Gene

insra

ID
ZDB-GENE-020503-3
Name
insulin receptor a
Symbol
insra Nomenclature History
Previous Names
  • IRa (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable insulin receptor substrate binding activity and insulin-activated receptor activity. Acts upstream of or within with a positive effect on glycolytic process. Acts upstream of or within with a negative effect on gluconeogenesis. Acts upstream of or within chordate embryonic development and developmental growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including fertilized egg; immature eye; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With insra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Donohue syndrome Alliance Leprechaunism 246200
familial hyperinsulinemic hypoglycemia 5 Alliance Hyperinsulinemic hypoglycemia, familial, 5 609968
Diabetes mellitus, insulin-resistant, with acanthosis nigricans 610549
Rabson-Mendenhall syndrome 262190
Associated With insra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Domain IPR000494 Receptor L-domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003961 Fibronectin type III
Domain IPR006211 Furin-like cysteine-rich domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR040969 Insulin receptor, trans-membrane domain
Family IPR016246 Tyrosine-protein kinase, insulin-like receptor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036941 Receptor L-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Furin-like cysteine-rich domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Immunoglobulin-like fold Insulin receptor, trans-membrane domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor L-domain Receptor L-domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, insulin-like receptor Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:F1QNX5 1353
UniProtKB:B8PR94 112
UniProtKB:B7SNG4 1353
UniProtKB:Q8QGM9 133
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations