Gene
insra
- ID
- ZDB-GENE-020503-3
- Name
- insulin receptor a
- Symbol
- insra Nomenclature History
- Previous Names
-
- IRa (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable insulin receptor activity and insulin receptor substrate binding activity. Acts upstream of or within with a positive effect on glycolytic process. Acts upstream of or within with a negative effect on gluconeogenesis. Acts upstream of or within chordate embryonic development; developmental growth; and sprouting angiogenesis. Predicted to be located in membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including fertilized egg; immature eye; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); hepatocellular carcinoma; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Donohue syndrome | Alliance | Donohue syndrome | 246200 |
| familial hyperinsulinemic hypoglycemia 5 | Alliance | Hyperinsulinemic hypoglycemia, familial, 5 | 609968 |
| Diabetes mellitus, insulin-resistant, with acanthosis nigricans | 610549 | ||
| Rabson-Mendenhall syndrome | 262190 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Insulin receptor, trans-membrane domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, insulin-like receptor | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BIL6 | InterPro | 1362 | ||||||||||||||||||
| UniProtKB:B7SNG4 | InterPro | 1353 |
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- Genome Browsers
Interactions and Pathways
Plasmids
No data available
- Benchoula, K., Serpell, C.J., Mediani, A., Albogami, A., Misnan, N.M., Ismail, N.H., Parhar, I.S., Ogawa, S., Hwa, W.E. (2024) 1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene. Scientific Reports. 14:38233823
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
- Diogo, P., Martins, G., Simão, M., Marreiros, A., Eufrásio, A.C., Cabrita, E., Gavaia, P.J. (2023) Type I Diabetes in Zebrafish Reduces Sperm Quality and Increases Insulin and Glucose Transporter Transcripts. International Journal of Molecular Sciences. 24(8):
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Qian, X., Klatt, S., Bennewitz, K., Wohlfart, D.P., Lou, B., Meng, Y., Buettner, M., Poschet, G., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Fleming, I., Szendroedi, J., Nawroth, P.P., Kroll, J. (2023) Impaired Detoxification of Trans, Trans-2,4-Decadienal, an Oxidation Product from Omega-6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(4):e2302325
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