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ZDB-IMAGE-210103-27

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Wu et al., 2020 - Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling

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FIGURE 5

Validate the microarray data with qPCR for the five genes upregulated by OF (A‐G), and three genes downregulated by OF (H–J) in [HBx,src] and [HBx,src,p53^−/+] transgenic zebrafish. The OF upregulated and downregulated genes from microarray and survival probability in liver cancer patients according to The Cancer Genome Atlas (TCGA) database. A‐G, Genes were upregulated by oligo‐fucoidan correlated to prolong survival rate in HCC patients. H‐J, Genes were downregulated by oligo‐fucoidan, and their expression correlated to poorer survival rate in HCC patients. Statistical significance was calculated by t‐test: *P ≤ .05, **P ≤ .01, ***P ≤ .001.

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