Fig. 4
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Fig. 4
Fig. 4. Stabilins are an important player in zebrafish total-body cholesterol homeostasis after challenged with a 10 day high cholesterol diet (HCD). (A) Relative expression of stab1 and 2 in ABTL zebrafish (15 dpf old) after 10 day normal (CTRL) or either 10 day high cholesterol diet (HCD). (B) Whole body total cholesterol levels in 15dpf ABTL and stab1−/−stab2−/− zebrafish fed with a HCD for 10 days. (C) The effect of stab1 and 2 deficiency after 10 days of HCD on relative expression of genes involved in cholesterol acquisition (D) scavenging and (E) cholesterol efflux. Means ± SEM (n = 7; pool of 5 fish); p < 0.01**; p < 0.001***.