Gene

acat1

ID
ZDB-GENE-040808-68
Name
acetyl-CoA acetyltransferase 1
Symbol
acat1 Nomenclature History
Previous Names
  • fd16h07
  • fd20g06
  • wu:fd16h07
  • wu:fd20g06
  • zgc:86832
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to localize to mitochondrion. Is expressed in liver. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acat1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
beta-ketothiolase deficiency Alliance Alpha-methylacetoacetic aciduria 203750
Associated With acat1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR020610 Thiolase, active site
Active_site IPR020615 Thiolase, acyl-enzyme intermediate active site
Conserved_site IPR020613 Thiolase, conserved site
Domain IPR020616 Thiolase, N-terminal
Domain IPR020617 Thiolase, C-terminal
Family IPR002155 Thiolase
Homologous_superfamily IPR016039 Thiolase-like
Domain Details Per Protein
Protein Length Thiolase Thiolase, active site Thiolase, acyl-enzyme intermediate active site Thiolase, conserved site Thiolase, C-terminal Thiolase-like Thiolase, N-terminal
UniProtKB:Q6AZA0 420
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations