Gene

foxo3b

ID
ZDB-GENE-990708-6
Name
forkhead box O3b
Symbol
foxo3b Nomenclature History
Previous Names
  • foxo5
  • fkhr (1)
  • wu:fj65a12 (1)
  • zFkhr (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of defense response to virus; and primitive hemopoiesis. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including immune system; liver; nervous system; pericardial region; and posterior lateral mesoderm. Orthologous to human FOXO3 (forkhead box O3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxo3b Human Ortholog
No data available
Associated With foxo3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Domain IPR032067 FOXO protein, transactivation domain
Domain IPR032068 FOXO protein, KIX-binding domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Fork head domain Fork head domain conserved site 2 FOXO protein, KIX-binding domain FOXO protein, transactivation domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q9PVK6 204
UniProtKB:Q5TYS1 651
UniProtKB:Q9W7F8 651
UniProtKB:B3DGQ4 651
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations