the mFAO to preserve muscle integrity during muscle atrophy. (a) qRT-PCR analysis of the skeletal muscle from DEXA-treated adult zebrafish showing the expression of the mitochondrial fatty acid oxidation (mFAO) genes cpt1b, acadm, acsf2, and acat1 (*p < 0.05, t-test, two-tailed, error bar indicates s.d.). (b) qRT-PCR analysis of wild-type or the ubl5 knockdown (ubl5-mo) zebrafish larvae treated with DEXA showing the DEXA-induced fold increase of the UPR^mt genes hspd1, hspa9, lonp1, and clpp (*p < 0.05, t-test, two-tailed, error bar indicates s.d.). (c) qRT-PCR analysis of wild-type or the ubl5 knockdown (ubl5-mo) zebrafish larvae treated with DEXA showing the expression of cpt1b (*p < 0.05, t-test, two-tailed, error bar indicates s.d.). (d) Representative confocal microscopy images of Alexa488-phalloidin-stained wild-type, the sirt1 mutant, and the ubl5 knockdown (ubl5-mo) zebrafish larvae treated with DEXA. Boxplot shows quantification of larvae with 0, 1–6, or ≥ 7 detached muscle fibers (*p < 0.05, Chi-square test. Arrows indicate examples of detached muscle fibers. Scale bar represents 50 µM).

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol