Gene
rorab
- ID
- ZDB-GENE-040426-855
- Name
- RAR-related orphan receptor A, paralog b
- Symbol
- rorab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; brain; immature eye; optic primordium; and visual system. Orthologous to human RORA (RAR related orphan receptor A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu270 (9 images)
- bc051158 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rorab | Thyme et al., 2019 | |
| CRISPR2-rorab | Thyme et al., 2019 | |
| CRISPR3-rorab | Thyme et al., 2019 | |
| CRISPR4-rorab | Thyme et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with or without epilepsy or cerebellar ataxia | 618060 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR044101 | Retinoid-related orphan receptors, DNA-binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003079 | Nuclear receptor ROR |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor ROR | Retinoid-related orphan receptors, DNA-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QBZ9 | InterPro | 516 | |||||||
| UniProtKB:F1QJF4 | InterPro | 474 | |||||||
| UniProtKB:A0A8M6YZZ4 | InterPro | 545 | |||||||
| UniProtKB:A0A1D5NSP3 | InterPro | 526 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-50E6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-182O15 | ZFIN Curated Data | |
| Encodes | EST | bc051158 | Bertrand et al., 2007 | |
| Encodes | EST | eu270 | Thisse et al., 2005 | |
| Encodes | EST | fq24g04 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:55954 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174539 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201067 (1) | 4141 nt | ||
| Genomic | GenBank:CR388046 (2) | 211210 nt | ||
| Polypeptide | UniProtKB:A0A8M6YZZ4 (1) | 545 aa |
- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Bolton, C.M., Bekaert, M., Eilertsen, M., Helvik, J.V., Migaud, H. (2021) Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Frontiers in Physiology. 12:761109
- Zheng, X., Zhang, K., Zhao, Y., Fent, K. (2021) Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans. Environment International. 149:106159
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Wu, S.Y., Yang, W.Y., Cheng, C.C., Lin, K.H., Sampurna, B.P., Chan, S.M., Yuh, C.H. (2020) Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. Clinical and translational medicine. 10:e252
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Nakayama, Y., Inomata, C., Yuikawa, T., Tsuda, S., Yamasu, K. (2017) Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis. Developmental Biology. 430(1):237-248
- Silva, N., Louro, B., Trindade, M., Power, D.M., Campinho, M.A. (2017) Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis. Scientific Reports. 7:16657
- Ben-Moshe Livne, Z., Alon, S., Vallone, D., Bayleyen, Y., Tovin, A., Shainer, I., Nisembaum, L.G., Aviram, I., Smadja-Storz, S., Fuentes, M., Falcón, J., Eisenberg, E., Klein, D.C., Burgess, H.A., Foulkes, N.S., Gothilf, Y. (2016) Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. PLoS Genetics. 12:e1006445
- Haggard, D.E., Noyes, P.D., Waters, K.M., Tanguay, R.L. (2016) Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicology and applied pharmacology. 308:32-45
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