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FIGURE 3

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ZDB-IMAGE-230724-40

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Ab5-elavl

Publication

Chi et al., 2023 - The interplay of common genetic variants NRG1 rs2439302 and RET rs2435357 increases the risk of developing Hirschsprung's disease

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FIGURE 3

Phenotypes of nrg1 and ret knockdown zebrafish. (A) qRT-PCR analysis of relative expression levels of nrg1 and ret in wildtype, nrg1^−/−, ret^−/−, and nrg1^−/−ret^−/− zebrafish embryos at 72 hpf. (B) The survival and deformity rate of wildtype, nrg1^−/−, ret^−/−, and nrg1^−/−ret^−/− zebrafish at 72 hpf. (C) Whole-mount in situ hybridization in wildtype, nrg1^−/−, ret^−/−, and nrg1^−/−ret^−/− embryos at 72 hpf for nrg1, ret, and sox10. White arrows indicated the end of the positive expression of each gene. (D) Immunofluorescence staining and quantitative analysis of a neuronal marker HuC/D in wildtype, nrg1^−/−, ret^−/−, and nrg1^−/−ret^−/− embryos at 72 hpf.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol