Gene
abca1a
- ID
- ZDB-GENE-031006-12
- Name
- ATP-binding cassette, sub-family A (ABC1), member 1A
- Symbol
- abca1a Nomenclature History
- Previous Names
-
- abca1
- cb939 (1)
- fa03d03
- im:6795541
- wu:fa03d03
- wu:fj13h01
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled transmembrane transporter activity; phosphatidylcholine floppase activity; and phosphatidylserine floppase activity. Acts upstream of or within regulation of cholesterol efflux and sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including blood vessel; central nervous system; neural tube; pleuroperitoneal region; and segmental plate. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb939 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa928 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa2010 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa5800 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9624 | Allele with one point mutation | Intron 29 | Splice Site, Cryptic Acceptor Splice Site, Exon Loss | ENU | |
| sa12376 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13007 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15548 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32775 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39699 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko1040a | Allele with one insertion | Unknown | Unknown | CRISPR |
1 - 10 of 10
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-abca1a | China Zebrafish Resource Center (CZRC) | |
| CRISPR2-abca1a | Keatinge et al., 2021 | |
| CRISPR3-abca1a | Keatinge et al., 2021 | |
| MO1-abca1a | N/A | Fang et al., 2013 |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hypoalphalipoproteinemia 1 | Alliance | HDL deficiency, familial, 1 | 604091 |
| Tangier disease | Alliance | Tangier disease | 205400 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ABC-2 type transporter, transmembrane domain | ABC transporter A | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A446 | InterPro | 2268 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
abca1a-202
(1)
|
Ensembl | 9,428 nt | ||
| mRNA |
abca1a-203
(1)
|
Ensembl | 9,626 nt | ||
| ncRNA |
abca1a-002
(1)
|
Ensembl | 697 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-149G8 | ZFIN Curated Data | |
| Encodes | EST | cb939 | Thisse et al., 2001 | |
| Encodes | EST | fa03d03 | ||
| Encodes | EST | fj13h01 | ||
| Encodes | EST | IMAGE:6795541 |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309465 (1) | 9626 nt | ||
| Genomic | GenBank:BX004781 (1) | 169991 nt | ||
| Polypeptide | UniProtKB:B8A446 (1) | 2268 aa |
- Gora, A.H., Rehman, S., Dias, J., Fernandes, J.M.O., Olsvik, P.A., Sørensen, M., Kiron, V. (2023) Protective mechanisms of a microbial oil against hypercholesterolemia: evidence from a zebrafish model. Frontiers in nutrition. 10:11611191161119
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Wang, Y., Pan, Y., Hou, M., Luo, R., He, J., Lin, F., Xia, X., Li, P., He, C., He, P., Cheng, S., Song, Z. (2023) Danggui Shaoyao San ameliorates the lipid metabolism via the PPAR signaling pathway in a Danio rerio (zebrafish) model of hyperlipidemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 168:115736115736
- Verwilligen, R.A.F., Mulder, L., Rodenburg, F.J., Van Dijke, A., Hoekstra, M., Bussmann, J., Van Eck, M. (2022) Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Atherosclerosis. 346:18-25
- Gourain, V., Armant, O., Lübke, L., Diotel, N., Rastegar, S., Strähle, U. (2021) Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury. Frontiers in neuroscience. 15:671249
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Singh, M.K., Jayarajan, R., Varshney, S., Upadrasta, S., Singh, A., Yadav, R., Scaria, V., Sengupta, S., Shanmugam, D., Shalimar, ., Sivasubbu, S., Gandotra, S., Sachidanandan, C. (2021) Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(5):158905
- Sulliman, N.C., Ghaddar, B., Gence, L., Patche, J., Rastegar, S., Meilhac, O., Diotel, N. (2021) HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors. Scientific Reports. 11:6439
- Thiel, W., Esposito, E.J., Findley, A.P., Blume, Z.I., Mitchell, D.M. (2021) Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. Biology Open. 11(1):
1 - 10 of 29
Show