acat1

ID

ZDB-GENE-040808-68

Name

acetyl-CoA acetyltransferase 1

Symbol

acat1 Nomenclature History

Previous Names

fd16h07
fd20g06
wu:fd16h07
wu:fd20g06
zgc:86832

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in intestine and liver. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7157078 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With acat1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
beta-ketothiolase deficiency	Alliance	Alpha-methylacetoacetic aciduria	203750

Associated With acat1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR020610	Thiolase, active site
Active_site	IPR020615	Thiolase, acyl-enzyme intermediate active site
Conserved_site	IPR020613	Thiolase, conserved site
Domain	IPR020616	Thiolase, N-terminal
Domain	IPR020617	Thiolase, C-terminal
Family	IPR002155	Thiolase
Homologous_superfamily	IPR016039	Thiolase-like