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Figure 6

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ZDB-IMAGE-210930-10

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Qi et al., 2021 - Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations

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Figure 6

ACR induced alterations on retinal hyaloid vasculature and downregulation of insra/insrb mRNA expression at 5dpf. A) Representative confocal images of hyaloid vasculature. White scale bar: 20 µm. B,C) Quantification of hyaloid vasculature showed significant increasing numbers of branches in akr1a1a1^+/+ larvae incubated with 10 µm ACR. n = 13–16. White scale bar = 20 µm. D) Insa mRNA expression was unaltered in akr1a1a1^+/+ larvae upon ACR treatment. n = 7 clutches with 30 larvae. E) Whole‐body glucose measurement showed higher glucose level in akr1a1a1^+/+ larvae upon 10 µm ACR treatment at 5dpf. n = 4 clutches with 20 larvae. F,G) Both insra and insrb showed declined mRNA expression level in akr1a1a1^+/+ larvae upon 10 µm ACR treatment. n = 7 clutches with 30 larvae. For statistical analysis Student's t‐test was applied. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. NS, not significant.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Adv Sci (Weinh)